Paul Tofts
Emeritus Professor (Brighton and Sussex Medical School)

Selected publications

Article

Dowell, Nicholas G, Evans, Simon L, Tofts, Paul S, King, Sarah L, Tabet, Naji and Rusted, Jennifer M (2016) Structural and resting-state MRI detects regional brain differences in young and mid-age healthy APOE-e4 carriers compared with non-APOE-e4 carriers. NMR in Biomedicine, 29 (5). pp. 614-624. ISSN 0952-3480

Evans, Simon, Dowell, Nicholas G, Tabet, Naji, Tofts, Paul Stephen, King, Sarah L and Rusted, Jennifer M (2014) Cognitive and neural signatures of the APOE E4 allele in mid-aged adults. Neurobiology of Aging, 35 (7). pp. 1615-23. ISSN 0197-4580

Evans, Simon, Dowell, Nicholas G, Tabet, Naji, Tofts, Paul S, King, Sarah L, Gray, Marcus and Rusted, Jennifer M (2013) Nicotine effects on attentional reorienting in mid-age adults, and interactions with apolipoprotein E status. Journal of Psychopharmacology, 27 (11). pp. 1007-14. ISSN 0269-8811

Dowell, Nicholas G, Ruest, Torsten, Evans, Simon L, King, Sarah L, Tabet, Naji, Tofts, Paul S and Rusted, Jennifer M (2013) MRI of carriers of the apolipoprotein E e4 allele-evidence for structural differences in normal-appearing brain tissue in e4+ relative to e4- young adults. NMR in Biomedicine, 26 (6). pp. 674-682. ISSN 0952-3480

Simpson, Andrew R H, Dowell, Nicholas G, Jackson, Timothy L, Tofts, Paul S and Hughes, Edward H (2013) Measuring the effect of pars plana vitrectomy on vitreous oxygenation using magnetic resonance imaging. Investigative Ophthalmology & Visual Science, 54 (3). pp. 2028-2034. ISSN 0146-0404

Rusted, J M, Evans, S L, King, S L, Dowell, N G, Tabet, N and Tofts, P S (2013) APOE e4 polymorphism in young adults is associated with improved attention and indexed by distinct neural signatures. NeuroImage, 65 (1). pp. 364-373. ISSN 1053-8119

Evans, Simon, Gray, Marcus A, Dowell, Nicholas, Tabet, Naji, Tofts, Paul S, King, Sarah and Rusted, Jennifer M (2012) APOE E4 carriers show prospective memory enhancement under nicotine, and evidence for specialisation within medial BA10. Neuropsychopharmacology, 38 (4). pp. 655-663. ISSN 0893-133X

Tofts, Paul S, Chevassut, Timothy, Cutajar, Marica, Dowell, Nicholas G and Peters, A Michael (2011) Doubts concerning the recently reported human neutrophil lifespan of 5.4 days. Blood, 117 (22). pp. 6050-6052. ISSN 0006-4971

Tofts, Paul S, Jackson, Jonathan S, Tozer, Daniel J, Cercignani, Mara, Keir, Geoffrey, MacManus, David G, Ridgway, Gerard R, Ridha, Basil H, Schmierer, Klaus, Siddique, Durre, Thornton, John S, Wroe, Stephen J and Fox, Nick C (2008) Imaging cadavers: cold FLAIR and noninvasive brain thermometry using CSF diffusion. Magnetic Resonance in Medicine, 59 (1). pp. 190-195. ISSN 1522-2594

Dowell, Nicholas G. and Tofts, Paul S. (2007) Fast, accurate, and precise mapping of the RF field in vivo using the 180 degrees signal null. Magnetic Resonance in Medicine, 58 (3). pp. 622-630. ISSN 0740-3194

Schmierer, K., Wheeler-Kingshott, C. A., Boulby, P. A., Scaravilli, F., Altmann, D. R., Barker, G. J., Tofts, P. S. and Miller, D. H. (2007) Diffusion tensor imaging of post mortem multiple sclerosis brain. Neuroimage, 35 (2). pp. 467-477. ISSN 1053-8119 (Print)

Tofts, Paul Stephen, Benton, Christopher E., Weil, Rimona S., Tozer, Daniel J., Altmann, Daniel R., Jager, H. Rolf, Waldman, Adam D. and Rees, Jeremy H. (2007) Quantitative analysis of whole-tumor Gd enhancement histograms predicts malignant transformation in low-grade gliomas. Journal of Magnetic Resonance Imaging, 25 (1). pp. 208-214. ISSN 1053-1807

Samson, R. S., Thornton, J. S., McLean, M. A., Williams, S. C. and Tofts, P. S. (2006) 1H-MRS internal thermometry in test-objects (phantoms) to within 0.1 K for quality assurance in long-term quantitative MR studies. NMR in Biomedicine, 19 (5). pp. 560-565. ISSN 0952-3480

Tozer, D. J, Davies, G. R., Altmann, D. R., Miller, D. H. and Tofts, P. S. (2006) Principal component and linear discriminant analysis of T1 histograms of white and grey matter in multiple sclerosis. Magnetic Resonance Imaging, 24 (6). pp. 793-800. ISSN 0730-725X

Tofts, P. S., Steens, S. C., Cercignani, M., Admiraal-Behloul, F., Hofman, P. A., van Osch, M. J., Teeuwisse, W. M., Tozer, D. J., van Waesberghe, J. H., Yeung, R., Barker, G. J. and van Buchem, M. A. (2006) Sources of variation in multi-centre brain MTR histogram studies: body-coil transmission eliminates inter-centre differences. Magnetic Resonance Materials in Physics, Biology and Medicine, 19 (4). pp. 209-22. ISSN 0968-5243

Samson, R. S., Wheeler-Kingshott, C. A., Symms, M. R., Tozer, D. J. and Tofts, P. S. (2006) A simple correction for B1 field errors in magnetization transfer ratio measurements. Magnetic Resonance Imaging, 24 (3). pp. 255-263. ISSN 0730-725X

Tozer, D. J., Davies, G. R., Altmann, D. R., Miller, D. H. and Tofts, P. S. (2005) Correlation of apparent myelin measures obtained in multiple sclerosis patients and controls from magnetization transfer and multicompartmental T2 analysis. Magnetic Resonance in Medicine, 53 (6). pp. 1415-1422. ISSN 0740-3194

Trick, G. L., Liggett, J., Levy, J., Adamsons, I., Edwards, P., Desai, U., Tofts, P. S. and Berkowitz, B. A. (2005) Dynamic contrast enhanced MRI in patients with diabetic macular edema: initial results. Experimental Eye Research, 81 (1). pp. 97-102. ISSN 0014-4835

Davies, G. R., Altmann, D. R., Hadjiprocopis, A., Rashid, W., Chard, D. T., Griffin, C. M., Tofts, P. S., Barker, G. J., Kapoor, R., Thompson, A. J. and Miller, D. H. (2005) Increasing normal-appearing grey and white matter magnetisation transfer ratio abnormality in early relapsing-remitting multiple sclerosis. Journal of Neurology, 252 (9). pp. 1037-1044. ISSN 0340-5354

Tofts, P. S., Silver, N. C., Barker, G. J. and Gass, A. (2005) Object strength - an accurate measure for small objects that is insensitive to partial volume effects. Magnetic Resonance Materials in Physics, Biology and Medicine, 18 (3). pp. 162-169. ISSN 0968-5243

Hadjiprocopis, A., Rashid, W. and Tofts, P. S. (2005) Unbiased segmentation of diffusion-weighted magnetic resonance images of the brain using iterative clustering. Magnetic Resonance Imaging, 23 (8). pp. 877-885. ISSN 0730-725X

Leach, M. O., Brindle, K. M., Evelhoch, J. L., Griffiths, J. R., Horsman, M. R., Jackson, A., Jayson, G. C., Judson, I. R., Knopp, M. V., Maxwell, R. J., McIntyre, D., Padhani, A. R., Price, P., Rathbone, R., Rustin, G. J., Tofts, P. S., Tozer, G. M., Vennart, W., Waterton, J. C., Williams, S. R. and Workman, P. (2005) The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: issues and recommendations. British Journal of Cancer, 92 (9). pp. 1599-1610. ISSN 0007-0920

Barker, G. J., Schreiber, W. G., Gass, A., Ranjeva, J. P., Campi, A., van Waesberghe, J. H., Franconi, J. M., Watt, H. C. and Tofts, P. S. (2005) A standardised method for measuring magnetisation transfer ratio on MR imagers from different manufacturers - the EuroMT sequence. Magnetic Resonance Materials in Physics, Biology and Medicine, 18 (2). pp. 76-80. ISSN 0968-5243

Rashid, W., Parkes, L. M., Ingle, G. T., Chard, Daniel, Toosy, A. T., Altmann, D. R., Symms, M. R., Tofts, P. S., Thompson, A. J. and Miller, D. H. (2004) Abnormalities of cerebral perfusion in multiple sclerosis. Journal of Neurology, Neurosurgery and Psychiatry, 75 (9). pp. 1288-1293. ISSN 0022-3050

Johnson, G., Wetzel, S. G., Cha, S., Babb, J. and Tofts, P. S. (2004) Measuring blood volume and vascular transfer constant from dynamic, T(2)*-weighted contrast-enhanced MRI. Magnetic Resonance in Medicine, 51 (5). pp. 961-968. ISSN 0740-3194

Parkes, L. M., Rashid, W., Chard, D. T. and Tofts, P. S. (2004) Normal cerebral perfusion measurements using arterial spin labeling: reproducibility, stability, and age and gender effects. Magnetic Resonance in Medicine, 51 (4). pp. 736-743. ISSN 0740-3194

Leach, M. O., Brindle, K. M., Evelhoch, J. L., Griffiths, J. R., Horsman, M. R., Jackson, A., Jayson, G., Judson, I. R., Knopp, M. V., Maxwell, R. J., McIntyre, D., Padhani, A. R., Price, P., Rathbone, R., Rustin, G., Tofts, P. S., Tozer, G. M., Vennart, W., Waterton, J. C., Williams, S. R. and Workman, P. (2003) Assessment of antiangiogenic and antivascular therapeutics using MRI: recommendations for appropriate methodology for clinical trials. British Journal of Radiology, 76. pp. 87-91. ISSN 0007-1285

Dyke, J. P., Panicek, D. M., Healey, J. H., Meyers, P. A., Huvos, A. G., Schwartz, L. H., Thaler, H. T., Tofts, P. S., Gorlick, R., Koutcher, J. A. and Ballon, D. (2003) Osteogenic and Ewing sarcomas: estimation of necrotic fraction during induction chemotherapy with dynamic contrast-enhanced MR imaging. Radiology, 228 (1). pp. 271-278. ISSN 0033-8419 (Print)

Davies, G. R., Ramani, A., Dalton, C. M., Tozer, D. J., Wheeler-Kingshott, C. A., Barker, G. J., Thompson, A. J., Miller, D. H. and Tofts, P. S. (2003) Preliminary magnetic resonance study of the macromolecular proton fraction in white matter: a potential marker of myelin? Multiple Sclerosis, 9 (3). pp. 246-249. ISSN 1352-4585

Tozer, D., Ramani, A., Barker, G. J., Davies, G. R., Miller, D. H. and Tofts, P. S. (2003) Quantitative magnetization transfer mapping of bound protons in multiple sclerosis. Magnetic Resonance in Medicine, 50 (1). pp. 83-91. ISSN 0740-3194

Tozer, D. J. and Tofts, P. S. (2003) Removing spikes caused by quantization noise from high-resolution histograms. Magnetic Resonance in Medicine, 50 (3). pp. 649-653. ISSN 0740-3194

Dehmeshki, J., Chard, D. T., Leary, S. M., Watt, H. C., Silver, N. C., Tofts, P. S., Thompson, A. J. and Miller, D. H. (2003) The normal appearing grey matter in primary progressive multiple sclerosis: a magnetisation transfer imaging study. Journal of Neurology, 250 (1). pp. 67-74. ISSN 0340-5354

Dehmeshki, J., Barker, G.J. and Tofts, Paul Stephen (2002) Classification of disease subgroup and correlation with disease severity using magnetic resonance imaging whole-brain histograms: application to magnetization transfer ratios and multiple sclerosis. IEEE Transactions on Medical Imaging, 21 (4). pp. 320-331. ISSN 0278-0062

Parkes, L. M. and Tofts, P. S. (2002) Improved accuracy of human cerebral blood perfusion measurements using arterial spin labeling: accounting for capillary water permeability. Magnetic Resonance in Medicine, 48 (1). pp. 27-41. ISSN 0740-3194

Dehmeshki, J., Van Buchem, M. A., Bosma, G. P., Huizinga, T. W. and Tofts, P. S. (2002) Systemic lupus erythematosus: diagnostic application of magnetization transfer ratio histograms in patients with neuropsychiatric symptoms - initial results. Radiology, 222 (3). pp. 722-728. ISSN 0033-8419 (Print)

Parker, G. J., Barker, G. J. and Tofts, P. S. (2001) Accurate multislice gradient echo T(1) measurement in the presence of non-ideal RF pulse shape and RF field nonuniformity. Magnetic Resonance in Medicine, 45 (5). pp. 838-845. ISSN 0740-3194

Dehmeshki, J., Silver, N. C., Leary, S. M., Tofts, P. S., Thompson, A. J. and Miller, D. H. (2001) Magnetisation transfer ratio histogram analysis of primary progressive and other multiple sclerosis subgroups. Journal of the Neurological Sciences, 185 (1). pp. 11-17. ISSN 0022-510X

Berkowitz, B. A., McDonald, C., Ito, Y., Tofts, P. S., Latif, Z. and Gross, J. (2001) Measuring the human retinal oxygenation response to a hyperoxic challenge using MRI: eliminating blinking artifacts and demonstrating proof of concept. Magnetic Resonance in Medicine, 46 (2). pp. 412-416. ISSN 0740-3194

Lepage, M., Tofts, P. S., Back, S. A., Jayasekera, P. M. and Baldock, C. (2001) Simple methods for the correction of T2 maps of phantoms. Magnetic Resonance in Medicine, 46 (6). pp. 1123-1129. ISSN 0740-3194

Clark, Chris A., Barker, Gareth J. and Tofts, Paul S. (2000) Improved reduction of motion artifacts in diffusion imaging using navigator echoes and velocity compensation. Journal of Magnetic Resonance, 142 (2). pp. 358-363. ISSN 1090-7807

van Buchem, M. A. and Tofts, P. S. (2000) Magnetization transfer imaging. Neuroimaging Clinics of North America, 10 (4). pp. 771-788. ISSN 1052-5149

Tofts, P. S., Lloyd, D., Clark, C. A., Barker, G. J., Parker, G. J., McConville, P., Baldock, C. and Pope, J. M. (2000) Test liquids for quantitative MRI measurements of self-diffusion coefficient in vivo. Magnetic Resonance in Medicine, 43 (3). pp. 368-374. ISSN 0740-3194

Grimaud, J., Barker, G. J., Wang, L., Lai, M., MacManus, D. G., Webb, S. L., Thompson, A. J., McDonald, W. I., Tofts, P. S. and Miller, D. H. (1999) Correlation of magnetic resonance imaging parameters with clinical disability in multiple sclerosis: a preliminary study. Journal of Neurology, 246 (10). pp. 961-967. ISSN 0340-5354

Tofts, Paul S., Brix, Gunnar, Buckley, David L., Evelhoch, Jeffrey L., Henderson, Elizabeth, Knopp, Michael V., Larsson, Henrik B., Lee, Ting-Yim, Mayr, Nina A., Parker, Geoffrey J., Port, Ruediger E., Taylor, June and Weisskoff, Robert M. (1999) Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols. Journal of Magnetic Resonance Imaging, 10 (3). pp. 223-232. ISSN 1053-1807

Taylor, June S., Tofts, Paul S., Port, Ruediger, Evelhoch, Jeffrey L., Knopp, Michael, Reddick, Wilburn E., Runge, Val M. and Mayr, Nina (1999) MR imaging of tumor microcirculation: promise for the new millennium. Journal of Magnetic Resonance Imaging, 10 (6). pp. 903-907. ISSN 1053-1807

Clark, C. A., Barker, G. J. and Tofts, P. S. (1999) Magnetic resonance diffusion imaging of the human cervical spinal cord in vivo. Magnetic Resonance in Medicine, 41 (6). pp. 1269-1273. ISSN 0740-3194

Mathias, J. M., Tofts, P. S. and Losseff, N. A. (1999) Texture analysis of spinal cord pathology in multiple sclerosis. Magnetic Resonance in Medicine, 42 (5). pp. 929-935. ISSN 0740-3194

Clark, C. A., Barker, G. J. and Tofts, P. S. (1999) An in vivo evaluation of the effects of local magnetic susceptibility-induced gradients on water diffusion measurements in human brain. Journal of Magnetic Resonance, 141 (1). pp. 52-61. ISSN 1090-7807

Berry, Isabelle, Barker, Gareth J., Barkhof, Frederik, Campi, Adriana, Dousset, Vincent, Franconi, Jean-Michel, Gass, Achim, Schreiber, Wolfgang, Miller, David H. and Tofts, Paul S. (1999) A multicenter measurement of magnetization transfer ratio in normal white matter. Journal of Magnetic Resonance Imaging, 9 (3). pp. 441-446. ISSN 1053-1807

Simmons, A., Arridge, S. R., Tofts, P. S. and Barker, G. J. (1998) Application of the extremum stack to neurological MRI. IEEE Transactions on Medical Imaging, 17 (3). pp. 371-382. ISSN 0278-0062

Filippi, M., Horsfield, M. A., Ader, H. J., Barkhof, F., Bruzzi, P., Evans, A., Frank, J. A., Grossman, R. I., McFarland, H. F., Molyneux, P., Paty, D. W., Simon, J., Tofts, P. S., Wolinsky, J. S. and Miller, D. H. (1998) Guidelines for using quantitative measures of brain magnetic resonance imaging abnormalities in monitoring the treatment of multiple sclerosis. Annals of Neurology, 43 (4). pp. 499-506. ISSN 0364-5134

Molyneux, P. D., Tofts, P. S., Fletcher, A., Gunn, B., Robinson, P., Gallagher, H., Moseley, I. F., Barker, G. J. and Miller, D. H. (1998) Precision and reliability for measurement of change in MRI lesion volume in multiple sclerosis: a comparison of two computer assisted techniques. Journal of Neurology, Neurosurgery and Psychiatry, 65 (1). pp. 42-47. ISSN 0022-3050

Tofts, P. S. (1998) Standardisation and optimisation of magnetic resonance techniques for multicentre studies. Journal of Neurology, Neurosurgery and Psychiatry, 64 Sup. S37-543. ISSN 0022-3050

Barker, G. J., Simmons, A., Arridge, S. R. and Tofts, P. S. (1998) A simple method for investigating the effects of non-uniformity of radiofrequency transmission and radiofrequency reception in MRI. British Journal of Radiology, 71 (841). pp. 59-67. ISSN 0007-1285

Tofts, Paul S. (1997) Modeling tracer kinetics in dynamic Gd-DTPA MR imaging. Journal of Magnetic Resonance Imaging, 7 (1). pp. 91-101. ISSN 1053-1807

Tofts, P. S., Barker, G. J., Dean, T. L., Gallagher, H., Gregory, A. P. and Clarke, R. N. (1997) A low dielectric constant customized phantom design to measure RF coil nonuniformity. Magnetic Resonance Imaging, 15 (1). pp. 69-75. ISSN 0730-725X

Tofts, P. S., Barker, G. J., Filippi, M., Gawne-Cain, M. and Lai, M. (1997) An oblique cylinder contrast-adjusted (OCCA) phantom to measure the accuracy of MRI brain lesion volume estimation schemes in multiple sclerosis. Magnetic Resonance Imaging, 15 (2). pp. 183-192. ISSN 0730-725X

Kidd, D., Barker, G. J., Tofts, P. S., Gass, A., Thompson, A. J., McDonald, W. I. and Miller, D. H. (1997) The transverse magnetisation decay characteristics of longstanding lesions and normal-appearing white matter in multiple sclerosis. Journal of Neurology, 244 (2). pp. 125-30. ISSN 0340-5354

Book Section

Dowell, Nicholas G. and Tofts, Paul S. (2011) Quality Assurance for Diffusion MRI. In: Jones, Derek K. (ed.) Diffusion MRI: Theory, Methods, and Applications. Oxford University Press Inc.. ISBN 9780195369779