Life Sciences

Cell Signalling and Therapeutics

Module code: C7118
Level 6
15 credits in autumn semester
Teaching method: Lecture
Assessment modes: Computer based exam, Coursework

Explore the major signalling pathways in cells, and how perturbations of these can result in disease processes such as cancer.

You will learn how knowledge of these pathways has led to the design and use of specific pharmacological agents, targeting the pathways for therapeutic intervention.

The signalling pathways covered will include:

• RTKs
• LMTK3
• MAPK kinase pathways
• PI-3-kinase and PKB
• Jak/Stat pathways
• integrins.

Module learning outcomes

• Summarise the major types of signalling pathways in the cell and explain the mechanisms underlying the activation and regulation of these pathways in breast and brain cancers.
• Appraise how multiple signalling pathways interact to produce a co-ordinated response to external stimuli within the body, promoting cell proliferation, survival and movement
• Illustrate how dysregulation in these pathways results in a loss of growth control and the development of cancer.
• Apply your knowledge of cell signalling to explain the rational design of therapeutic agents targeting these pathways in disease processes.