Publications

• 2023
  
  

  •  Ligand-induced protein stabilization and enhanced molecular dynamics sampling techniques   Timo Schäfer, Andreas C. Joerger, John Spencer, Friederike Schmid & Giovanni Settanni

  • Epidrugs as Promising Tools to Eliminate Plasmodium falciparum Artemisinin-Resistant and Quiescent ParasitesThibaud Reyser, Lucie Paloque, Michel Nguyen, Jean-Michel Augereau, Matthew John Fuchter, Marie Lopez, Paola B. Arimondo, John Spencer, Luisa Di Stefano & Françoise Benoit-Vical

  • Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors The COVID Moonshot Consortium

  •  The Crystal Structure of the Hsp90-LA1011 Complex and the Mechanism by Which LA1011 May Improve the Prognosis of Alzheimer’s Disease S. Mark Roe, Zsolt Török, Andrew McGown, Ibolya Horváth, John Spencer, Tamás Pázmány, László Vigh & Chrisostomos Prodromou

  • A change of direction through trans-bis-silylation of alkynes John Spencer

  • The Crystal Structure of the Hsp90-LA1011 Complex and the Mechanism by which LA1011 may Improve the Prognosis of Alzheimer’s Disease Mark Roe, Andrew McGown, Ibolya Horváth, John Spencer, Tamás Pázmány, László Vigh & Chrisostomos Prodromou

  • High-throughput crystallography for rapid fragment growth from crude arrays by low-cost robotics Harold Grosjean, Anthony Aimon, Storm Hassell-Hart, Warren Thompson,Lizbé Koekemoer,James Bennett,Cameron Anderson,Edward A FitzGerald,Tobias Kroje,Anthony Bradle,Oleg Fedoro, Philip C. Biggi,John Spencer,Frank von Delft

  • Flexibility versus rigidity: how conformational constraint, steric hinderance and solvent impact binding between p-electron poor tweezer-type hosts and p-electron rich guests 

    Lydia Panther, Monika Stankunaite, Manvendra Sharma, John Spencer, Barnaby Greenland

  • The Inhibitory Properties of a Novel, Selective LMTK3 Kinase Inhibitor Alessandro Agnarelli, Andrea Lauer Betrán, Athanasios Papakyriakou, Viviana Vella,Mark Samuels, Panagiotis Papanastasopoulos, Christina Giamas, Erika J. Mancini, Justin Stebbing,John Spencer, Chiara Cilibrasi, Angeliki Ditsiou and Georgios Giamas

  • Niclosamide does not modulate airway epithelial function through blocking of the calcium activated chloride channel, TMEM16A Henry Danahay, Sarah Lilley, Kathryn Adley, Holly Charlton, Roy Fox and Martin Gosling

  • Chirality: a Key Parameter in Chemical ProbesAndrew McGown,  Jordan Nafie,  Mohammed Otayfah,  Storm Hassell-Hart,  Graham J. Tizzard,  Simon Coles, Rebecca Banks, Graham Marsh,  HANNAH Jane MAPLE, George E. Kostakis, Ilaria Proietti Silvestri, Paul Colbon and John Spencer  

• 2022
  • Medeiros, Gisele A, Rodrigues, Carime V, Spencer, John and Neto, Brenno AD (2022) Carbon dots (C-dots): fluorescence processes and intracellular bioimaging. In: Henini, Mohamed and Rodrigues, Marcelo Oliveira (eds.) Quantum Materials, Devices, and Applications. Elsevier. ISBN 9780128205662 Item availability may be restricted.

  • Crystal structure and metal binding properties of the periplasmic iron component EfeM from Pseudomonas syringae EfeUOB/M iron-transport system Crystal structure and metal binding properties of the periplasmic iron component EfeM from Pseudomonas syringae EfeUOB/M iron-transport system - PubMed (nih.gov) Mohan B Rajasekaran 1 2, Rohanah Hussain 3, Giuliano Siligardi 3, Simon C Andrews 1, Kimberly A Watson 4

  • Panther, Lydia A, Guest, Daniel P, McGown, Andrew, Emerit, Hugo, Tareque, Raysa K, Jose, Arathy, Dadswell, Chris M, Coles, SimonJ, Tizzard, Graham J, González-Méndez, Ramon, Goodall, Charles AI, Bagley, Mark C, Spencer, John and Greenland, Barnaby W (2022) Solvent-free synthesis of core-functionalised naphthalene diimides by using a vibratory ball mill: Suzuki, Sonogashira and Buchwald–Hartwig reactions. Chemistry - A European Journal, 28 (49). e202201444 1-12. ISSN 0947-6539
  • Greenland, Barnaby, Lam, Wing T, Babra, Tahkur S, Smith, Julian H D, Bagley, Mark C, Spencer, John and Wright, Edward (2022) Synthesis and evaluation of a silver nanoparticle/polyurethane composite that exhibits antiviral activity against SARS-CoV-2. Polymers, 14 (19). a4172 1-11. ISSN 2073-4360
  • Hassell-Hart, Storm, Speranzini, Elisa, Srikwanjai, Sirihathai, Hossack, Euan, Roe, S Mark, Fearon, Daren, Akinbosede, Daniel, Hare, Stephen and Spencer, John (2022) Synthesis of a thiazole library via an iridium-catalyzed sulfur ylide insertion reaction. Organic Letters. ISSN 1523-7060
  • McGown, Andrew, Edmonds, Anthony K, Guest, Daniel, Holmes, Verity L, Dadswell, Chris, González-Méndez, Ramón, Goodall, Charles AI, Bagley, Mark C, Greenland, Barnaby W and Spencer, John (2022) A convenient, rapid, conventional heating route to MIDA boronates. Molecules, 27 (16). pp. 1-11. ISSN 1420-3049
  • Spencer, John (2022) [Review] Schnider, Patrick (2021) The medicinal chemist's guide to solving ADMET challenges. ChemMedChem. a202200249. ISSN 1860-7179 Item availability may be restricted.
  • Edmonds, Anthony K, Oakes, Catherine S, Hassell-Hart, Storm, Bruyère, Didier, Tizzard, Graham J, Coles, Simon J, Felix, Robert, Maple, Hannah J, Marsh, Graham P and Spencer, John (2022) Scale-up and optimization of the synthesis of dual CBP/BRD4 inhibitor ISOX-DUAL. Organic and Biomolecular Chemistry. ISSN 1477-0520
  • Jose, Arathy, Guest, Daniel, LeGay, Remi, Tizzard, Graham J, Coles, Simon J, Derveni, Mariliza, Wright, Edward, Marrison, Lester, Lee, Alpha A, Morris, Aaron, Robinson, Matt, Delft, Frank, Fearon, Daren, Koekemoer, Lizbé, Matviuk, Tetiana, Aimon, Anthony, Schofield, Christopher J, Malla, Tika R, London, Nir, Greenland, Barnaby W, Bagley, Mark C, Spencer, John and The Covid Moonshot Consortium, (2022) Expanding the repertoire of low‐molecular‐weight pentafluorosulfanyl‐substituted scaffolds. ChemMedChem. a202100641 1-12. ISSN 1860-7179
  • THE UNIVERSITY OF SUSSEX [GB/GB]; Sussex House Falmer Brighton Sussex BN1 9RH (GB) (2022) Small molecule inhibitors of Lemur tyrosine kinase 3 (LTK). .
  • Neto, Brenno A D, Correra, Jose R and Spencer, John (2022) Fluorescent benzothiadiazole derivatives as fluorescence imaging dyes: a decade of a new generation probes. Chemistry: A European Journal, 28 (4). e202103262. ISSN 0947-6539 Item availability may be restricted.
  • Gil-Moles, Maria, Türck, Sebastian, Basu, Uttara, Pettenuzzo, Andrea, Bhattacharya, Saurav, Rajan, Ananthu, Ma, Xiang, Büssing, Rolf, Wölker, Jessica, Burmeister, Hilke, Kusi-Nimarko, Josephine, Hassell-Hart, Storm, McGown, Andrew, Guest, Daniel, Spencer, John and others, (2021) Metallodrug profiling against SARS-CoV-2 target proteins identifies highly potent inhibitors of the S/ACE2 interaction and the papain-like protease PL^pro. Chemistry - A European Journal, 27 (71). pp. 17928-17940. ISSN 0947-6539
  • Lydia A. Panther,Dr. Daniel P. Guest,Dr. Andrew McGown,Hugo Emerit,Dr. Raysa Khan Tareque,Dr. Arathy Jose,Mr. Chris M. Dadswell,Dr. Simon J. Coles,Dr. Graham J. Tizzard,Dr. Ramón González-Méndez,Dr. Charles A. I. Goodall,Prof. Mark C. Bagley,Prof. John Spencer,Dr. Barnaby W. Greenland (2022) Solvent-Free Synthesis of Core-Functionalised Naphthalene Diimides by Using a Vibratory Ball Mill: Suzuki, Sonogashira and Buchwald–Hartwig Reactions
  • Chadet, S., Allard, J., Brisson, L. et al. (2022) P2x4 receptor promotes mammary cancer progression by sustaining autophagy and associated mesenchymal transition
  • Murrell-Lagnado RD, Kawate T. Methods for Studying Cholesterol-Dependent Regulation of P2X7 Receptors. Methods Mol Biol. 2022;2510:253-264. doi: 10.1007/978-1-0716-2384-8_13. PMID: 35776329.
  • Lee, D.F., Thompson, C.L., Baynes, R.E. et al.Development and evaluation of a bovine lung-on-chip (bLOC) to study bovine respiratory diseases. In vitro models (2022). https://doi.org/10.1007/s44164-022-00030-z
  • Szibor M, Schenkl C, Barsottini MRO, Young L, Moore AL. Targeting the alternative oxidase (AOX) for human health and food security, a pharmaceutical and agrochemical target or a rescue mechanism? Biochem J. 2022 Jun 30;479(12):1337-1359. doi: 10.1042/BCJ20180192. PMID: 35748702; PMCID: PMC9246349.
• 2021
  • Devonport, Jack, Sully, Lauren, Boudalis, Athanassios K, Hassell-Hart, Storm, Leech, Matthew C, Lam, Kevin, Abdul-Sada, Alaa, Tizzard, Graham J, Coles, Simon J, Spencer, John, Vargas, Alfredo and Kostakis, George E (2021) Room temperature Cu(II) radical-triggered alkyne C-H activation. JACS Au, 1 (11). pp. 1937-1948. ISSN 2691-3704
  • Devonport, Jack, Bodnár, Nikolett, McGown, Andrew, Maina, Mahmoud Bukar, Serpell, Louise C, Kállay, Csilla, Spencer, John and Kostakis, George E (2021) Salpyran: a Cu(II) selective chelator with therapeutic potential. Inorganic Chemistry, 60 (20). pp. 15310-15320. ISSN 0020-1669 Item availability may be restricted.
  • Devonport, Jack, Spencer, John and Kostakis, George E (2021) Breaking the symmetry: C1-salans with (N-H) backbones. Dalton Transactions. ISSN 1477-9226
  • Rubbiani, Riccardo, Weil, Tobias, Tocci, Noemi, Mastrobuoni, Luciano, Jeger, Severin, Moretto, Marco, Ng, James, Lin, Yan, Hess, Jeannine, Ferrari, Stefano, Kaech, Andres, Young, Luke, Spencer, John, Moore, Anthony L and others, (2021) In vivo active organometallic-containing antimycotic agents. RSC Chemical Biology, 2 (4). pp. 1263-1273. ISSN 2633-0679
  • Watson, Adam T, Hassell-Hart, Storm, Spencer, John and Carr, Antony M (2021) Rice (Oryza sativa) TIR1 and 5′adamantyl-IAA significantly improve the auxin-inducible degron system in Schizosaccharomyces pombe. Genes, 12 (6). a882 1-23. ISSN 2073-4425
  • Ansell, Melvyn B, Kostakis, George E, Navarro, Oscar and Spencer, John (2021) Synthesis of trans-mono(silyl)palladium(II) bromide complexes. Molecules, 26 (9). a2460 1-6. ISSN 1420-3049
  • Jose, Arathy, Tareque, Raysa Khan, Mortensen, Martin, Legay, Remi, Coles, Simon J, Tizzard, Graham J, Greenland, Barnaby W, Smart, Trevor G, Bagley, Mark C and Spencer, John (2021) Synthesis and biological evaluation of benzodiazepines containing a pentafluorosulfanyl group. Tetrahedron, 85. a132020 1-6. ISSN 0040-4020
  • Luparello, Claudio, Cruciata, Ilenia, Joerger, Andreas C, Ocasio, Cory A, Jones, Rhiannon, Tareque, Raysa Khan, Bagley, Mark C, Spencer, John, Walker, Martin, Austin, Carol, Ferrara, Tiziana, D′Oca, Pietro, Bellina, Rossella, Branni, Rossella and Caradonna, Fabio (2021) Genotoxicity and epigenotoxicity of carbazole-derived molecules on mcf-7 breast cancer cells. International Journal of Molecular Sciences, 22 (7). a3410 1-14. ISSN 1661-6596
  • Hassell-Hart, Storm, Picaud, Sarah, Lengacher, Raphael, Csucker, Joshua, Millet, Regis, Gasser, Gilles, Alberto, Roger, Maple, Hannah, Felix, Robert, Leśnikowski, Zbigniew J, Stewart, Helen J S, Chevassut, Timothy J, Morley, Simon, Filippakopoulos, Panagis and Spencer, John (2021) Probing BRD inhibition substituent effects in bulky analogues of (+)-JQ1. Helvetica Chimica Acta, 104 (3). a2000214 1-7. ISSN 0018-019X
  • Kaya, Ecem, Smith, David A, Smith, Claire, Morris, Lauren, Bremova-Ertl, Tatiana, Cortina-Borja, Mario, Fineran, Paul, Morten, Karl J, Poulton, Joanna, Boland, Barry, Spencer, John, Strupp, Michael and Platt, Frances M (2020) Acetyl-leucine slows disease progression in lysosomal storage disorders. Brain Communications, 3 (1). pp. 1-52. ISSN 2632-1297 Item availability may be restricted.
  • Gil-Moles, Maria, Türck, Sebastian, Basu, Uttara, Pettenuzzo, Andrea, Bhattacharya, Saurav, Rajan, Ananthu, Ma, Xiang, Büssing, Rolf, Wölker, Jessica, Burmeister, Hilke, Kusi-Nimarko, Josephine, Hassell-Hart, Storm, McGown, Andrew, Guest, Daniel, Spencer, John and others, (2021) Metallodrug profiling against SARS-CoV-2 target proteins identifies highly potent inhibitors of the S/ACE2 interaction and the papain-like protease PL^pro. Chemistry - A European Journal, 27 (71). pp. 17928-17940. ISSN 0947-6539
  • Tan, Sin-Lih, Barri, Muruj, Atakpa-Adaji, Peace, Taylor, Colin W, Smith, Ewan St. John and Murrell-Lagnado, Ruth D (2021) P2x4 receptors mediate Ca²⁺ release from lysosomes in response to stimulation of P2X7 and H<inf>1</inf> histamine receptors. International Journal of Molecular Sciences, 22 (19). a10492 1-15. ISSN 1661-6596
  • Chen, Xiangrong, Ali, Yusuf I, Fisher, Charlotte E L, Arribas-Bosacoma, Raquel, Rajasekaran, Mohan B, Williams, Gareth, Walker, Sarah, Booth, Jessica R, Hudson, Jessica J R, Roe, S Mark, Pearl, Laurence H, Ward, Simon E, Pearl, Frances M G and Oliver, Antony W (2021) Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein. eLife, 10. a65339 1-32. ISSN 2050-084X
  • Godfrey, Anja, Osborn, Kay and Sinclair, Alison J (2021) Interaction sites of the Epstein-Barr virus Zta transcription factor with the host genome in epithelial cells. Access Microbiol, 3 (11). pp. 1-7. ISSN 2516-8290
  • Copsey, Alice C, Barsottini, Mario R O, May, Benjamin, Xu, Fei, Albury, Mary S, Young, Luke and Moore, Anthony L (2021) Kinetic characterisation and inhibitor sensitivity of Candida albicans and Candida auris recombinant AOX expressed in a self-assembled proteoliposome system. Scientific Reports, 11. a14748 1-10. ISSN 2045-2322
  • Xu, Fei, Copsey, Alice C, Young, Luke, Barsottini, Mario R O, Albury, Mary S and Moore, Anthony L (2021) Comparison of the kinetic parameters of alternative oxidases from Trypanosoma brucei and Arabidopsis thaliana-a tale of two cavities. Frontiers in Plant Science, 12. a744218 1-14. ISSN 1664-462X
  • Darren Le Grand, Martin Gosling, Urs Baettig, Parmjit Bahra, Kamlesh Bala, Cara Brocklehurst, Emma Budd, Rebecca Butler, Atwood K. Cheung, Hedaythul Choudhury, Stephen P. Collingwood, Brian Cox, Henry Danahay, Lee Edwards, Brian Everatt, Ulrike Glaenzel, Anne-Lise Glotin, Paul Groot-Kormelink, Edward Hall, Julia Hatto, Catherine Howsham, Glyn Hughes, Anna King, Julia Koehler, Swarupa Kulkarni, Megan Lightfoot, Ian Nicholls, Christopher Page, Giles Pergl-Wilson, Mariana Oana Popa, Richard Robinson, David Rowlands, Tom Sharp, Matthew Spendiff, Emily Stanley, Oliver Steward, Roger J. Taylor, Pamela Tranter, Trixie Wagner, Hazel Watson, Gareth Williams, Penny Wright, Alice Young, and David A. Sandham (2021) Discovery of Icenticaftor (QBW251), a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator with Clinical Efficacy in Cystic Fibrosis and Chronic Obstructive Pulmonary Disease Journal of Medicinal Chemistry64 (11), 7241-7260 DOI: 10.1021/acs.jmedchem.1c00343
  • Gosling, Martin; Lilley, Sarah; Binzer, Thomas; Bell, Damien (2021) Automated Patch Clamp in Cystic Fibrosis Drug Discovery
  • Adcock, Claire; Axford, Jake; Hou, Ying; Kim, Hyungchul; Shen, Yiping; Smith, Nichola; Solovay, Catherine Fooks; Sung, Moo Je; Lightfoot, Megan; Mazzacani, Alessandro; Stanley, Emily; Whitehead, Lewis (2021) Substituted 1,3-Phenyl Heteroaryl Derivatives And Their Use In The Treatment Of Disease
  • Lee DF, Lethem MI, Lansley AB. A comparison of three mucus-secreting airway cell lines (Calu-3, SPOC1 and UNCN3T) for use as biopharmaceutical models of the nose and lung. Eur J Pharm Biopharm. 2021 Oct;167:159-174. doi: 10.1016/j.ejpb.2021.07.016. Epub 2021 Jul 29. PMID: 34332033; PMCID: PMC8422164.
  • Sotaro Yamasaki, Mitsuo Shoji, Megumi Kayanuma, Vladimir Sladek, Daniel Ken Inaoka, Yuichi Matsuo, Tomoo Shiba, Luke Young, Anthony L. Moore, Kiyoshi Kita, Yasuteru Shigeta, Weak O2 binding and strong H2O2 binding at the non-heme diiron center of trypanosome alternative oxidase, Biochimica et Biophysica Acta (BBA) - Bioenergetics, Volume 1862, Issue 4, 2021, 148356, ISSN 0005-2728, https://doi.org/10.1016/j.bbabio.2020.148356.
  • Rosell-Hidalgo, A., Young, L., Moore, A.L. et al.QSAR and molecular docking for the search of AOX inhibitors: a rational drug discovery approach. J Comput Aided Mol Des 35, 245–260 (2021). https://doi.org/10.1007/s10822-020-00360-8
  • Darren Le Grand, Martin Gosling, Urs Baettig, Parmjit Bahra, Kamlesh Bala, Cara Brocklehurst, Emma Budd, Rebecca Butler, Atwood K. Cheung, Hedaythul Choudhury, Stephen P. Collingwood, Brian Cox, Henry Danahay, Lee Edwards, Brian Everatt, Ulrike Glaenzel, Anne-Lise Glotin, Paul Groot-Kormelink, Edward Hall, Julia Hatto, Catherine Howsham, Glyn Hughes, Anna King, Julia Koehler, Swarupa Kulkarni, Megan Lightfoot, Ian Nicholls, Christopher Page, Giles Pergl-Wilson, Mariana Oana Popa, Richard Robinson, David Rowlands, Tom Sharp, Matthew Spendiff, Emily Stanley, Oliver Steward, Roger J. Taylor, Pamela Tranter, Trixie Wagner, Hazel Watson, Gareth Williams, Penny Wright, Alice Young, and David A. Sandham Discovery of Icenticaftor (QBW251), a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator with Clinical Efficacy in Cystic Fibrosis and Chronic Obstructive Pulmonary Disease 2021 64 (11), 7241-7260 DOI: 10.1021/acs.jmedchem.1c00343
  • Kazani S, Rowlands DJ, Bottoli I, Milojevic J, Alcantara J, Jones I, Kulmatycki K, Machineni S, Mostovy L, Nicholls I, Nick JA, Rowe SM, Simmonds NJ, Vegesna R, Verheijen J, Danahay H, Gosling M, Ayalavajjala PS, Salman M, Strieter R. Safety and efficacy of the cystic fibrosis transmembrane conductance regulator potentiator icenticaftor (QBW251). J Cyst Fibros. 2021 Mar;20(2):250-256. doi: 10.1016/j.jcf.2020.11.002. Epub 2020 Dec 6. PMID: 33293212; PMCID: PMC8935475.
• 2020
  • Tareque, Raysa Kahn, Hassell-Hart, Storm, Krojer, Tobias, Bradley, Anthony, Velupillai, Srikannathasan, Talon, Romain, Fairhead, Michael, Day, Iain J, Bala, Kamlesh, Felix, Robert, Kemmitt, Paul, Brennan, Paul, von Delft, Frank, Díaz Sáez, Laura, Spencer, John and Huber, Kilian (2020) Deliberately losing control of C-H activation processes in the design of small molecule fragment arrays targeting peroxisomal metabolism. ChemMedChem. ISSN 1860-7179
  • Ditsiou, Angeliki, Cilibrasi, Chiara, Simigdala, Nikiana, Harris, Leanne, Vella, Viviana, Gagliano, Teresa, Iachini, Maria Chiara, Simon, Thomas, Zhou, Lihong, Hassell-Hart, Storm, Pearl, Laurence H, Roe, S Mark, Spencer, John, Prodromou, Chrisostomos, Giamas, Georgios and others, (2020) The structure-function relationship of oncogenic LMTK3. Science Advances, 6 (46). pp. 1-19. ISSN 2375-2548
  • Amer Hamzah, Harina, Rixson, Daniel, Paul-Taylor, Joseph, Doan, Huan V, Dadswell, Christopher, Roffe, Gavin W, Sridhar, Arun, Hobday, Claire L, Wedd, Charlie, Düren, Tina, Hughes, William O H, Spencer, John and Burrows, Andrew D (2020) Inclusion and release of ant alarm pheromones from metal–organic frameworks. Dalton Transactions. ISSN 1477-9226
  • Bauer, Matthias R, Krämer, Andreas, Settanni, Giovanni, Jones, Rhiannon N, Ni, Xiaomin, Tareque, Raysa Khan, Fersht, Alan R, Spencer, John and Joerger, Andreas C (2020) Targeting cavity-creating p53 cancer mutations with small-molecule stabilizers: the Y220X paradigm. ACS Chemical Biology. ISSN 1554-8929
  • Hassell-Hart, Storm, Runcie, Andrew, Krojer, Tobias, Doyle, Jordan, Lineham, Ella, Ocasio, Cory A, Neto, Brenno A D, Fedorov, Oleg, Marsh, Graham, Maple, Hannah, Felix, Robert, Banks, Rebecca, Ciulli, Alessio, Picaud, Sarah, Filippakopoulos, Panagis, von Delft, Frank, Brennan, Paul, Stewart, Helen J S, Chevassut, Timothy J, Walker, Martin, Austin, Carol, Morley, Simon and Spencer, John (2019) Synthesis and biological investigation of (+)-JD1, an organometallic BET bromodomain inhibitor. Organometallics. ISSN 0276-7333
  • Sansook, Supojjanee, Hassell-Hart, Storm, Ocasio, Cory and Spencer, John (2019) Ferrocenes in medicinal chemistry; a personal perspective. Journal of Organometallic Chemistry, 905. pp. 1-17. ISSN 0022-328X
  • Danahay, H, Fox, R, Lilley, S, Charlton, H, Adley, K, Christie, L, Ansari, E, Ehre, C, Flen, A, Tuvim, M J, Dickey, B F, Williams, C, Beaudoin, S, Collingwood, S P and Gosling, M (2020) Potentiating TMEM16A does not stimulate airway mucus secretion or bronchial and pulmonary arterial smooth muscle contraction. FASEB BioAdvances, 2. pp. 464-477. ISSN 2573-9832
  • Danahay, Hannah L, Lilley, Sarah, Fox, Roy, Charlton, Holly, Sabater, Juan, Button, Brian, McCarthy, Clive, Collingwood, Stephen P and Gosling, Martin (2020) TMEM16A potentiation: a novel therapeutic approach for the treatment of cystic fibrosis. American Journal of Respiratory and Critical Care Medicine, 201 (8). pp. 946-954. ISSN 1073-449X
  • Zhou, Yaqi, Heesom, Kate, Osborn, Kay, Almohammed, Rajaei, Sweet, Steve M and Sinclair, Alison J (2019) Identifying the cellular interactome of Epstein-Barr virus lytic regulator Zta reveals cellular targets contributing to viral replication. Journal of Virology. ISSN 0022-538X
  • Young, Luke, Rosell-Hidalgo, Alicia, Inaoka, Daniel Ken, Xu, Fei, Albury, Mary, May, Benjamin, Kita, Kiyoshi and Moore, Anthony L (2020) Kinetic and structural characterisation of the ubiquinol-binding site and oxygen reduction by the trypanosomal alternative oxidase. BBA - Bioenergetics, 1861 (10). a148247. ISSN 0005-2728
  • Danahay, H, Fox, R, Lilley, S, Charlton, H, Adley, K, Christie, L, Ansari, E, Ehre, C, Flen, A, Tuvim, M J, Dickey, B F, Williams, C, Beaudoin, S, Collingwood, S P and Gosling, M (2020) Potentiating TMEM16A does not stimulate airway mucus secretion or bronchial and pulmonary arterial smooth muscle contraction. FASEB BioAdvances, 2. pp. 464-477. ISSN 2573-9832
  • Danahay, Hannah L, Lilley, Sarah, Fox, Roy, Charlton, Holly, Sabater, Juan, Button, Brian, McCarthy, Clive, Collingwood, Stephen P and Gosling, Martin (2020) TMEM16A potentiation: a novel therapeutic approach for the treatment of cystic fibrosis. American Journal of Respiratory and Critical Care Medicine, 201 (8). pp. 946-954. ISSN 1073-449X
  • BASUMATARY, D., SHANKAR, M.K., BYRAPPA, K. et al.Polymorph of trans-dichlorotetrakis(pyridine-N)ruthenium(II) influenced by a dihydrazone: crystal structure, spectral, Hirshfeld surfaces, antimicrobial, toxicity and in silico docking studies. J Chem Sci 132, 133 (2020). https://doi.org/10.1007/s12039-020-01829-7
  • Direct oxidation of alcohols catalysed by heterometallic complex [CuNi(bz)<inf>3</inf>(bpy)<inf>2</inf>]ClO<inf>4</inf> to aldehydes and ketones mediated by hydrogen peroxide as a terminal oxidant
  • Henry Danahay, Roy Fox, Sarah Lilley, Holly Charlton, Kathryn Adley, Lee Christie, Ejaz Ansari, Camille Ehre, Alexis Flen, Michael J. Tuvim, Burton F. Dickey, Colin Williams, Sarah Beaudoin, Stephen P Collingwood, Martin Gosling Potentiating TMEM16A channel function has no effect on airway goblet cells or bronchial and pulmonary vascular smooth muscle function https://doi.org/10.1101/2020.04.17.046177
  • Adcock Claire (US), Bonazzi Simone (US), Cernijenko Artiom (US), Lam Philip (US), Linkens Kathryn Taylor (US), Malik Hasnain Ahmed (US), Thomsen Noel Marie-France (US), Visser Michael Scott (US) 3-(5-hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
  • Lee, D.F., Stewart, G.R. & Chambers, M.A. Modelling early events in Mycobacterium bovis infection using a co-culture model of the bovine alveolus. Sci Rep 10, 18495 (2020). https://doi.org/10.1038/s41598-020-75113-6
  • Barsottini, M.R.O., Copsey, A., Young, L. et al.Biochemical characterization and inhibition of the alternative oxidase enzyme from the fungal phytopathogen Moniliophthora perniciosa. Commun Biol 3, 263 (2020). https://doi.org/10.1038/s42003-020-0981-6
  • Rubbiani R, Weil T, Tocci N, Mastrobuoni L, Jeger S, Moretto M, et al. From Design to in Vivo Active Organometallic-Containing Antimycotic Agents. ChemRxiv. Cambridge: Cambridge Open Engage; 2020;  This content is a preprint and has not been peer-reviewed.
  • Danahay HL, Morris DG, Gosling M. Reply to Olschewski et al.: TMEM16A Potentiation: Possible Drawbacks. Am J Respir Crit Care Med. 2020 Sep 15;202(6):905-906. doi: 10.1164/rccm.202004-1214LE. PMID: 32464067; PMCID: PMC7491402.
  • Danahay H, Gosling M. TMEM16A: An Alternative Approach to Restoring Airway Anion Secretion in Cystic Fibrosis? Int J Mol Sci. 2020 Mar 30;21(7):2386. doi: 10.3390/ijms21072386. PMID: 32235608; PMCID: PMC7177896.
  • Rowe SM, Jones I, Dransfield MT, Haque N, Gleason S, Hayes KA, Kulmatycki K, Yates DP, Danahay H, Gosling M, Rowlands DJ, Grant SS. Efficacy and Safety of the CFTR Potentiator Icenticaftor (QBW251) in COPD: Results from a Phase 2 Randomized Trial. Int J Chron Obstruct Pulmon Dis. 2020 Oct 5;15:2399-2409. doi: 10.2147/COPD.S257474. PMID: 33116455; PMCID: PMC7547289.
• 2019
  • Spencer, John, Gascon, Jose Miguel, Oliveri, Valentina, McGown, Andrew, Kaya, Ecem, Chen, yu-lin, Austin, Carol, Walker, Martin, Platt, Frances and Vecchio, Graziella (2019) Synthesis and study of novel multifunctional cyclodextrin‐deferasirox hybrids. ChemMedChem. ISSN 1860-7179
  • Commandeur, Daniel, Brown, Grant, Mcnulty, Peter, Dadswell, Christopher, Spencer, John and Chen, Qiao (2019) Yttrium doped ZnO nanorod arrays for increased charge mobility and carrier density for enhanced solar water splitting. The Journal of Physical Chemistry C. ISSN 1932-7455
  • Khan, Raysa and Spencer, John (2019) Palladacyclic complexes as efficient catalysts for CdH bond functionalization reactions. In: Kapdi, Anant and Maiti, Debabrata (eds.) Palladacycles. Elsevier, pp. 249-262. ISBN 9780128155059 Item availability may be restricted.
  • Sampani, Stavroula I, McGown, Andrew, Vargas, Alfredo, Abdul-Sada, Alaa, Tizzard, Graham J, Coles, Simon J, Spencer, John and Kostakis, George E (2019) Solvent-free synthesis and key intermediate isolation in Ni2Dy2 catalyst development in the domino ring-opening electrocyclization reaction of furfural and amines. The Journal of Organic Chemistry. ISSN 0022-3263
  • Baguña Torres, Julia, Yu, Zilin, Bordoloi, Jayanta, Sunassee, Kavitha, Smith, David, Smith, Claire, Chen, Oscar, Purchase, Rupert, Tuschl, Karin, Spencer, John, Platt, Frances and Blower, Philip J (2019) Imaging of changes in copper trafficking and redistribution in a mouse model of Niemann-Pick C disease using positron emission tomography. BioMetals, 32 (2). pp. 293-306. ISSN 0966-0844
  • Commandeur, Daniel, Brown, Grant, Hills, Edward, Spencer, John and Chen, Qiao (2019) Defect-rich ZnO nanorod arrays for efficient solar water splitting. ACS Applied Nano Materials, 2 (3). pp. 1570-1578. ISSN 2574-0970
  • Luparello, Claudio, Asaro, Dalia Maria Lucia, Cruciata, Ilenia, Hassell-Hart, Storm, Sansook, Supojjanee, Spencer, John and Caradonna, Fabio (2019) Cytotoxic activity of the histone deacetylase 3-Selective inhibitor Pojamide on MDA-MB-231 triple-negative breast cancer cells. International Journal of Molecular Sciences, 20 (4). 804 1-14. ISSN 1661-6596
  • Bauer, Matthias, Jones, Alice Rhiannon, Khan, Raysa, Springett, Bradley, Dingler, Felix, Verduci, Lorena, Patel, Ketan, Fersht, Alan, Joerger, Andreas and Spencer, John (2019) A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C. Future Medicinal Chemistry, 11 (19). pp. 2491-2504. ISSN 1756-8919 Item availability may be restricted.
  • Khan, Raysa and Spencer, John (2019) Palladacyclic complexes as efficient catalysts for CdH bond functionalization reactions. In: Kapdi, Anant and Maiti, Debabrata (eds.) Palladacycles. Elsevier, pp. 249-262. ISBN 9780128155059 Item availability may be restricted.
  • Neto, Brenno D, Carvalho, Pedro H P R, Correa, Jose R, Paiva, Karen, Baril, Michele, Machado, Daniel, Scholten, Jackson D, de Souza, Paulo Eduardo Narcizo, Veiga-Souza, Fabiane and Spencer, John (2019) When the strategies for cellular selectivity fail. Challenges and surprises in the design and application of fluorescent benzothiadiazole derivatives for mitochondrial staining. Organic Chemistry Frontiers. ISSN 2052-4129
  • Lineham, Ella, Tizzard, Graham J, Coles, Simon J, Spencer, John and Morley, Simon (2019) Synergistic effects of inhibiting the MNK-eIF4E and PI3K/AKT/mTOR pathways on cell migration in MDA-MB-231 cells. Oncotarget, 9 (18). pp. 14148-14159. ISSN 1949-2553
  • Murrell-Lagnado, Ruth D and Frick, Manfred (2019) P2X4 and lysosome fusion. Current Opinion in Pharmacology, 47. pp. 126-132. ISSN 1471-4892 Item not available from this repository
  • O’Reilly, Molly, Young, Luke, Kirkwood, Nerissa K, Richardson, Guy P, Kros, Corné J and Moore, Anthony L (2019) Gentamicin affects the bioenergetics of isolated mitochondria and collapses the mitochondrial membrane potential in cochlear sensory hair cells. Frontiers in Cellular Neuroscience, 13 (a416). pp. 1-12. ISSN 1662-5102
  • Shiba, Tomoo, Inaoka, Daniel Ken, Takahashia, Gen, Tsuge, Chiaka, Kido, Yasutoshi, Young, Luke, Ueda, Satoshi, Baloguna, Emmanuel Oluwadare, Narah, Takeshi, Honma, Teruki, Tanaka, Akiko, Inoue, Masayuki, Saimoto, Hiroyuki, Harada, Shigeharu, Moore, Anthony L and Kita, Kiyoshi (2019) Insights into the ubiquinol/dioxygen binding and proton relay pathways of the alternative oxidase. BBA - Bioenergetics, 1860 (5). pp. 375-382. ISSN 0005-2728 Item availability may be restricted.
  • Dr. Jose Miguel Gascon, Dr. Valentina Oliveri, Dr. Andrew McGown, Ecem Kaya, Dr. Yu-Lin Chen, Dr. Carol Austin, Dr. Martin Walker, Prof. Frances M. Platt, Prof. Graziella Vecchio, Prof. John SpencerFront Cover: Synthesis and Study of Multifunctional Cyclodextrin–Deferasirox Hybrids (ChemMedChem 16/2019) https://doi.org/10.1002/cmdc.201900334
  • Paul Beswick, Ben Wahab, Mark A. Honey, Michael Paradowski, Ke Jiang, Martin Lochner, Ruth D. Murrell-Lagnado, Andrew J. Thompson, A challenge finding P2X1 and P2X4 ligands, Neuropharmacology, Volume 157, 2019, 107674, ISSN 0028-3908, https://doi.org/10.1016/j.neuropharm.2019.107674.
  • Ibanphylla Syiemlieh, Mrityunjaya Asthana, Sunshine D. Kurbah, Ram A. Lal, Synthesis, crystal structure and reactivity of homobimetallic vanadium(V) complexes derived from oxaloyldihydrazone ligands, Polyhedron, Volume 170, 2019, Pages 202-216, ISSN 0277-5387, https://doi.org/10.1016/j.poly.2019.05.047.
  • Ibanphylla Syiemlieh,Mrityunjaya Asthana,Ram A. Lal Reactivity and Catalytic Activity of Homobimetallic Vanadium(V) Complex Derived from Bis(5-chlorosalicylaldehyde)oxaloyldihydrazone Ligand https://doi.org/10.1002/aoc.4984
  • Lee DF, Chambers MA. Isolation of Alveolar Type II Cells from Adult Bovine Lung. Curr Protoc Toxicol. 2019 Jun;80(1):e71. doi: 10.1002/cptx.71. Epub 2019 Mar 15. PMID: 30875462.
  • Lee D, Chambers M. A co-culture model of the bovine alveolus. F1000Res. 2019 Apr 1;8:357. doi: 10.12688/f1000research.18696.2. PMID: 31448101; PMCID: PMC6685456.
  • Lee D, Chambers M. A bilayer tissue culture model of the bovine alveolus. F1000Res; 2019. DOI: 10.12688/f1000research.18696.1.
• 2018
  • Ocasio, Cory A., Warkentin, Alexander A, McIntyre, Patrick J, Barkovich, Krister J, Vesely, Clare, Spencer, John, Shokat, Kevan M and Bayliss, Richard (2018) Type II kinase inhibitors targeting Cys-gatekeeper kinases display orthogonality with wild type and Ala/Gly-gatekeeper kinases. ACS Chemical Biology, 13 (10). pp. 2956-2965. ISSN 1554-8929
  • Sansook, Supojjanee, Lineham, Ella, Hassell-Hart, Storm, Tizzard, Graham J, Coles, Simon J, Spencer, John and Morley, Simon J (2018) Probing the anticancer action of novel ferrocene analogues of MNK inhibitors. Molecules, 23 (2126). pp. 1-13. ISSN 1420-3049
  • Velupillai, Srikannathasan, Sáez, Laura Díaz, Krojer, Tobias, Bennett, James, Ruda, Gian Filippo, Szommer, Tamas, Straub, Verena, Nunez Alonso, Graciela, Siejka, Paulina, Bradley, Anthony, Talon, Romain, Fairhead, Michael, Elkins, Jon, London, Nir, Spencer, John, von Delft, Frank, Fedorov, Oleg, Brennan, Paul and Huber, Kilian (2018) Human peroxisomal coenzyme A diphosphatase (NUDT7): a target enabling package (TEP). Zenodo. pp. 1-15.
  • Roffe, Gavin, Boonseng, Sarote, Cox, Hazel and Spencer, John (2018) Unsymmetrical Pincer palladacycles synthesis and reactivity. In: Morales-Morales, David (ed.) Pincer compounds: chemistry and applications. Elsevier, pp. 451-466. ISBN 9780128129319 Item availability may be restricted.
  • Ansell, Melvyn B, Furfari, Samantha K, Cloke, F Geofffrey N, Roe, S Mark, Spencer, John and Navarro, Oscar (2018) Comparison of the reactivity of the low buried-volume carbene complexes (ITMe)2Pd(PhC≡CPh) and (ITMe)2Pd(PhN=NPh). Organometallics, 37 (7). pp. 1214-1218. ISSN 0276-7333 Item availability may be restricted.
  • Spencer, John and Walden, Ben (2018) Special focus: metals in medicine. Future Medicinal Chemistry, 10 (6). pp. 607-609. ISSN 1756-8919
  • Sansook, Supojjanee, Tuo, Wei, Bollier, Mélanie, Barczyk, Amélie, Dezitter, Xavier, Klupsch, Fredérique, Leleu-Chavain, Natascha, Farce, Amaury, Tizzard, Graham J, Coles, Simon J, Spencer, John and Millet, Regis (2018) Synthesis and biological evaluation of ferrocene-based cannabinoid receptor 2 ligands. Future Medicinal Chemistry, 10 (6). pp. 631-638. ISSN 1756-8919
  • Tuo, Wei, Bollier, Mélanie, Leleu-Chavain, Natascha, Lemaire, Lucas, Barczyk, Amélie, Dezitter, Xavier, Klupsch, Frédérique, Szczepanski, Fabien, Spencer, John, Chavatte, Philippe and Millet, Régis (2018) Development of novel oxazolo[5,4- d ]pyrimidines as competitive CB 2 neutral antagonists based on scaffold hopping. European Journal of Medicinal Chemistry, 146. pp. 68-78. ISSN 0223-5234
  • Khan, Raysa, Felix, Robert, Kemmitt, Paul D, Coles, Simon J, Tizzard, Graham J and Spencer, John (2018) N1-arylation of 1,4-benzodiazepine-2-ones with diaryliodonium salts. Synlett, 29 (02). pp. 193-198. ISSN 0936-5214
  • Murrell-Lagnado, Ruth (2018) A role for P2X4 receptors in lysosome function. Journal of General Physiology, 150 (2). pp. 185-187. ISSN 0022-1295
  • Almohammed, Rajaei, Osborn, Kay, Ramasubramanyan, Sharada, Naranjo Perez-Fernandez, Ijiel Barak, Godfrey, Anja, Mancini, Erika J and Sinclair, Alison J (2018) Mechanism of activation of the BNLF2a immune evasion gene of Epstein-Barr virus by Zta. Journal of General Virology, 99. pp. 805-817. ISSN 0022-1317
  • Tsaousis, Anastasios D, Hamblin, Karleigh A, Elliott, Kate, Young, Luke, Rosell Hidalgo, Alicia, Gourlay, Campbell W, Moore, Anthony and van der Giezen, Mark (2018) The human gut colonizer blastocystis respires using complex II and alternative oxidase to buffer transient oxygen fluctuations in the gut. Frontiers in Cellular and Infection Microbiology, 8 (371). pp. 1-11. ISSN 2235-2988
  • Roffe, Gavin, Boonseng, Sarote, Cox, Hazel and Spencer, John (2018) Unsymmetrical Pincer palladacycles synthesis and reactivity. In: Morales-Morales, David (ed.) Pincer compounds: chemistry and applications. Elsevier, pp. 451-466. ISBN 9780128129319
  • Ibanphylla Syiemlieh, Mrityunjaya Asthana, Sharad K. Asthana, Sunshine D. Kurbah, Angira Koch, Ram A. LalWater soluble new bimetallic catalyst [CuZn(bz)<inf>3</inf>(bpy)<inf>2</inf>]PF<inf>6</inf> in hydrogen peroxide mediated oxidation of alcohols to aldehydes/ketones and C-N functional groups December 2018, Volume878 p.48To - 59 - Journal of Organometallic Chemistry
  • Sunshine D. Kurbah, M. Asthana, I. Syiemlieh, Alzelia A. Lywait, M. Longchar, R.A. Lal, New dioxido-vanadium(V) complexes containing hydrazone ligands: Syntheses, crystal structure and their catalytic application toward CH bond functionalization, Journal of Organometallic Chemistry, Volume 876, 2018, Pages 10-16, ISSN 0022-328X, https://doi.org/10.1016/j.jorganchem.2018.08.025.
  • Sunshine D. Kurbah,M. Asthana,Ibanphylla Syiemlieh,Ram A. Lal Peroxidative catalytic oxidation of alcohols catalyzed by heterobinuclear vanadium(V) complexes using H<inf>2</inf>O<inf>2</inf> as terminal oxidizing agents https://doi.org/10.1002/aoc.4299
  • Lee, D.F., Salguero, F.J., Grainger, D. et al.Isolation and characterisation of alveolar type II pneumocytes from adult bovine lung. Sci Rep 8, 11927 (2018). https://doi.org/10.1038/s41598-018-30234-x
  • Luke Young, Mary Albury, Alice Copsey, et. al.Development of novel AOX inhibitors for fungicidal resistance management Biochimica et Biophysica Acta (BBA) - Bioenergetics 10.1016/j.bbabio.2018.09.207
  • Alicia Rosell-Hidalgo, Taravat Ghafourian, Luke Young, Anthony L Moore Prediction of AOX inhibitors from molecular structure 10.1016/j.bbabio.2018.09.200
  • Wang Y, Cai Z, Gosling M, Sheppard DN. Potentiation of the cystic fibrosis transmembrane conductance regulator Cl- channel by ivacaftor is temperature independent. Am J Physiol Lung Cell Mol Physiol. 2018 Nov 1;315(5):L846-L857. doi: 10.1152/ajplung.00235.2018. Epub 2018 Aug 23. PMID: 30136610.
• 2017
  • Sansook, Supojjanee, Ocasio, Cory A, Day, Iain J, Tizzard, Graham J, Coles, Simon, Fedorov, Oleg, Bennett, James, Elkins, Jon and Spencer, John (2017) Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety. Organic and Biomolecular Chemistry, 40 (15). pp. 8655-8660. ISSN 1477-0520 Item availability may be restricted.
  • Librizzi, Mariangela, Caradonna, Fabio, Cruciata, Ilenia, Dębski, Janusz, Supojjanee, Sansook, Dadlez, Michał, Spencer, John and Claudio, Luparello (2017) Molecular signatures associated with the treatment of triple-negative MDA-MB231 breast cancer cells with the histone deacetylase inhibitors JAHA and SAHA. Chemical Research in Toxicology, 30 (12). pp. 2187-2196. ISSN 0893-228X
  • Khan, Raysa, Boonseng, Sarote, Kemmitt, Paul, Felix, Robert, Coles, Simon J, Tizzard, Graham J, Williams, Gareth, Simmonds, Olivia, Harvey, Jessica-Lily, Atack, John, Cox, Hazel and Spencer, John (2017) Combining Sanford arylations on benzodiazepines with the nuisance effect. Advanced Synthesis and Catalysis, 359 (18). pp. 3261-3269. ISSN 1615-4150
  • Boonseng, Sarote, Roffe, Gavin W, Targema, Msugh, Spencer, John and Cox, Hazel (2017) Rationalization of the mechanism of in situ Pd(0) formation for cross-coupling reactions from novel unsymmetrical pincer palladacycles using DFT calculations. Journal of Organometallic Chemistry, 845. pp. 71-81. ISSN 0022-328X
  • Ocasio, Tony, Sansook, Supojjanee, Jones, Alice Rhiannon, Roberts, Justin, Scott, Thomas, Tsoureas, Nikolaos, Coxhead, Peter, Guille, Matthew, Tizzard, Graham J, Coles, Simon J, Hochegger, Helfrid, Bradner, James E and Spencer, John (2017) Pojamide: An HDAC3-selective ferrocene analogue with remarkably enhanced redox-triggered ferrocenium activity in cells. Organometallics, 36 (17). pp. 3276-3283. ISSN 0276-7333
  • Lineham, Ella, Spencer, John and Morley, Simon (2017) Dual abrogation of Mnk and mTOR; a novel therapeutic approach for the treatment of aggressive cancers. Future Medicinal Chemistry, 9 (13). ISSN 1756-8919
  • Khan, Raysa, Marsh, Graham, Felix, Robert, Kemmitt, Paul D, Baud, Matthias G J, Ciulli, Alessio and Spencer, John (2017) Gram scale laboratory synthesis of TC AC 28, a high affinity BET bromodomain ligand. ACS Omega, 2 (8). pp. 4328-4332. ISSN 2470-1343
  • Ansell, Melvyn B, Navarro, Oscar and Spencer, John (2017) Transition metal catalyzed element–element′ additions to alkynes. Coordination Chemistry Reviews, 336. pp. 54-77. ISSN 0010-8545 Item availability may be restricted.
  • Tuo, Wei, Leleu-Chavain, Natascha, Spencer, John, Sansook, Supojjanee, Millet, Regis and Chavatte, Philippe (2017) Therapeutic potential of fatty acid amide hydrolase, monoacylglycerol lipase, and N-acylethanolamine acid amidase inhibitors. Journal of Medicinal Chemistry, 60 (1). pp. 4-46. ISSN 0022-2623
  • Licona, Cynthia, Spaety, Marie-Elodie, Capuozzo, Antonella, Ali, Moussa, Santamaria, Rita, Armant, Olivier, Delalande, Francois, Van Dorsselaer, Alain, Cianferani, Sarah, Spencer, John, Pfeffer, Michel, Mellitzer, Georg and Gaiddon, Christian (2017) A ruthenium anticancer compound interacts with histones and impacts differently on epigenetic and death pathways compared to cisplatin. Oncotarget, 8 (2). pp. 2568-2584. ISSN 1949-2553
  • Murrell-Lagnado, Ruth D (2017) Regulation of P2X purinergic receptor signalling by cholesterol. In: Levitan, Irena (ed.) Sterol regulation of ion transport mechanisms. Current topics in membranes, 80 . Elsevier, pp. 211-232. Item availability may be restricted.
  • May, Benjamin, Young, Luke and Moore, Anthony L (2017) Structural insights into the alternative oxidases: are all oxidases made equal? Biochemical Society Transactions, 45 (3). pp. 731-740. ISSN 0300-5127 Item availability may be restricted.
  • Sunshine Dominic Kurbah, Arvind Kumar, Ibanphylla Syiemlieh, M. Asthana, Ram A. Lal, Bimetallic cis-dioxomolybdenum(VI) complex containing hydrazone ligand: Syntheses, crystal structure and catalytic studies, Inorganic Chemistry Communications, Volume 86, 2017, Pages 39-43, ISSN 1387-7003, https://doi.org/10.1016/j.inoche.2017.09.018.
  • Ritush Kumar,  Mrityunjaya Asthana, and Radhey M. SinghPd-Catalyzed One-Pot Stepwise Synthesis of Benzo[b][1,6]naphthyridines from 2-Chloroquinoline-3-carbonitriles Using Sulfur and Amines As NucleophilesJ. Org. Chem. 2017, 82, 21, 11531–11542 https://doi.org/10.1021/acs.joc.7b02147
  • Sunshine D. Kurbah, Mrityunjaya Asthana, Ibanphylla Syiemlieh and Ram A. Lal Bimetallic cis-dioxido-molybdenum(VI) complex containing multidentate hydrazone ligand catalyzed the oxidation of alcohols in biphasic medium Volume 4, Issue 3, 2017
  • Sunshine D. Kurbah, Arvind Kumar, Sankey Shangpung, Mrityunjaya Asthana, Ibanphylla Syiemlieh and Ram A. Lal Oxidation of alcohols by hydrogen peroxide catalyzed by trinuclear copper(II) complex [Cu<inf>3</inf>(slmh)(_-Cl)<inf>2</inf>(CH<inf>3</inf>OH)<inf>3</inf>].0.5CH<inf>3</inf>OH derived from disalicylaldehyde malonoyldihydrazone Volume 4, Issue 1, 2017
  • Redzej A, Ukleja M, Connery S, Trokter M, Felisberto-Rodrigues C, Cryar A, Thalassinos K, Hayward RD, Orlova EV, Waksman G. Structure of a VirD4 coupling protein bound to a VirB type IV secretion machinery. EMBO J. 2017 Oct 16;36(20):3080-3095. doi: 10.15252/embj.201796629. Epub 2017 Sep 18. PMID: 28923826; PMCID: PMC5916273
• 2016
  • Schiemann K, Blagg J, Mallinger A, Rink C, Sejberg J, Honey M.. (2016) Novel Naphthryidines and Isoquinolines and Their Use as CDK8/19 Inhibitors. WO2016009076 (A1) 20160121
  • Mallinger A, Schiemann K, Rink C, Sejberg J, Honey MA, Czodrowski P, Stubbs M, Poeschke O, Busch M, Schneider R, Schwarz D, Musil D, Burke R, Urbahns K, Workman P, Wienke D, Clarke P A, Raynaud F I, Eccles S A, Esdar C, Rohdich F, Blagg J. (2016) 2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19 Med Chem Lett, ASAP
  • Hornyak P, Askwith T, Walker S, Komulainen E, Paradowski M, Pennicott LE, Bartlett EJ, Brissett Nigel C, Raoof A, Watson M, Jordan AM, Ogilvie DJ, Ward SE, Atack JR, Pearl LH, Caldecott KW, Oliver AW (2016) Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.Biochemical Journal. ISSN 0264-6021 (Accepted)
  • Moore TO, Paradowski M, Ward SE (2016) An atom-efficient and convergent approach to the preparation of NS5A inhibitors by C–H activation. Org. Biomol. Chem. 14:3307-3313.
  • Koukoulitsa C, Villalonga-Barber C, Csonka R, Alexi X, Leonis G, Dellis D, Hamelink E, Belda O, Steele B, Micha-Screttas M, Alexis M, Papadopoulos M, Mavromoustakos T (2016). Biological and computational evaluation of resveratrol inhibitors against Alzheimer’s disease. J. Enzyme Inhib. Med. Chem. 31(1): 67-77
• 2015
  • Derudas M, Meneghesso S.(2015) The role of fluorine in antiviral drug discovery. In: Fluorinated Pharmaceuticals Advances in medicinal chemistry. Future Science Ltd, London. ISBN 9781909453968
  • Spurny R, Debaveye S, Farinha A, Veys K, Vos AM, Gossas T, Atack J, Bertrand S, Bertrand D, Danielson UH, Tresadern G, Ulens C. (2015) Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor. Proc. Natl. Acad. Sci., USA. 112(19): E2543-E2552
  • Librizzi M, Chiarelli R,Bosco L, Sansook S, Gascon JM, Spencer J, Caradonna F, Luparello C, The histone deacetylase inhibitor JAHA down-regulates pERK and global DNA methylation in MDA-MB231 breast cancer cells.Materials, 8 (10). pp. 7041-7047.
  • Coote KJ, Paisley D, Czarnecki S, Tweed M, Watson H, Young A, Sugar R, Vyas M, Smith NJ, Baettig U, Groot-Kormelink PJ, Gosling M, Lock R, Ethell B, Williams G, Schumacher A, Harris J, Abraham WM, Sabater J, Poll CT, Faller T, Collingwood SP, Danahay H. (2015) NVP-QBE170: an inhaled blocker of the epithelial sodium channel with a reduced potential to induce hyperkalaemia. Br. J. Pharmacol. 172(11): 2814-26
  • Danahay H, Pessotti AD, Coote J, Montgomery BE, Xia D, Wilson A, Yang H, Wang Z, Bevan L, Thomas C, Petit S, London A, LeMotte P, Doelemeyer A, Vélez-Reyes GL, Bernasconi P, Fryer CJ, Edwards M, Capodieci P, Chen A, Hild M, Jaffe AB. (2015) Notch2 is required for inflammatory cytokine-driven goblet cell metaplasia in the lung. Cell Rep. 10(2): 239-52
  • Bill A, Popa MO, van Diepen MT, Gutierrez A, Lilley S, Velkova M, Acheson K, Choudhury H, Renaud NA, Auld DS, Gosling M, Groot-Kormelink PJ, Gaither LA (2015). Variomics screen identifies the re-entrant loop of the calcium-activated chloride channel ANO1 that facilitates channel activation, J. Biol. Chem, 290(2): 889-903
  • Davis AM, Ward SE (2015) The Handbook of Medicinal Chemistry: Principles and Practice. Royal Society of Chemistry Print ISBN: 978-1-84973-625-1
  • Miller AT, Dahlberg C, Sandberg ML, Wen BG, Beisner DR, Hoeter JA, Parker A, Schmedt C, Stinson M, Avis J, Cienfuegos C, McPate M, Tranter P, Gosling M, Groot-Kormelink PJ, Dawson J, Pan S, Tian SS, Seidel Hm, Cooke MP (2015) Inhibition of the inositol kinase Iptkb augment calcium signalling in lymphocytes and reveals a novel strategy to treat autoimmune disease. PLoS One 10(6):e0131071
  • Pearl LH, Schierz AC, Ward SE, Al-Lazikani B, Pearl FM, (2015) Therapeutic opportunities within the DNA damage response. Nat. Rev. Cancer, 15(3):166-80
  • Ward, SE (2015) AMPA receptor positive allosteric modulators - a case history. RSC Drug Discovery Series, 39 (Ion Channel Drug Discovery), 105-134
  • Ward SE, Pennicott LE, Beswick P (2015) AMPA receptor-positive allosteric modulators for the treatment of schizophrenia: an overview of recent patent applications. Future Med. Chem., 7 (4). pp. 473-491  
• 2014
  • Arnold N, Beattie D, Bradley M, Brearley A, Brown L, Charlton SJ, Fairhurst RA, Farr D, Fozard J, Fullerton J, Gosling M, Hatto J, Janus D, Jones D, Jordan L, Lewis C, Maas J, McCarthy C, Mercer M, Oakman H, Press N, Profit R, Schuerch F, Sykes D, Taylor RJ, Trifilieff A, Tuffnell A. (2014) The identification of 7-[(R)-2-((1S,2S)-2-benzyloxycyclopentylamino)-1-hydroxyethyl]-4-hydroxybenzothiazolone as an inhaled long-acting β2-adrenoceptor agonist. Bioorg. Med. Chem. Lett. 24(7): 4341-7.
  • Atack JR, Shook BC, Rassnick S, Jackson PF, Rhodes K, Drinkenburg WH, Ahnaou A, Te Riele P, Langlois X, Hrupka B, De Haes P, Hendrickx H, Aerts N, Hens K, Wellens A, Vermeire J, Megens AA (2014) JNJ-40255293, a novel adenosine A2A/A1 antagonist with efficacy in preclinical models of Parkinson's disease. ACS Chem. Neurosci., 5(10):1005-19.
  • Bill A, Lynn Hall M, Borawski J, Hodgson C, Jenkins J, Piechon P, Popa MO, Rothwell C, Tranter P, Tria S, Wagner T, Whitehead L, Gaither LA (2014). Small Molecule Facilitated Degradation of ANO1 - a new Targeting Approach for Anticancer Therapeutics, J. Biol. Chem., 289(16): 11029-41
  • Carter E, Miron-Buchacra G, Goldoni S, Danahay H, Westwick J, Watson ML, Tosh D, Ward SG. (2014) Phosphoinositide 3-kinase alpha-dependent regulation of branching morphogenesis in murine embryonic lung: evidence for a role in determining morphogenic properties of FGF7. PLoS One. 9(12): e113555
  • Gosling M. (2014) Ion channel drug discovery – future perspectives. Ion channel drug discovery, Eds. Cox, B & Gosling M. RSC Drug Discovery. Royal Society of Chemistry ISBN 8781849731867
  • Meisenberg C, Ward SE, Schmid P, El-Khamisy SF TDP1/TOP1 ratio as a promising indicator for the response of small cell lung cancer to topotecan. J. Cancer Science & Therapy, 6(7), 258-267
  • Meisenberg C, Gilbert DC, Chalmers A, Haley V, Gollins S, Ward SE, El-Khamisy SF (2014) Clinical and Cellular Roles for TDP1 and TOP1 in Modulating Colorectal Cancer Response to Irinotecan. Mol. Cancer Ther. 14(2) : 1-11.
  • McGuigan C, Derudas M, Gonczy B, Hinsinger K, Kandil S, Pertusati F, Serpi M, Snoeck R, Andrei G, Balzarini J, McHugh TD, Maitra A, Akorli E, Evangelopoulos D, Bhakta S (2014) ProTides of N-(3-(5-(2′-deoxyuridine))prop-2-ynyl)octanamide as potential anti-tubercular and anti-viral agents.Bioorg. Med. Chem., 22(9): 2816-2824.
  • McPate M, Bhalay G, Beckett M, Fairbrother S, Gosling M, Groot-Kormelink PJ, Lane R, Kent T, Van Diepen MT, Tranter P, Verkuyl JM. (2014) The development of automated patch clamp assays for the canonical transient receptor potential channels 3, 6 and 7. Assay Drug Dev. Technol. 12(5): 282-92
  • Miller V, Gomez-Nicola D (2014) How can we exploit the brain's ability to repair itself? Expert Rev Neurother 14(12): 1345-1348
  • Rooney L, Vidal A, D’Souza A, Devereux N, Masick B, Boissel V, West R, Head V, Stringer R, Lao J, Petrus M, Patapoutian A, Nash M, Stoakley N, Panesar M, Verkuyl J, Schumacher A, Petrassi H, Tully D (2014) Discovery, Optimization, and Biological Evaluation of 5-(2-(Trifluoromethyl)phenyl)indazoles as a Novel Class of Transient Receptor Potential A1 (TRPA1) Antagonists. J. Med. Chem. 57(12): 5129–5140
  • Toti KS, Derudas M, Pertusati F, Sinnaeve D, Van der Broeck F, Margamuljana L, Martins JC, Herdewijn P, Balzarini J, McGuigan C, Van Calenbergh S. (2014) Synthesis of an apionucleoside family and discovery of a prodrug with anti-HIV activity. J. Org. Chem. 79(11): 5097-5112
  • Tran TD, Wakenhut F, Pickford C, Shaw S, Westby M, Smith-Burchnell C,Watson L, Paradowski M, Milbank J, Brimage RA, Halstead R, Glen R, Wilson CP, Adam F, Hay D, Chiva J-Y, Nichols C, Blakemore DC, Gardner I, Dayal S, Pike A, Webster R, Pryde DC. (2014) The discovery of potent nonstructural protein 5A (NS5A) inhibitors with a unique resistance profile - Part 1. ChemMedChem 9, 1378–1386
  • Walker S, Meisenberg C, Bibby RA, Askwith T, Williams G, Rininsland FH, Pearl LH, Oliver AW, El-Khamisy S, Ward S, Atack JR (2014) Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors.Anal. Biochem., 454:17-22.
  • Ward SE (2014) Neurotransmitters and other non-opiate central mechanisms. RSC Drug Discovery Series, 35 (Pain Therapeutics), 171-196.
  • Ward SE, Beswick P (2014) What does the aromatic ring number mean for drug design?Expert Opinion on Drug Discov., 9(9), 995-1003.
  • Wakenhut FT, Thien D, Pickford C, Shaw S, Westby M, Smith-Burchnell C, Watson L, Paradowski M, Milbank J, Stonehouse D, et al (2014)The Discovery of Potent Nonstructural Protein 5A (NS5A) Inhibitors with a Unique Resistance Profile-Part 2. ChemMedChem 9, 1387–1396
  • Porter DW, Bradley M, Brown Z, Charlton SJ, Cox B, Hunt P, Janus D, Lewis S, Oakley P, O'Connor D, Reilly J, Smith N, Press NJ (2014) The discovery of potent, orally bioavailable pyrimidine-5-carbonitrile-6-alkyl CXCR2 receptor antagonists.Bioorg Med Chem Lett, 24 (15):3285-3290.
  • McKeown SC, Charlton SJ, Cox B, Fitch H, Howson CD, Leblanc C, Meyer A, Rosethorne EM, Stanley E (2014) Identification of novel IP receptor agonists using historical ligand biased chemical arrays. Bioorg Med Chem Lett, 24 (10): 2247-2250.
  • Porter DW, Bradley M, Brown Z, Canova R, Charlton S, Cox B, Hunt P, Kolarik D, Lewis S, O'Connor D, Reilly J, Spanka C, Tedaldia L, Watson SJ, Wermuth R, Press NJ (2014) The discovery of potent, orally bioavailable pyrazolo and triazolopyrimidine CXCR2 receptor antagonists. Bioorg Med Chem Lett, 24(1): 72-76.
  • Honey MA, Yamashita Y, Kobayashi S (2014) A cooperative water effect in proazaphosphatrane-catalysed heterocycle synthesis. ChemComm 50(25): 3288-3291.
  • Honey MA, Moody CJ (2014) A Synthesis of Indoxylic Acid Esters by Rhodium-catalyzed Carbene N?H Insertion and Thermal Cyclization. Aust J Chem 67(8-9): 1211-1216.
  • Mortensen M, Iqbal F, Pandurangan AP, Hannan S, Huckvale R, Topf M, Baker JR, Smart TG (2014) Photo-antagonism of the GABAA receptor Nat Commun 5: 4454.
• 2013
  • Britschgi A, Bill A, Brinkhaus H, Rothwell C, Clay I, Duss S, Rebhan M, Raman P, Guy CT, Wetzel K, George E, Popa MO, Lilley S, Choudhury H, Gosling M, Wang L, Fitzgerald S, Borawski J, Baffoe J, Labow M, Gaither LA,Bentires-Alj M (2013) Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling. Proc. Natl. Acad. Sci., USA., 110(11): 4176-4177
  • Burrows AD, Jurcic M, Keenan LL, Lane RA, Mahon MF, Warren MR, Nowell H, Paradowski M, Spencer J. (2013) Incorporation by coordination and release of the iron chelator drug deferiprone from zinc-based metal-organic frameworks. Chem. Commun. 49: 11260–2 
  • Ciuclan L, Hussey MJ, Burton V, Good R, Duggan N, Beach S, Jones P, Fox R, Clay I, Bonneau O, Konstantinova I, Pearce A, Rowlands DJ, Jarai G, Westwick J, MacLean MR, Thomas M. (2013) Imatinib attenuates hypoxia-induced pulmonary arterial hypertension pathology via reduction in 5-hydroxytryptamine through inhibition of tryptophan hydroxylase 1 expression. Am. J. Respir. Crit. Care Med. 187(1):78-89.
  • Gibbs AA, Ward SE, Pennicott LE (2013) Neurodevelopmental disorders. WO2012GB52278 20120914.
  • Lavreysen H, Langlois X, Ahnaou A, Drinkenburg W, te Riele P, Biesmans I, Van der Linden I, Peeters L, Megens A, Wintmolders C, Cid J, Trabanco AA, Andrés I, Dautzenberg FM, Lütjens R, Macdonald G, Atack J (2013) Pharmacological characterization of JNJ-40068782, a new potent, selective and systemically active positive allosteric modulator of the mGlu2 receptor and its radioligand [3H]JNJ-40068782.J. Pharmacol. Exp. Therap., 346:514-527.
  • Martina K, Cravotto G, Caporaso M, Rinaldi L, Villalonga-Barber C, Ermondi G (2013) Efficient microwave-assisted synthetic protocols and in silico behaviour prediction of per-substituted β-cyclodextrins. Org. Biomol. Chem., 11 (33): 5521-5527
  • McGuigan C, Bourdin C, Derudas M, Hamon N, Hinsinger K, Kandil S, Madela K, Meneghesso S, Pertusati F, Serpi M, Slusarczyk M, Chamberlain S, Kolykhalov A, Vernachio J, Vanpouille C, Introini A, Margolis L, Balzarini J (2013) Design, synthesis and biological evaluation of phosphorodiamidate prodrugs of antiviral and anticancer nucleosides.Eur. J. Med. Chem. 70: 326-340
  • Rowe SM, Reeves G, Hathorne H, Solomon GM, Abbi S, Renard D, Lock R, Zhou P, Danahay H, Clancy JP, Waltz DA. (2013) Reduced sodium transport with nasal administration of the prostasin inhibitor camostat in subjects with cystic fibrosis. Chest. 144(1): 200-7
  • Sheldrake H, Travica S, Johansson I, Loadman P, Sutherland M, Elsalem L, Illingworth N, Cresswell A, Reuillon T, Shnyder S, Mkrtchian S, Searcey M, Sundberg M, Patterson L, Pors K (2013). Re-engineering of the Duocarmycin Structural Architecture Enables Bioprecursor Development Targeting CYP1A1 and CYP2W1 for Biological Activity. J. Med. Chem. 56: 6273–6277
  • Shinday NM, Sawyer EK, Fischer BD, Platt DM, Licata SC, Atack JR, Dawson GR, Reynolds DS, Rowlett JK (2013) Self-administration of compounds lacking intrinsic efficacy at α1 subunit-containing GABAA receptor subtypes in midazolam- but not cocaine-experienced monkeys. Psychopharmacology, 38:1006-1014
  • Villalonga-Barber C, Vallianatou K, Georgakopoulos S, Steele BR, Micha-Screttas M, Levin E, Lemcoff, GN (2013) Synthesis, characterisation, electronic spectra and electrochemical investigation of ferrocenyl-terminated dendrimers. Tetrahedron, 69 (19). pp. 3885-3895
  • Ward SE (2013) DNA Damage Repair Pathways and Synthetic Lethality. from Medicinal Chemistry Approaches to Personalized Medicine. Wiley ISBN: 978-3-527-33394-3
  • Sandham DA, Arnold N, Aschauer H, Bala K, Barker L, Brown L, Brown Z, Budd D, Cox B, Docx C, Dubois G, Duggan N, England K, Everatt B, Furegati M, Hall E, Kalthoff F, King A, Leblanc CJ, Manini J, Meingassner J, Profit R, Schmidt A, Simmons J, Sohal B, Stringer R, Thomas M, Turner KL, Walker C, Watson SJ, Westwick J, Willis J, Williams G, Wilson C (2013) Discovery and characterization of NVP-QAV680, a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases. Bioorg Med Chem Lett, 21(21): 6582-6591.
  • Laresgoiti U, Apraiz A, Olea M, Mitxelena J, Osinalde N, Rodriguez, JA, Fullaondo, A, Zubiaga, AM (2013) E2F2 and CREB cooperatively regulate transcriptional activity of cell cycle genes.Nucleic Acids Res, 41(22): 10185-10198.
• 2012
  • Beswick PJ, Gleave RJ, Hachisu S, Vile S, Bertheleme N, Ward SETetrazole compounds as calcium channel blockers. (2012) WO 2012004604 A1
  • de Courcey F, Zholos AV, Atherton-Watson H, Williams MT, Canning P, Danahay HL, Elborn JS, Ennis M. (2012) Development of primary human nasal epithelial cell cultures for the study of cystic fibrosis pathophysiology. Am. J. Physiol. Cell Physiol. 303(11): C1173-9
  • Csonka R, Villalonga-Barber C, Psycharis V, Raptopoulou CP, Steele BR (2012)Transition metal complexes of new glyoxylato-aroylhydrazones and their role in l-ascorbic acid oxidation inhibition. Polyhedron, 34 (1). pp. 181-187
  • Derudas M, McGuigan C (2012) Serendipity and VZV drug discovery. Drug Discovery Today: Technologies, 9(3): e177-e181
  • Gibbs AA, Ward SE, Pennicott LENeurodevelopmental disorders. (2012) WO 2013038200
  • Groot-Kormelink PJ, Fawcett L, Wright PD, Gosling M, Kent TC (2012) Quantitative GPCR and ion channel transcriptomics in primary alveolar macrophages and macrophage surrogates. BMC Immunol. 13, 57-66.
  • Hunt T, Atherton-Watson HC, Collingwood SP, Coote KJ, Czarnecki S, Danahay H, Howsham C, Hunt P, Paisley D, Young A. (2012) Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 2: α-Branched quaternary amines. Bioorg. Med. Chem. Lett. 22(8): 2877-9
  • Hunt T, Atherton-Watson HC, Axford J, Collingwood SP, Coote KJ, Cox B, Czarnecki S, Danahay H, Devereux N, Howsham C, Hunt P, Paddock V, Paisley D, Young A. (2012) Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 1: quaternary amines. Bioorg. Med. Chem. Lett. 22(2): 929-32
  • Lane CAL, Hay D, Mowbray CE, Paradowski M, Selby MD, Swain NA, Williams DH (2012) Synthesis of novel histamine H4 receptor antagonists. Bioorg. Med. Chem. Lett. 22, 1156–9
  • Langlois X, Lavreysen H, Atack J, Cik M, Macdonald G, Te Riele P, Peeters L, Wouters R, Megens A, Vermeire J, Hendrickx H, De Bruyn M (2012) Pharmacology of JNJ-37822681, a specific and fast-dissociating D2 antagonist for the treatment of schizophrenia.J. Pharmacol. Exp. Ther. 342:91-105
  • Mirza NR, Atack J, Wafford K (2012) GABAA receptor subtypes: Novel targets for novel medicines. Adv. Pharmacol. Sci. 529861
  • Norton D, Andreotti D, Ward SE, Profeta R, Spada S, Price HS Preparation of tricyclic piperazine containing compounds as Cav2.2 calcium channel blockers for use in pain treatment. (2012) WO 2012098400 A1
  • Ogi T, Walker S, Stiff T, Hobson E, Limsirichaikul S, Carpenter G, Prescott K, Suri M, Byrd PJ, Matsuse M, Mitsutake N, Nakazawa Y, Vasudevan P, Barrow M, Stewart GS, Taylor AM, O'Driscoll M, Jeggo PA. (2012) Identification of the first ATRIP-deficient patient and novel mutations in ATR define a clinical spectrum for ATR-ATRIP Seckel Syndrome. PLoS Genetics. 8(11):e1002945
  • Reuillon T, Bertoli A, Griffin R, Miller D, Golding B (2012) Efficacious N-protection of O-aryl sulfamates with 2,4-dimethoxybenzyl groups. Org. Biomol. Chem. 10: 7610-7617
  • Vanpouille C, Lisco A, Introini A, Grivel JC, Munawwar A, Merbah M, Schinazi RF, Derudas M, McGuigan C, Balzarini J, Margolis L (2012) Exploiting the anti-HIV-1 activity of acyclovir: suppression of primary and drug-resistant HIV isolates and potentiation of the activity by ribavirin. Antimicrob. Agents Chemother. 56(5): 2604-2611
  • Ward SE (2012) Discovery and clinical data for a novel AMPA receptor positive modulator. From RSC Drug Discovery Series 28 (Drug Discovery for Psychiatric Disorders): 99-122.
  • Bell AS, Mills JE, Williams GP, Brannigan JA, Wilkinson AJ,Parkinson T, Leatherbarrow RJ, Tate EW, Holder AA, Smith DF (2012) Selective Inhibitors of Protozoan Protein N-myristoyltransferases as Starting Points for Tropical Disease Medicinal Chemistry Programs . PLoS Negl. Trop. Dis. 6(4): e1625.
  • Bruce I, Akhlaq M, Bloomfield GC, Budd E, Cox B, Cuenoud B, Finan P, Gedeck P, Hatto J, Hayler JF, Head D, Keller T, Kirman L, Leblanc C, Le Grand D, McCarthy C, O'Connor D, Owen C, Oza MS, Pilgrim G, Press NE, Sviridenko L, Whitehead L (2012) Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway. Bioorg Med Chem Lett, 22(17): 5445-5450.
  • Honey MA , Pasceri R, Lewis W, Moody, CJ (2012) Diverse Trifluoromethyl Heterocycles from a Single PrecursorJ Org Chem 77(3): 1396-1405.
  • Davies SG, Huckvale R, Lee JA, Lorkin TJA, Roberts PM, Thomson JE (2012) Asymmetric syntheses of 3,4-syn- and 3,4-anti-3-substituted-4-aminopiperidin-2-ones: application to the asymmetric synthesis of (+)-(3S,4R)-cisapride Tetrahedron 68(15): 3263-3275.
• 2011
  • Oduor RO, Ojo KK, Williams GP, Bertelli F, Mills F, Maes L, Pryde DC, Parkinson T,Van Voorhis WC, Holler TP (2011)Trypanosoma brucei Glycogen Synthase Kinase-3, A Target for Anti-Trypanosomal Drug Development: A Public-Private Partnership to Identify Novel Leads.PLoS Negl Trop Dis5(4): e1017
  • Adam FM, Bish G, Calo F, Carr CL, Castro N, Hay D, Hodgson PB, Jones P, Knight CJ,Paradowski M, Parsons GC, Proctor KJW, Pryde DC, Rota F, Smith MC, Smith N, Tran T-D, Hitchin J, Dixon R. (2011)Development of a Practical Synthesis of Toll-like Receptor Agonist PF-4171455: 4-Amino-1-benzyl-6-trifluoromethyl-1,3-dihydroimidazo [4,5- c ] pyridin-2-one.Org. Process Res. Dev.15, 788–796
  • Atack JR(2011)GABAA receptor subtype-selective modulators. I. α2/α3-selective agonists as non-sedating anxiolytics.Curr. Top. Med. Chem.11: 1176-1202
  • Atack JR, Hallett D, Tye S, Wafford KA, Burns HD, Dawson GR, Street LJ, McKernan RM, Pike A, Agrawal NGB, van Laere K, Hargreaves RJ, Murphy MG (2011)Preclinical and clinical pharmacology of TPA023B, A GABAA receptor α2/α3 subtype-selective agonist.J. Psychopharmacol.25:329-344
  • Atack JR, Wafford KA, Street LJ, Dawson GR, McKernan RM, Agrawal NGB, van Laere K, Burns HD, Murphy MG, Hargreaves RJ (2011)MRK-409, a GABAA receptor subtype-selective agonist, is a non-sedating anxiolytic in preclinical species but causes sedation in man.J Psychopharmacol.25:315-328
  • Bicknell LS,Walker S, Klingseisen A, Stiff T, Leitch A, Kerzendorfer C, Martin CA, Yeyati P, Al Sanna N, Bober M, Johnson D, Wise C, Jackson AP, O'Driscoll M, Jeggo PA (2011).Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome.Nature Genetics. Feb 27;43(4):350-5
  • Derudas M, Pala N, Sanna V, Dallocchio R, Dessì A, Roggio AM, Sechi M (2011)Design and synthesis of novel polycycles based on the 3H-pyrrolo/6,7-dihydropyrido[1,2-a]indole scaffold as templates for pharmaceutical development.J. Heterocyclic Chem.48(5): 1161-1168
  • Egan BA,Paradowski M, Thomas LH, Marquez R (2011)Regiocontrolled rearrangement of isobenzofurans.Org. Lett.13, 2086–9
  • Egan BA,Paradowski M, Thomas LH, Marquez R (2011)Synthesis of the C1–C16 fragment of the ajudazols.Tetrahedron67, 9700–9707 (2011).
  • Fischer BD,Atack JR, Platt DM, Pike A, Reynolds DS, Dawson GR, Rowlett JK (2011)Contribution of GABAA receptors containing a3 subunits to the therapeutic-related and side effects of benzodiazepine-type drugs in monkeys.Psychopharmacol215:311-319
  • Gleave RJ, Hachisu S, Page LW,Beswick P.Spirocyclic derivatives with affinity for calcium channels. PCT Int. Appl. (2011), WO 2011141728 A1
  • Gomaa MFY, Pala N,Derudas M, Hasanen JAE, El-Tamany ESH, Casule P, Mariani A, Sechi M (2011)Investigation of furo[2,3-h]- and pyridazino[3,4-f]cinnolin-3-ol scaffolds as substrates for the development of novel HIV-1 integrase inhibitors.Arkivoc(9): 1-14
  • Hay DA, Adam FM, Bish G, Calo F, Dixon R, Fray MJ, Hitchin J, Jones P,Paradowsk M, Parsons GC, et al. (2011)A flexible synthesis of C-6 and N-1 analogues of 4-amino-1,3-dihydroimidazo[4,5-c]pyridin-2-one core.Tetrahedron Lett.52, 5728–5732.
  • Heropoulos GA,Villalonga-Barber C(2011)A clean, palladium-catalyzed oxidative esterification of aldehydes using benzyl chloride.Tetrahedron Lett., 52 (41): 5319-5322
  • Koukoulitsa C, Durdagi S, Siapi E,Villalonga-Barber C, Alexi X, Steele BR, Micha-Screttas M, Alexis MN, Tsantili-Kakoulidou A, Mavromoustakos T (2011)Comparison of thermal effects of stilbenoid analogs in lipid bilayers using differential scanning calorimetry and molecular dynamics: correlation of thermal effects and topographical position with antioxidant activity.Europ. Biophys. J., 40 (7): 865-875
  • Mowbray CE, Bell AS, Clarke NP, Collins M, Jones RM, Lane CAL, Liu WL, Newman SD,Paradowski M, Schenck EJ et al.(2011)Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: a novel histamine H4 receptor antagonist.Bioorg. Med. Chem. Lett.21, 6596–602
  • Paradowski M, Lane CAL, Peakman T (2011) Synthesis of a novel octahydro pyrrolo[3,4-c]pyrrole cyclic amidine via 1,3-dipolar cycloaddition of azomethine ylides. Synlett, 1543–1546.
  • Pryde DC, Tran T-D, Jones P, Parsons GC, Bish G, Adam FM, Smith MC, Middleton DS, Smith NN, Calo F, Hay D,Paradowski M, et al. (2011)The discovery of a novel prototype small molecule TLR7 agonist for the treatment of hepatitis C virus infection.Medchemcomm2, 185
  • Swanson DM, Wong VD, Jablonowski JA, Shah C, Rudolph DA, Dvorak CA, Seierstad M, Dvorak LK, Morton K, Nepomuceno D,Atack JR, Bonaventure P, Lovenberg TW, Carruthers NI (2011)The discovery and synthesis of JNJ 31020028, a small molecule antagonist of the Neuropeptide Y Y₂ receptor.Bioorg. Med. Chem. Lett.21: 5552-5556
  • Toti KS,Derudas M, McGuigan C, Balzarini J, Van Calenbergh S (2011)Synthesis and antiviral evaluation of α-l-2′-deoxythreofuranosyl nucleosides.Eur. J. Med. Chem., 46(9): 3704-3713
  • Villalonga-Barber C, Meligova AK, Alexi X, Steele BR, Kouzinos CE, Screttas CG, Katsanou ES, Micha-Screttas M, Alexis MN (2011)New hydroxystilbenoid derivatives endowed with neuroprotective activity and devoid of interference with estrogen and aryl hydrocarbon receptor-mediated transcription.Bioorg. Med. Chem. 19 (1): 339-351
  • Ward SE, Harries M, Aldegheri L, Austin NE, Ballantine S, Ballini E, Bradley DM, Bax BD, Clarke BP, Harris AJ, Harrison SA, Melarange RA, Mookherjee C, Mosley J, Dal Negro G, Oliosi B, Smith KJ, Thewlis KM, Woollard PM, Yusaf SP (2011)Integration of lead optimization with crystallography for a membrane-bound ion channel target: discovery of a new class of AMPA receptor positive allosteric modulators.J. Med. Chem.54 (1) : 78–94
  • Young RJ, Alderton W, Angell, AD,Beswick P, Brown D, Chambers, CL; Crowe, MC.; Dawson, J; Hamlett, CCF, Hodgson, ST, Kleanthous, S, Knowles, RG, Russell LJ, Stocker R, Woolven JM. (2011)Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase; the identification of (2R)-2-pyrrolidinecarboxamidine as a potent and selective hem-co-ordinating inhibitor.Bioorg. Med. Chem. Lett. 21(10), 3037-3040.
  • Wrigglesworth JW,Cox B, Lloyd-Jones GC, Booker-Milburn KI (2011) New heteroannulation reactions of n-alkoxybenzamides by Pd(II) catalyzed C–H activation. Org. Lett. 13(19): 5326-5329.
  • Elliott LD, Wrigglesworth JW,Cox B, Lloyd-Jones GC, Booker-Milburn KI (2011) 2,2-Difunctionalization of alkenes via Pd(II)-catalyzed Aza-Wacker reactions.Org. Lett. 13(4): 728-731.
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