Publications

2024

Park, H., Simmonds, M., Chevassut, T. J. T., & Morgan, R. (2024). Chimeric antigen receptor T-cell therapy in acute myeloid leukaemia: novel therapeutic approaches to longstanding challenges. Gene Reports, 36, pages. doi:10.1016/j.genrep.2024.101979
Article. View on figshare.
Wagstaff, M., Nguyen, D. T. T., Blair, A., Towler, B., Newbury, S., & Morgan, R. G. (2024). A β-catenin:MSI2 axis regulates the expression of<i>LEF1</i>and subsequent human haematopoietic stem/progenitor cell proliferation. doi:10.1101/2024.01.28.577638
Preprint. View online.

2022

Olaitan, S., Wagstaff, M., Sevim, O., Akieme, R., Toska, V., Humphreys, C., . . . Morgan, R. (n.d.). [Letter to the Editor] Assessment of mononuclear cell populations derived from human umbilical cord blood. European Journal of Haematology, pages. doi:10.1111/ejh.13846
Article. View on figshare.
Wongwiwat, W., Fournier, B., Bassano, I., Bayoumy, A., Karstegl, C. E., Styles, C., . . . Farrell, P. J. (n.d.). Epstein-Barr Virus genome deletions in Epstein-Barr Virus-positive T/NK cell lymphoproliferative diseases. Journal of Virology, 1-15. doi:10.1128/jvi.00394-22
Article. View on figshare.
Wagstaff, M., Tsaponina, O., Caalim, G., Greenfield, H., Harris, L., Mancini, E., . . . Morgan, R. (n.d.). Crosstalk between ß-catenin and WT1 signalling activity in acute myeloid leukemia. Haematologica, pages. doi:10.3324/haematol.2021.280294
Article. View on figshare.
Parker, C., Chambers, A. C., Flanagan, D. J., Ho, J. W. Y., Collard, T. J., Ngo, G., . . . Williams, A. C. (2022). BCL-3 loss sensitises colorectal cancer cells to DNA damage by targeting homologous recombination. DNA Repair, 115, 1-11. doi:10.1016/j.dnarep.2022.103331
Article. View on figshare.
Wagstaff, M., Coke, B., Hodgkiss, G. R., & Morgan, R. (n.d.). Targeting ß-catenin in acute myeloid leukaemia: past, present, and future perspectives. Bioscience Reports, pages. doi:10.1042/BSR20211841
Article. View on figshare.

2021

Parker, C., Chambers, A., Flanagan, D., Collard, T., Ngo, G., Baird, D., . . . Williams, A. (2021). Loss of BCL-3 sensitises colorectal cancer cells to DNA damage, revealing a role for BCL-3 in double strand break repair by homologous recombination. doi:10.1101/2021.08.03.454995
Preprint. View online.
Wagstaff, M., Tsaponina, O., Caalim, G., Greenfield, H., Milton-Harris, L., Mancini, E. J., . . . Morgan, R. G. (2021). Crosstalk between β-catenin and WT1 signalling activity in acute myeloid leukemia. doi:10.1101/2021.11.06.467095
Article. View online.

2019

Menendez-Gonzalez, J. B., Sinnadurai, S., Gibbs, A., Thomas, L. -A., Konstantinou, M., Garcia-Valverde, A., . . . Rodrigues, N. P. (2019). Inhibition of GATA2 restrains cell proliferation and enhances apoptosis and chemotherapy mediated apoptosis in human GATA2 overexpressing AML cells. Scientific Reports, 9(1), pages. doi:10.1038/s41598-019-48589-0
Article. View on figshare.
Wadley, A. J., Morgan, R., Darley, R. L., Hole, P. S., & Coles, S. J. (n.d.). Using flow cytometry to detect and measure intracellular thiol redox status in viable T cells from heterogeneous populations. Methods in Molecular Biology, 53-70. doi:10.1007/978-1-4939-9463-2_5
Article. View on figshare.
Morgan, R., Ridsdale, J., Payne, M., Heesom, K. J., Wilson, M. C., Davidson, A., . . . Darley, R. L. (2019). LEF-1 drives aberrant ß-catenin nuclear localization in myeloid leukemia cells. Haematologica, 104(7), 1365-1377. doi:10.3324/haematol.2018.202846
Article. View on figshare.
Gynn, L. E., Anderson, E., Robinson, G. M., Wexler, S. A., Upstill-Goddard, G., Cox, C., . . . May, J. E. (2019). Influence of Bone Marrow Stromal and Leukemic Cells on Cytarabine Chemo-Toxicity in Acute Myeloid Leukemia (AML). In BLOOD Vol. 134. doi:10.1182/blood-2019-122891
Conference publication. View online.

2018

Wadley, A. J., Morgan, R., Heesom, K. J., Hole, P. S., & Coles, S. J. (n.d.). Detecting intracellular thiol redox state in leukaemia and heterogeneous immune cell populations: an optimised protocol for digital flow cytometers. MethodsX, 5, 1473-1483. doi:10.1016/j.mex.2018.10.013
Article. View on figshare.
Morgan, R., Mortensson, E., & Williams, A. C. (2018). Targeting LGR5 in colorectal cancer: therapeutic gold or too plastic?. British Journal of Cancer, 118, 1410-1418. doi:10.1038/s41416-018-0118-6
Article. View on figshare.
Morgan, R., Chambers, A. C., Legge, D. N., Coles, S. J., Greenhough, A., & Williams, A. C. (2018). Optimized delivery of siRNA into 3D tumor spheroid cultures in situ. Scientific Reports, 8(7592), 1-10. doi:10.1038/s41598-018-26253-3
Article. View on figshare.
Wadley, A. J., Holliday, A., Morgan, R., Heesom, K. J., Aldred, S., Peters, D. M., . . . Coles, S. J. (2018). Preliminary evidence of reductive stress in human cytotoxic T-cells following exercise. Journal of Applied Physiology, 125(2), 586-595. doi:10.1152/japplphysiol.01137.2017
Article. View on figshare.

2017

Morgan, R., Mortensson, E., Legge, D. N., Gupta, B., Collard, T. J., Greenhough, A., & Williams, A. C. (2018). LGR5 expression is regulated by EGF in early colorectal adenomas and governs EGFR inhibitor sensitivity.. British Journal of Cancer, 118(4), 558-565. doi:10.1038/bjc.2017.412
Article. View on figshare.
Vieira, G. C., Chockalingam, S., Melegh, Z., Greenhough, A., Malik, S., Szemes, M., . . . Malik, K. (2017). Correction: LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/β-catenin signalling in neuroblastoma [Oncotarget, 6, (2015) (40053-40067)] doi: 10.18632/oncotarget.5548. Oncotarget, 8(19), 32381. doi:10.18632/oncotarget.17685
Article. View online.

2015

Vieira, G. C., Chockalingam, S., Melegh, Z., Greenhough, A., Malik, S., Szemes, M., . . . Malik, K. (2015). LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/ß-catenin signalling in neuroblastoma. Oncotarget, 6(37), 40053-40067. doi:10.18632/oncotarget.5548
Article. View on figshare.
Morgan, R., Molnár, E., Jones, R. F., Collard, T. J., Lane, J. D., Greenhough, A., . . . Williams, A. C. (n.d.). Nutrient stress alters the glycosylation status of LGR5 resulting in reduced protein stability and membrane localisation in colorectal tumour cells: implications for targeting cancer stem cells. British Journal of Cancer, 112(4), 714-719. doi:10.1038/bjc.2015.4
Article. View on figshare.

2014

Morgan, R., Ridsdale, J., Tonks, A., & Darley, R. L. (2014). Factors affecting the nuclear localization of ß-catenin in normal and malignant tissue. Journal of Cellular Biochemistry, 115(8), 1351-1361. doi:10.1002/jcb.24803
Article. View on figshare.

2013

Zabkiewicz, J., Pearn, L., Hills, R. K., Morgan, R., Tonks, A., Burnett, A. K., & Darley, R. L. (2014). The PDK1 master kinase is over-expressed in acute myeloid leukemia and promotes PKC-mediated survival of leukemic blasts. Haematologica, 99(5), 858-864. doi:10.3324/haematol.2013.096487
Article. View on figshare.
Morgan, R., Liddiard, K., Pearn, L., Pumford, S. L., Burnett, A. K., Darley, R. L., & Tonks, A. (2013). ?-Catenin is expressed throughout normal human hematopoietic development and is required for normal PU.1-dependent monocyte differentiation. Leukemia, 27(10), 2096-2100. doi:10.1038/leu.2013.96
Article. View on figshare.

2012

Morgan, R., Pearn, L., Liddiard, K., Pumford, S. L., Burnett, A. K., Tonks, A., & Darley, R. L. (2013). ?-Catenin is overexpressed in acute myeloid leukemia and promotes the stabilization and nuclear localization of ß-catenin. Leukemia, 27(2), 336-43. doi:10.1038/leu.2012.221
Article. View on figshare.

2010

Zabkiewicz, J., Pearn, L., Hills, R., Morgan, R. G., Burnett, A., Tonks, A., & Darley, R. L. (2010). PDK1 Overexpression In Acute Myeloid Leukemia; Clinical Significance and Potential as a Therapeutic Target. In BLOOD Vol. 116 (pp. 892-893). Retrieved from https://www.webofscience.com/
Conference publication.
Morgan, R. G., Pearn, L., Liddiard, K., Hills, R., Burnett, A., Tonks, A., & Darley, R. L. (2010). Distinct Regulation of β- and γ-Catenin throughout Hematopoietic Development Contrasts with Their Cooperative Roles In Acute Myeloid Leukemia. In BLOOD Vol. 116 (pp. 665-666). Retrieved from https://www.webofscience.com/
Conference publication.