Selected publications

Article

Pienaar, Ilse S, Mohammed, Rean, Courtley, Rebecca, Gledson, Michael R, Reynolds, Richard, Nicholas, Richard and Elson, Joanna L (2021) Investigation of the correlation between mildly deleterious mtDNA variations and the clinical progression of multiple sclerosis. Multiple Sclerosis and Related Disorders, 53. a103055. ISSN 2211-0348

Bailey, Laura J, Elson, Joanna L and Pienaar, Ilse S (2021) Single-cell approaches for studying the role of mitochondrial DNA in neurodegenerative disease. Methods in Molecular Biology, 2277. pp. 299-329. ISSN 1064-3745

Mantanona, Craig P, Božič, Tadej, Chudasama, Yogita, Robbins, Trevor W, Dalley, Jeffrey W, Alsiö, Johan and Pienaar, Ilse S (2020) Dissociable contributions of mediodorsal and anterior thalamic nuclei in visual attentional performance: a comparison using nicotinic and muscarinic cholinergic receptor antagonists. Journal of Psychopharmacology. pp. 1-11. ISSN 0269-8811

Gutbier, Simon, Kyriakou, Sotiris, Schildknecht, Stefan, Ückert, Anna-Katharina, Brüll, Markus, Lewis, Frank, Dickens, David, Pearson, Liam, Elson, Joanna L, Michel, Sylvia, Hubscher-Bruder, Véronique, Brandel, Jeremy, Tetard, David, Leist, Marcel and Pienaar, Ilse S (2020) Design and evaluation of bi-functional iron chelators for protection of dopaminergic neurons from toxicants. Archives of Toxicology. ISSN 0340-5761

Lewis, Frank W, Fairooz, Safiya, Elson, Joanna L, Hubscher-Bruder, Véronique, Brandel, Jeremy, Soundararajan, Meera, Smith, David, Dexter, David T, Tétard, David and Pienaar, Ilse S (2020) Novel 1-hydroxypyridin-2-one metal chelators prevent and res-cue ubiquitin proteasomal-related neuronal injury in an in vitro model of Parkinson’s disease. Archives of Toxicology. pp. 1-19. ISSN 0340-5761

Sharma, Puneet K, Wells, Lisa, Rizzo, Gaia, Elson, Joanna L, Passchier, Jan, Rabiner, Eugenii A, Gunn, Roger N, Dexter, David T and Pienaar, Ilse S (2020) DREADD activation of pedunculopontine cholinergic neurons reverses motor deficits and restores striatal dopamine signaling in parkinsonian rats. Neurotherapeutics. ISSN 1933-7213

Thubron, Elisabeth B, Rosa, Hannah S, Hodges, Angela, Sivaprasad, Sobha, Francis, Paul T, Pienaar, Ilse S and Malik, Afshan N (2019) Regional mitochondrial DNA and cell-type changes in post-mortem brains of non-diabetic Alzheimer’s disease are not present in diabetic Alzheimer’s disease. Scientific Reports, 9 (1). a11386. ISSN 2045-2322

Mantanona, Craig P, Alsiö, Johan, Elson, Joanna L, Fisher, Beth M, Dalley, Jeffrey W, Bussey, Timothy and Pienaar, Ilse S (2019) Altered motor, anxiety-related and attentional task performance at baseline associate with multiple gene copies of the vesicular acetylcholine transporter and related protein overexpression in ChAT::Cre+ rats. Brain Structure and Function. pp. 3095-3116. ISSN 1863-2661

Müller-Nedebock, Amica C, Brennan, Rebecca R, Venter, Marianne, Pienaar, Ilse, van der Westhuizen, Francois H, Elson, Joanna L, Ross, Owen A and Bardien, Soraya (2019) The unresolved role of mitochondrial DNA in Parkinson’s disease: an overview of published studies, their limitations, and future prospects. Neurochemistry International. ISSN 0197-0186

Venter, Marianne, Tomas, Cara, Pienaar, Ilse S, Strassheim, Victoria, Erasmus, Elardus, Ng, Wan-Fai, Howell, Neil, Newton, Julia L, van der Westhuizen, Francois H and Elson, Joanna L (2019) MtDNA population variation in Myalgic encephalomyelitis/Chronic fatigue syndrome in two populations: a study of mildly deleterious variants. Scientific Reports, 9 (2914). pp. 1-8. ISSN 2045-2322

Kay, Laura, Pienaar, Ilse S, Cooray, Ruwini and Soundararajan, Meera (2018) Understanding miro GTPases: implications in the treatment of neurodegenerative disorders. Molecular Neurobiology, 55 (9). pp. 7352-7365. ISSN 0893-7648

Elson, Joanna L, Kochaj, Rafael, Reynolds, Richard and Pienaar, Ilse S (2018) Temporal-spatial profiling of pedunculopontine galanin-cholinergic neurons in the lactacystin rat model of Parkinson’s disease. Neurotoxicity Research, 34 (1). pp. 16-31. ISSN 1029-8428

Bury, Alexander G, Pyle, Angela, Elson, Joanna L, Greaves, Laura, Morris, Christopher M, Hudson, Gavin and Pienaar, Ilse (2017) Mitochondrial DNA changes in pedunculopontine cholinergic neurons in Parkinson’s disease. Annals of Neurology, 82 (6). pp. 1016-1021. ISSN 0364-5134

Pienaar, Ilse, Vernon, Anthony and Winn, Philip (2017) The cellular diversity of the pedunculopontine nucleus: relevance to behavior in health and aspects of Parkinson's disease. Neuroscientist, 23 (4). pp. 415-431. ISSN 1073-8584

Pienaar, Ilse S, Howell, Neil and Elson, Joanna L (2017) MutPred mutational load analysis shows mildly deleterious mitochondrial DNA variants are not more prevalent in Alzheimer's patients, but may be under-represented in healthy older individuals. Mitochondrion, 34. pp. 141-146. ISSN 1567-7249

Gillies, Glenda E, Virdee, Kanwar, Pienaar, Ilse, Al-Zaid, Felwah and Dalley, Jeffey W (2016) Enduring, sexually dimorphic impact of in utero exposure to elevated levels of glucocorticoids on midbrain dopaminergic populations. Brain Sciences, 7 (5). pp. 1-29. ISSN 2076-3425

Elson, Joanna L, Yates, Abi and Pienaar, Ilse S (2016) Pedunculopontine cell loss and protein aggregation direct microglia activation in parkinsonian rats. Brain Structure and Function, 221 (4). pp. 2319-2341. ISSN 1863-2653

Pienaar, Ilse S, Gartside, Sarah E, Sharma, Puneet, De Paola, Vincenzo, Gretenkord, Sabine, Withers, Dominic, Elson, Joanna L and Dexter, David T (2015) Pharmacogenetic stimulation of cholinergic pedunculopontine neurons reverses motor deficits in a rat model of Parkinson’s disease. Molecular Neurodegeneration, 10 (1). a47 1-22. ISSN 1750-1326

Goode, Angela E, Gonzalez Carter, Daniel A, Motskin, Michael, Pienaar, Ilse, Chen, Shu, Hu, Sheng, Ruenraroengsak, Pakatip, Ryan, Mary P, Shaffer, Milo S P, Dexter, David T and Porter, Alexandra E (2015) High resolution and dynamic imaging of biopersistence and bioreactivity of extra and intracellular MWNTs exposed to microglial cells. Biomaterials, 70. pp. 57-70. ISSN 0142-9612

Pienaar, Ilse S, Lee, Cecilia H, Elson, Joanna L, McGuinness, Louisa, Gentleman, Stephen M, Kalaria, Raj N and Dexter, David T (2015) Deep-brain stimulation associates with improved microvascular integrity in the subthalamic nucleus in Parkinson's disease. Neurobiology of Disease, 74. pp. 392-405. ISSN 0969-9961

Proctor, Carole J, Pienaar, Ilse Sanet, Elson, Joanna L and Kirkwood, Thomas B L (2012) Aggregation, impaired degradation and immunization targeting of amyloid-beta dimers in Alzheimer’s disease: a stochastic modelling approach. Molecular Neurodegeneration, 7. a32 1-17. ISSN 1750-1326

Book Section

Sharma, Puneet and Pienaar, Ilse (2018) The use of DREADDs for dissecting the contribution of cellular and neural circuit mechanisms in models of neurodegenerative disease. In: Gerlai, Robert (ed.) Molecular-genetic and statistical techniques for behavioral and neural research. Academic Press, New York. ISBN 9780128040782