This depends on where the mailing list is hosted and who runs it. Never send an email to the list itself asking to be unsubscribed, because every member of the list will see your request and this is very wasteful and annoying to others.
SUSSEX MAILING LISTS
There are three ways of leaving a mailing list, though for some mailing lists your ability to unsubscribe yourself may be controlled by the list administrator.
EXTERNAL MAILING LISTS
One of the most common off-campus mailing list services is JISCmail: to leave a list all you have to do is send a mail message to
jiscmail@jiscmail.ac.uk
with the message text
leave listname
(substitute listname with the name of the mailing list you want to leave)
For further details see the JISCmail web pages at jiscmail.ac.uk
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This is question number 652, which appears in the following categories: