Photo of John AtackJohn Atack
Professor Of Molecular Pharmacology (Dementia Research Group)

Selected publications

Article

Raulin, Ana-Caroline, Kraft, Lucas, Al-Hilaly, Youssra, Xue, Wei-Feng, McGeehan, John E, Atack, John R and Serpell, Louise (2019) The molecular basis for apolipoprotein E4 as the major risk factor for late onset Alzheimer's disease. Journal of Molecular Biology, 431 (12). pp. 2248-2265. ISSN 0022-2836

Noble, James William, Almalki, Rehab, Roe, Mark, Duman, Ramona, Wagner, Armin and Atack, John (2018) The X-ray structure of human calbindin-D28K: an improved model. Acta Crystallographica Section D: Structural Biology, 74 (10). pp. 1008-1014. ISSN 2059-7983

Kraft, L, Roe, M, Gill, R and Atack, J R (2018) Co‐crystallization of human inositol monophosphatase with the lithium mimetic L‐690,330. Acta Crystallographica Section D: Structural Biology, 74. pp. 973-978. ISSN 0907-4449

West, Ryan A, O'Doherty, Oran G, Askwith, Trevor, Atack, John, Beswick, Paul, Laverick, Jamie, Paradowski, Michael, Pennicott, Lewis E, Rao, Srinivasa P S, Williams, Gareth and Ward, Simon E (2017) African trypanosomiasis: Synthesis & SAR enabling novel drug discovery of ubiquinol mimics for trypanosome alternative oxidase. European Journal of Medicinal Chemistry, 141. pp. 676-689. ISSN 0223-5234

Khan, Raysa, Boonseng, Sarote, Kemmitt, Paul, Felix, Robert, Coles, Simon J, Tizzard, Graham J, Williams, Gareth, Simmonds, Olivia, Harvey, Jessica-Lily, Atack, John, Cox, Hazel and Spencer, John (2017) Combining Sanford arylations on benzodiazepines with the nuisance effect. Advanced Synthesis and Catalysis, 359 (18). pp. 3261-3269. ISSN 1615-4150

Hornyak, Peter, Askwith, Trevor, Walker, Sarah, Komulainen, Emilia, Paradowski, Michael, Pennicott, Lewis E, Bartlett, Edward J, Brissett, Nigel C, Raoof, Ali, Watson, Mandy, Jordan, Allan M, Ogilvie, Donald J, Ward, Simon E, Atack, John R, Pearl, Laurence H, Caldecott, Keith W and Oliver, Antony W (2016) Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2. Biochemical Journal, 473 (13). pp. 1869-1879. ISSN 0264-6021

Walker, Sarah, Meisenberg, Cornelia, Bibby, Rachel A, Askwith, Trevor, Williams, Gareth, Rininsland, Frauke H, Pearl, Laurence H, Oliver, Antony W, El-Khamisy, Sherif, Ward, Simon and Atack, John R (2014) Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors. Analytical Biochemistry, 454. pp. 17-22. ISSN 0003-2697

Shinday, Nina M, Sawyer, Eileen K, Fischer, Bradford D, Platt, Donna M, Licata, Stephanie C, Atack, John R, Dawson, Gerard R, Reynolds, David S and Rowlett, James K (2013) Reinforcing effects of compounds lacking intrinsic efficacy at α1 subunit-containing GABAA receptor subtypes in midazolam- but not cocaine-experienced rhesus monkeys. Neuropsychopharmacology, 38 (6). pp. 1006-1014. ISSN 0893-133X

Eng, W, Atack, J, Bergstrom, M, Sanabria, S, Appel, L, Dawson, G R, Sciberras, G, Hargreaves, R J, Langstrom, B and Burns, H D (2010) Occupancy of human brain GABA A receptors by the novel α5 subtype-selective benzodiazepine site inverse agonist α5IA as measured using [ 11C]flumazenil PET imaging. Neuropharmacology, 59 (7). pp. 635-639. ISSN 0028-3908

Dixon, Claire I, Morris, Hannah V, Breen, Gerome, Desrivieres, Sylvane, Jugurnauth, Sarah, Steiner, Rebecca C, Vallada, Homero, Guindalini, Camila, Laranjeira, Ronaldo, Messas, Guilherme, Rosahl, Thomas W, Atack, John R, Peden, Dianne R, Belelli, Delia, Lambert, Jeremy J, King, Sarah L, Schumann, Gunter and Stephens, David N (2010) Cocaine effects on mouse incentive-learning and human addiction are linked to α2 subunit-containing GABAA receptors. Proceedings of the National Academy of Sciences, 107 (5). pp. 2289-2294. ISSN 0027-8424

Atack, John R, Wong, Dean F, Fryer, Tim D, Ryan, Christine, Sanabria, Sandra, Zhou, Yun, Dannals, Robert F, Eng, Wai-si, Gibson, Raymond E, Burns, H Donald, Vega, Jose M, Vessy, Laura, Scott-Stevens, Paul, Beech, John S, Baron, Jean-Claude, Sohal, Bindi, Schrag, Michael L, Aigbirhio, Franklin I, McKernan, Ruth M and Hargreaves, Richard J (2010) Benzodiazepine binding site occupancy by the novel GABAA receptor subtype-selective drug 7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in rats, primates, and humans. The Journal of Pharmacology and Experimental Therapeutics, 332 (1). pp. 17-25. ISSN 0022-3565

Atack, John R (2010) Preclinical and clinical pharmacology of the GABAA receptor α5 subtype-selective inverse agonist α5IA. Pharmacology and Therapeutics, 125 (1). pp. 11-26. ISSN 0163-7258

Atack, John R, Maubach, Karen A, Wafford, Keith A, O'Connor, Desmond, Rodrigues, A David, Evans, David C, Tattersall, F David, Chambers, Mark S, MacLeod, Angus M, Eng, Wai-Si, Ryan, Christine, Hostetler, Eric, Sanabria, Sandra M, Gibson, Raymond E, Krause, Stephen, Burns, H Donald, Hargreaves, Richard J, Agrawal, Nancy G B, McKernan, Ruth M, Murphy, M Gail, Gingrich, Kevin, Dawson, Gerard R, Musson, Donald G and Petty, Kevin J (2009) In vitro and in vivo properties of 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA receptor alpha5 subtype-selective inverse agonist. Journal of Pharmacology and Experimental Therapeutics, 331 (2). pp. 470-484. ISSN 0022-3565

Atack, John R, Eng, Wai-Si, Gibson, Ray E, Ryan, Christine, Francis, Barbara, Sohal, Bindi, Dawson, Gerard R, Hargreaves, Richard J and Burns, H Donald (2009) The plasma-occupancy relationship of the novel GABAA receptor benzodiazepine site ligand, alpha5IA, is similar in rats and primates. British Journal of Pharmacology, 157 (5). pp. 796-803. ISSN 1476-5381

Van Laere, Koen, Bormans, Guy, Sanabria-Bohórquez, Sandra M, de Groot, Tjibbe, Dupont, Patrick, De Lepeleire, Inge, de Hoon, Jan, Mortelmans, Luc, Hargreaves, Richard J, Atack, John R and Burns, H Donald (2008) In vivo characterization and dynamic receptor occupancy imaging of TPA023B, an alpha 2/alpha 3/alpha 5 subtype selective gamma-aminobutyric acid-a partial agonist. Biological Psychiatry, 64 (2). pp. 153-161. ISSN 0006-3223

Stephens, David N, Pistovkacova, Jana, Worthing, Lynn, Atack, John R and Dawson, Gerard R (2005) Role of GABAA α5-containing receptors in ethanol reward in the mouse: the effects of targeted gene deletion and a selective inverse agonist. European Journal of Pharmacology, 526 (1-3). pp. 240-250. ISSN 0014-2999