Life Sciences

Regulating Gene Expression

Module code: C7132
Level 6
15 credits in autumn semester
Teaching method: Lecture, Seminar
Assessment modes: Computer based exam, Coursework

On this module, you'll take a current perspective of the molecular mechanisms controlling RNA expression in eukaryotes, focusing largely on gene transcription and translation but also RNA processing and regulation by non-coding RNAs.

You will explore how eukaryotic transcriptional regulators control RNA polymerase recruitment and retention and modulate chromatin structure during transcriptional activation and repression. You will also focus on mechanisms of post-transcriptional gene control and protein translation.

Understanding these processes and mechanisms is fundamental for your understanding of the regulation of normal cell growth and how it can become deregulated in diseases like cancer.

Module learning outcomes

• Develop a systematic understanding of the fundamental principles and advanced concepts in gene expression regulation and non-coding RNA activity, integrating coherent and detailed knowledge from the forefront of current research in the field.
• Acquire proficiency in deploying accurately established techniques of analysis and inquiry within the discipline of gene expression regulation, demonstrating the ability to critically assess research methodologies and experimental approaches.
• Develop a deep conceptual understanding that enables to formulate sophisticated arguments, solve complex problems, and engage in advanced discussion using cutting-edge ideas and techniques from the discipline of regulating gene expression.
• Enhance the ability to autonomously employ effective strategies to understand and contextualise peer-reviewed research articles and review articles. Develop the skills to critically evaluate and synthesise information from diverse sources, including original materials pertinent to this discipline