ARR 2014 Provisional Programme
Fulton Building
University of Sussex
Brighton BN1 9RQ
contact: Penny Jeggo or ARR@sussex.ac.uk
Sunday 29th June |
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| 4.30 - 6.30 pm | Arrival and registration: GDSC Building, University of Sussex |
Monday 30th June |
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| 9.00 -10.15 am | Arrival and registration: Fulton Building, University of Sussex |
Session 1 |
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10.15 - 12.30pm DNA repair and chromatin changes |
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| 10.15-11.00am | Opening speaker: Steve Jackson, University of Cambridge |
| Assembly and disassembly of protein complexes at sites of DNA damage | |
| 11.00-11.30am | Markus Lobrich, Darmstadt, Germany |
| Regulating DNA double-strand break resection during the mammalian cell cycle | |
| 11.30-12.00am | Kienan Savage, Queen's University of Belfast, UK |
| A novel BRCA1 associated mRNA splicing complex required for efficient DNA repair and maintenance of genomic stability | |
| 12.00-12.15am | Vincenzo D'Angiolella, University of Oxford. |
| Insights into Ribonucleotide Reductase (RNR) regulation during cell cycle progression and DNA damage respoonse | |
| 12.15-12.30pm | Peter Brownlee, University of Sussex. BAF180 promotes cohesion adn prevents genome instability and aneuploidy. |
12.30 - 2.00 lunch + poster viewing |
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Session 2 |
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2.00 - 3.30pm Cellular effects and imaging approaches |
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| 2.00 - 2.45 pm | Marco Durante, GSI Helmholtz Center and Technical University of Darmstadt, Germany |
| Cellular radiobiology for hypofractionated particle therapy | |
Talk sponsored by the EACR |
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| 2.45 - 3.15 pm | Tim Humphrey. University of Oxford. |
| Histone H3K36 trimethylation facilitates homologous recombination repair and genome stability. | |
| 3.15 - 3.30 pm | Rhona Anderson, Brunel University |
| DNA DSBs are induced linearly and processed efficiently in non-aged normal human bronchial lung epithelial cells. | |
3.30 - 4.00pm coffee |
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Session 3 |
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4.00 - 5.30pm Tissue effects and response modelling |
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| 4.00 - 4.30 pm | Helen Bryne, University of Oxford |
| Mathematical Modelling: A Potent Weapon for Treating Solid Tumours? | |
| 4.30 - 5.00 pm | Melda Tozluoglu, UCL UK |
| Plassticity of the cancer cell migration: Extracellular matrix drives the optimisation of blebbing, adhesions and spreading | |
| 5.00 - 5.30 pm | Marion Scharpfenecker, NKI, Amsterdam |
| Inflammation in late renal toxicity: friend or foe. | |
Tuesday 1st July |
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Session 4 |
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9.00 - 10.30pm Biomarkers for screening or radiation response identification |
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| 9.00 - 9.30am | John Waterton, University of Manchester and AstraZeneca, UK |
| Imaging biomarkers for early response assessment in cancer therapy | |
| 9.30 - 10.00am | Kai Rothkamm, PHE |
| Cytogenetic and DNA double-strand break biomarkers of radiation exposure and individual radiosensitivity | |
| 10.00-10.20am | Omid Azimzadeh, Helmholtz Zentrum Munchen, Institute of Radiation Biology, Munich, Germany |
| Interaction between cardiac and hepatic proteome after low total body or high local cardiac irradiation using different mouse models | |
| 10.20-10.35am | Cynthia Eccles, University of Oxford. |
| In vivo validation of changes in phospho-Akt in normal tissues following radiosensitisation with Plk3/mTOR inhibitors. | |
10.30 - 11.00am Coffee |
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Session 5 |
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11.00 - 12.20pm Low doses irradiation and Radiation Protection |
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| 11.00-11.30am | Mark Pearce, University of Newcastle |
| Cancer risks following CT scans in childhood or early adulthood | |
| 11.30-12.00am | Michael Hauptmann, NKI, The Netherlands |
| What to expect from ongoing European studies of CT-related cancer risks | |
Talk sponsored by the AICR |
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| 12.00-12.30pm | Gerry Kendall, University of Oxford |
| Natural ionizing radiation exposure and childhood cancer | |
12.30 - 2.00pm Lunch and Poster viewing |
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| 1.00-200pm |
ARR AGM |
Session 6 |
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3.00 - 4.30pm Enhancing radiotherapy. Session sponsored by CTRad |
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| 2.00 - 2.30 pm | Ester Hammond, Oxford, UK |
| Targeting hypoxic tumour cells through the DNA damage response | |
| 2.30 - 3.00 pm | Marc Vooijs, Maastricht, The Netherlands |
| NOTCH signaling in cancer and therapy resistance | |
| 3.00 - 3.15 pm | Christopher Talbot, Leicester University, UK |
| The REQUITE project: Validating predictive models and biomarkers of radiotherapy toxicity to reduce side effects and improve quality of life in cancer survivors | |
| 3.15 - 3.30 pm | Karl Butterworth, Queen's University of Belfast, UK |
| In vitro/in vivo characterisation of radiation induced signallig effects towards biologically optimised radiotherapy. | |
3.30 - 4.00 pm Coffee |
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4.00 - 5.30 pm SIT session . Chairs: Pheobe Lam and Jane Bryant. |
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| 4.00 - 4.15 pm | Dafni-Eleftheria Pefani, Oncology Department, University of Oxford |
| RassF1A/Lats1 pathway regulates CDK2-BRCA2 dependent replication fork stability. | |
| 4.15 - 4.30 pm | Lara Barazzuol, GDSC, University of Sussex |
| DNA damage arises in adult neuronal cells and sensitively activates apoptosis in the subventricular zone stem cell compartment after low dose radiation | |
| 4.30 - 4.45 pm | Ann-Sofie Schreurs, NASA, US |
| The role of oxidative damage in radiation-induced bone loss. | |
| 4.45 - 5.00 pm | Sarah Jevons, Oncology Department, University of Oxford, UK |
| Clinically relevant MRE11 variants in bladder cancer. | |
| 5.00 - 5.15 pm | Simon Horn, Queen's University of Belfast, UK |
| Alpha particle induced pan nuclear phosphorylation of H2AX and ATM in cells driven through chromatin remodelling. | |
| 5.15 - 5.30 pm | Grainne Manning, Public Health England, UK |
| Quantifying murine bone marrow blood radiation dose response following 18F-FDG PET with biomarkers | |
| 6.45 pm | Drinks reception |
| 7.00 pm | Prior to dinner: |
| Mike Atkinson, Munich, Germany– Weiss Medal Award Lecture | |
| The more we discover, the less we understand: The ever-changing biology of radiation | |
Sponsorship by ERR |
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| 8.00 pm | Conference dinner |
| 9.30 pm | Dancing to Seaford Rock and Jazz Orchestra |
Wednesday 2nd July |
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Session 7 |
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9.00 - 10.30am Tumour microenvironment |
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| 9.00 - 9.30 am | Ruth Muschel, University of Oxford, UK |
| Tumour-vascular interaction:implications for radiation therapy. | |
| 9.30 - 10.00am | Andy Ryan, University of Oxford, UK |
| The influence of microenvironment on the antitumour effects of PARP inhibition in combination with radiation | |
| 10.00-10.15 am | Iosifina Foskolou, University of Oxford, UK |
| RRM2B: oxygen-requiring protein induced in hypoxia | |
| 10.00-10.30 am | Kaye Williams, University of Manchester, UK |
| Analysing the effects of radiotherapy on the metastic phenotype in vivo: A role for combined therapeutic approaches incorporating Src and PI3K targeting. | |
10.30 - 11.00am Coffee |
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Session 8 |
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11.00 - 12.30pm Nuclear Medicine. |
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| 11.00-11.30am | Kate Vallis, Oxford University, UK |
| Radionuclide imaging and therapy using targeted nano particles | |
| 11.30-12.00am | Jonathan Coulter, School of Pharmacy, Belfast |
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Enhanced radiation sensitivity using antagonistic, lipophilic pepducins: opportunities for novel radiosensitisers. |
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| 12.00-12.15pm | Munira Kadhim, Oxford Brrokes University. |
| Non-targeted effects of Ionizing radiation: Recent advance in understanding the mechanisms and impacts | |
| 12.15-12.30pm | Mark Hill, University of Oxford. |
| The anatomy of an alpha-particle track and implications for biological response. | |
12.30 - 2.30pm Lunch and poster viewing |
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Session 9 |
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2.30 - 4.15pm Stem cells |
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| 2.30 - 3.15pm | Martin Brown: Stanford University, US |
| Circulating monocytes promote tumour radioresistance | |
| 3.15 - 3.45pm | Eric O`Neill, University of Oxford |
| Epigenetic control of "stemness" and associated therapeutic resistance in tumours. - RASSF1A regulatin of the hippo stem cell pathway | |
| 3.45 - 4.15pm | Tracy Robson, Queen's University of Belfast, UK |
| Targeting angiogenesis and treatment resistant cancer stem cells with FKBPL and its therapeutic peptide derivatives, AD-01/ALM201 | |
4.15pm End of meeting |
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