Professor Majid Hafezparast

Joilin G, Leigh PN, Newbury SF, Hafezparast M (2019), An Overview of MicroRNAs as Biomarkers of ALS. Front Neurol. 7;10:186. doi: 10.3389/fneur.2019.00186.

Martinez-Macias MI, Moore DA, Green RL, Gomez-Herreros F, Naumann M, Hermann A, Van Damme P, Hafezparast M, Caldecott KW (2019), FUS (fused in sarcoma) is a component of the cellular response to topoisomeraseI-induced DNA breakage and transcriptional stress. Life Sci Alliance 26;2(2). pii: e201800222. doi:10.26508/lsa.201800222.

Trott L, Hafezparast M, Madzvamuse A (2018), A mathematical understanding of how cytoplasmic dynein walks on microtubules. Royal Society Open Science, 5 (8). p. 171568. 

De Vos KJ, Hafezparast M (2017), Neurobiology of axonal transport defects in motor neuron diseases: Opportunities for translational research? Neurobiol Dis. 105. pp. 283-299. PMID: 28235672

Chiang SC, Meagher M, Kassouf N, Hafezparast M, McKinnon PJ, Haywood R, El-Khamisy SF (2017), Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical–induced DNA damage. Science Advances, 3 (4). e1602506. PMID: 28508041

Scoto M, Rossor AM, Harms MB, Cirak , Calissano M, Robb S, Manzur AY, Martínez Arroyo A, Rodriguez Sanz A(1), Mansour S(1), Fallon P, Hadjikoumi I, Klein A, Yang M, De Visser M, Overweg-Plandsoen WC, Baas F, Taylor JP, Benatar M, Connolly AM, Al-Lozi MT, Nixon J, de Goede CG, Foley AR, Mcwilliam C, Pitt M, Sewry C, Phadke R, Hafezparast M, Chong WK, Mercuri E, Baloh RH, Reilly MM, Muntoni F. (2015), Novel mutations expand the clinical spectrum of DYNC1H1-associated spinal muscular atrophy. Neurology 84(7):668-79. PMID: 25609763

Garrett CA, Barri M, Kuta A, Soura V, Deng W, Fisher EM, Schiavo G, Hafezparast M. (2014), DYNC1H1 mutation alters transport kinetics and ERK1/2-cFos signalling in a mouse model of distal spinal muscular atrophy. Brain 137:1883-93. PMID: 24755273. 

Caroll J, Page TK, Chiang SC, Kalmar B, Bode D, Greensmith L, McKinnon PJ, Thorpe JR, Hafezparast M*, El-Khamisy SF. (2014), Expression of a pathogenic mutation of SOD1 sensitises aprataxin deficient cells and mice to oxidative stress and triggers hallmarks of premature ageing. Hum Mol Genet. 24(3):828-40. PMID: 25274775. *Co-PI.

Rulten SL, Rotheray A, Green RL, Grundy GJ, Moore DA, Gómez-Herreros F, Hafezparast M*, Caldecott KW. (2014), PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage. Nucleic Acids Res. 42(1):307-14. PMID: 24049082. *Co-PI.

Schiavo G, Greensmith L, Hafezparast M, Fisher EM. (2013), Cytoplasmic dynein heavy chain: the servant of many masters. Trends Neurosci. 36(11):641-51. PMID: 24035135.

Oates EC, Rossor AM, Hafezparast M, et al. (2013), Mutations in BICD2 Cause Dominant Congenital Spinal Muscular Atrophy and Hereditary Spastic Paraplegia, Am J Hum Genet. 92(6):965-73. PMID: 23664120

Crossley L, Garrett CA, Hafezparast M, Madzvamuse A (2012), From the Cell Membrane to the Nucleus: Unearthing Transport Mechanisms for Dynein. Bull Math Biol. 74(9):2032-61 PMID: 22791512.

Rosse C, Boeckeler K, Linch M, Radtke S, Frith D, Barnouin K, Morsi AS, Hafezparast M, Howell M, Parker PJ. (2012), Binding of dynein intermediate chain 2 to paxillin controls focal adhesion dynamics and migration, J Cell Sci. 15;125(Pt 16):3733-8. PMID: 22553211

Acevedo-Arozena A, Kalmar B, Essa S, Ricketts T, Joyce P, Kent R, Rowe C, Parker A, Gray A, Hafezparast M, et al (2011), A comprehensive assessment of the SOD1G93A low-copy transgenic mouse, which models human amyotrophic lateral sclerosis. Dis Model Mech. 4(5):686-700 PubMed PMID: 21540242.

Banks GT, Haas MA, Line S, Shepherd HL, Alqatari M, Stewart S, Rishal I, Philpott A, Kalmar B, Kuta A, Groves M, Parkinson N, Acevedo-Arozena A, Brandner S, Bannerman D, Greensmith L, Hafezparast M, et al. (2011), Behavioral and other phenotypes in a cytoplasmic Dynein light intermediate chain 1 mutant mouse. J Neurosci. 31(14):5483-94. PubMed PMID: 21471385;

Eschbach J, Fergani A, Oudart H, Robin JP, Rene F, Gonzalez de Aguilar JL, Larmet Y, Zoll J, Hafezparast M et al. (2011), Mutations in cytoplasmic dynein lead to a Huntington's disease-like defect in energy metabolism of brown and white adipose tissues. Biochim Biophys Acta. 1812(1):59-69. Epub 2010 Sep 29. PubMed PMID: 20887786.

Deng W, Garrett C, Dombert B, Soura V, Banks G, Fisher EM, van der Brug MP, Hafezparast M. (2010) Neurodegenerative mutation in cytoplasmic dynein alters its organization and dynein-dynactin and dynein-kinesin interactions. J Biol Chem. 285(51):39922-34. PubMed PMID: 20889981; PubMed Central PMCID: PMC3000974.

El-Kadi AM, Bros-Facer V, Deng W, Philpott A, Stoddart E, Banks G, Jackson GS, Fisher EM, Duchen MR, Greensmith L, Moore AL, Hafezparast M (2010), The legs at odd angles (Loa) mutation in cytoplasmic dynein ameliorates mitochondrial function in SOD1G93A mouse model for motor neuron disease. J Biol Chem. 285(24):18627-39. PubMed PMID: 20382740; PubMed Central PMCID: PMC2881788.

Kuta A, Deng W, Morsi El-Kadi A, Banks GT, Hafezparast M, Pfister KK, Fisher EM (2010), Mouse cytoplasmic dynein intermediate chains: identification of new isoforms, alternative splicing and tissue distribution of transcripts. PLoS One 5(7):e11682. Erratum in: PLoS One. 2010;5(10). doi: 10.1371/annotation/59badad8-6e55-46f8-8bf1-7a8a957bc68e. PubMed PMID: 20657784; PubMed Central PMCID: PMC2908135.

Ateh DD, Hussain IK, Mustafa AH, Price KM, Gulati R, Nickols CD, Bird MM, Greensmith L, Hafezparast M, et al. (2008), Dynein-dynactin complex subunits are differentially localized in brain and spinal cord, with selective involvement in pathological features of neurodegenerative disease. Neuropathol Appl Neurobiol. 34(1):88-94. Epub 2007 Dec 10. PubMed PMID: 18086204.

Bowen S, Ateh DD, Deinhardt K, Bird MM, Price KM, Baker CS, Robson JC, Swash M, Shamsuddin W, Kawar S, El-Tawil T, Roos J, Hoyle A, Nickols CD, Knowles CH, Pullen AH, Luthert PJ, Weller RO, Hafezparast M, et al (2007), The phagocytic capacity of neurones. Eur J Neurosci. 25(10):2947-55. PubMed PMID: 17561810.

Myers KR, Lo KW, Lye RJ, Kogoy JM, Soura V, Hafezparast M, Pfister KK (2007), Intermediate chain subunit as a probe for cytoplasmic dynein function: biochemical analyses and live cell imaging in PC12 cells. J Neurosci Res. 85(12):2640-7. PubMed PMID: 17279546.

El-Kadi AM, Soura V, Hafezparast M (2007), Defective axonal transport in motor neuron disease. J Neurosci Res. 85(12):2557-66. Review. PubMed PMID: 17265455.

Achilli F, Boyle S, Kieran D, Chia R, Hafezparast M, et al. (2005), The SOD1 transgene in the G93A mouse model of amyotrophic lateral sclerosis lies on distal mouse chromosome 12. Amyotroph Lateral Scler Other Motor Neuron Disord. 6(2):111-4. PubMed PMID: 16036435.

Kieran D, Hafezparast M, et al. (2005) A mutation in dynein rescues axonal transport defects and extends the life span of ALS mice. J Cell Biol. 169(4):561-7. PubMed PMID: 15911875; PubMed Central PMCID: PMC2171702.

Hafezparast M, et al. (2005), Prion disease incubation time is not affected in mice heterozygous for a dynein mutation. Biochem Biophys Res Commun. 326(1):18-22. PubMed PMID: 15567146.

Hafezparast M, et al. (2003), Paradigms for the identification of new genes in motor neuron degeneration. Amyotroph Lateral Scler Other Motor Neuron Disord. 4(4):249-57. PubMed PMID: 14753659.

Ahmad-Annuar A, Shah P, Hafezparast M, et al. (2003), No association with common Caucasian genotypes in exons 8, 13 and 14 of the human cytoplasmic dynein heavy chain gene (DNCHC1) and familial motor neuron disorders. Amyotroph Lateral Scler Other Motor Neuron Disord. 4(3):150-7. PubMed PMID: 13129801.

Hafezparast M, et al. (2002), Mouse models for neurological disease. Lancet Neurol; 1(4):215-24. Review. PubMed PMID: 12849454.

Hafezparast M, et al. (2003), Mutations in dynein link motor neuron degeneration to defects in retrograde transport. Science; 300 (5620):808-12. PubMed PMID: 12730604.

Hafezparast M, et al. (2002), A new mouse mutant, skijumper. Mamm Genome; 13(7):359-364. PubMed PMID: 12152619.

Witherden AS, Hafezparast M, et al. (2002), An integrated genetic, radiation hybrid, physical and transcription map of a region of distal mouse chromosome 12, including an imprinted locus and the 'Legs at odd angles' (Loa) mutation. Gene; 283(1-2):71-82. PubMed PMID: 11867214.

Hafezparast M (2001), NF1 mice: smaller brains but no tumours. Trends Mol Med; 7(7):285. PubMed PMID: 11425624.

Rogers DC, Peters J, Martin JE, Ball S, Nicholson SJ, Witherden AS, Hafezparast M, et al. (2001), SHIRPA, a protocol for behavioral assessment: validation for longitudinal study of neurological dysfunction in mice. Neurosci Lett; 306(1-2):89-92. PubMed PMID: 11403965.

Hafezparast M. (2000), Caspases and neurodegenerative diseases. Mol Med Today; 6(9):338. PubMed PMID: 11202967.

Nicholson SJ, Witherden AS, Hafezparast M, Martin JE, Fisher EM (2000), Mice, the motor system, and human motor neuron pathology. Mamm Genome; 11(12):1041-52. Review. PubMed PMID: 11130970.

Beck JA, Lloyd S, Hafezparast M, et al. (2000), Genealogies of mouse inbred strains. Nat Genet.; 24(1):23-5. PubMed PMID: 10615122.

Hafezparast M, et al. (1999), The kinesin light chain gene: its mapping and exclusion in mouse and human forms of inherited motor neuron degeneration. Neurosci Lett.; 273(1):49-52. PubMed PMID: 10505649.

Hafezparast M, Fisher E (1998), Wasted by an elongation factor. Trends Genet.; 14(6):215-7. PubMed PMID: 9635401.

Wang X, Hafezparast M, Masters JR (1997), Complementation analysis of testis tumor cells. Cancer Genet Cytogenet.; 98(1):56-62. PubMed PMID: 9309119.

Wang X, Hafezparast M, Masters JR (1996), Genetic basis of drug sensitivity in human testis tumour cells. Int J Cancer; 65(4):426-31. PubMed PMID: 8621221.

Blunt T, Taccioli GE, Priestley A, Hafezparast M, et al. (1995), A YAC contig encompassing the XRCC5 (Ku80) DNA repair gene and complementation of defective cells by YAC protoplast fusion. Genomics; 30(2):320-8. PubMed PMID: 8586433.

Hafezparast M et al. (1994), An extended panel of hamster-human hybrids for chromosome 2q. Somat Cell Mol Genet.; 20(6):541-8. PubMed PMID: 7892651.

Hafezparast M, et al. (1993), Subchromosomal localization of a gene (XRCC5) involved in double strand break repair to the region 2q34-36. Somat Cell Mol Genet.; 19(5):413-21. PubMed PMID: 8291019.

Jeggo PA, Hafezparast M, et al. (1993) A hamster-human subchromosomal hybrid cell panel for chromosome 2. Somat Cell Mol Genet.; 19(1):39-49. PubMed PMID: 8460397.

Jeggo PA, Hafezparast M, et al. (1992), Localization of a DNA repair gene (XRCC5) involved in double-strand-break rejoining to human chromosome 2. Proc Natl Acad Sci U S A.; 89(14):6423-7. PubMed PMID: 1631138; PubMed Central PMCID: PMC49513.