Felicity WattsEmeritus Professor/Reader (Genome Damage and Stability)
Selected publications
Article
Bigot, Nicolas, Day, Matthew, Baldock, Robbie A, Watts, Felicity Z, Oliver, Antony W and Pearl, Laurence H (2019) Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint. eLIfe, 8. a44353 1-28. ISSN 2050-084X
Lu, Wei-Ting, Hawley, Ben R, Skalka, George L, Baldock, Robert A, Smith, Ewan M, Bader, Aldo S, Malewicz, M, Watts, Felicity Z, Wilczynska, Ania and Bushell, Martin (2018) Drosha drives the formation of DNA:RNA hybrids around DNA break sites to facilitate DNA repair. Nature Communications, 9 (532). pp. 1-13. ISSN 2041-1723
Watts, Felicity Z (2016) Repair of DNA double-strand breaks in heterochromatin. Biomolecules, 6 (4). p. 47. ISSN 2218-273X
Jongjitwimol, Jirapas, Baldock, Robert A, Morley, Simon J and Watts, Felicity Z (2016) Sumoylation of eIF4A2 affects stress granule formation. Journal of Cell Science, 129 (12). pp. 2407-2415. ISSN 0021-9533
Densham, Ruth M, Garvin, Alexander J, Stone, Helen R, Strachan, Joanna, Baldock, Robert A, Daza-Martin, Manuel, Fletcher, Alice, Blair-Reed, Sarah, Beesley, James, Johal, Balraj, Pearl, Laurence H, Neely, Robert, Keep, Nicholas H, Watts, Felicity Z and Morris, Joanna R (2016) Human BRCA1-BARD1 ubiquitin ligase activity counters chromatin barriers to DNA resection. Nature Structural and Molecular Biology, 23 (7). pp. 647-655. ISSN 1545-9993
Baldock, Robert A, Day, Matthew, Wilkinson, Oliver J, Cloney, Ross, Jeggo, Penelope A, Oliver, Antony W, Watts, Felicity Z and Pearl, Laurence H (2015) ATM localization and heterochromatin repair depend on Direct Interaction of the 53BP1-BRCT2 domain with γH2AX. Cell Reports, 13 (10). pp. 2081-2089. ISSN 2211-1247
Watts, Felicity Z, Baldock, Robert, Jongjitwimol, Jirapas and Morley, Simon J (2014) Weighing up the possibilities: controlling translation by ubiquitylation and sumoylation. Translation, 2 (2). e959366-1. ISSN 2169-074X
Garg, Mansi, Gurung, Resham L, Mansoubi, Sahar, Ahmed, Jubed O, Davé, Anoushka, Watts, Felicity Z and Bianchi, Alessandro (2014) Tpz1TPP1 SUMOylation reveals evolutionary conservation of SUMO-dependent Stn1 telomere association. EMBO Reports, 15 (8). pp. 871-877. ISSN 1469-3178
Jongjitwimol, Jirapas, Feng, Min, Zhou, Lihong, Wilkinson, Oliver, Small, Lauren, Baldock, Robert, Taylor, Deborah L, Smith, Duncan, Bowler, Lucas, Morley, Simon J and Watts, Felicity (2014) The S. pombe translation initiation factor eIF4G is sumoylated and associates with the SUMO protease Ulp2. PLoS ONE, 9 (5). e94182. ISSN 1932-6203
Watts, Felicity Z (2013) Starting and stopping SUMOylation. What regulates the regulator? Chromosoma, 122 (6). pp. 451-463. ISSN 0009-5915
Watts, Felicity Z and Hoffmann, Eva (2011) SUMO meets meiosis: an encounter at the synaptonemal complex: SUMO chains and sumoylated proteins suggest that heterogeneous and complex interactions lie at the centre of the synaptonemal complex. BioEssays, 33. pp. 529-33. ISSN 0265-9247
Boyd, Lara K, Mercer, Brenda, Thompson, Darren, Main, Ewan and Watts, Felicity W (2010) Characterisation of the SUMO-like domains of Schizosaccharomyces pombe Rad60. PLoS ONE, 5 (9). pp. 1-11. ISSN 1932-6203
Watts, Felicity Z and Brissett, Nigel C (2010) Linking up and interacting with BRCT domains. DNA Repair, 9 (2). pp. 103-8. ISSN 1568-7864
Spirek, Mario, Estreicher, Anna, Csaszar, Edina, Wells, Jennifer, McFarlane, Ramsay J, Watts, Felicity Z and Loidl, Josef (2010) Sumoylation is required for normal development of linear element and wild-type meiotic recombination in Schizosaccharomyces pombe. Chromosoma, 9 (11). pp. 59-72. ISSN 0009-5915
Spirek, M, Estredicher, A, Csaszar, E, Wells, J, McFarlane, Ramsay J, Watts, Felicity and Loidl, J (2010) SUMOylation is required for normal development of linear elements and wild-type meiotic recombination in Schizosaccharomyces pombe. Chromosoma, 119 (1). pp. 59-72. ISSN 1432-0886 (Electronic)
Skilton, Andrew, Outwin, Emily, Mercer, Brenda, Ho, J C Y and Watts, Felicity (2009) SUMO chain formation is required for response to replication arrest in S. pombe. PLoS ONE, 4 (8). e6750. ISSN 1932-6203
Kilkenny, Mairi L, Doré, Andrew S, Roe, S Mark, Nestoras, Konstantinos, Ho, Jenny C Y, Watts, Felicity Z and Pearl, Laurence H (2008) Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signalling. Genes & Development, 22 (15). pp. 2034-47. ISSN 0890-9369
Kilkenney, M L, Dore, A, Roe, S M, Nestoras, K, Ho, J, Watts, F Z and Pearl, L (2008) Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair. Genes & Development, 22 (15). pp. 2034-2047. ISSN 0890-9369
Watts, Felicity, Skilton, Andrew, Ho, J C, Boyd, Lara Katrina, Trickey, M A, Gardner, Lisa and Ogi, Francois-Xavier (2007) The role of Schizosaccharomyces pombe SUMO ligases in genome stability. Biochemical Society Transactions, 35 (6). pp. 1379-1384. ISSN 0300-5127
Watts, Felicity (2007) The role of SUMO in chromosome segregation. Chromosoma, 116 (1). pp. 15-20. ISSN 1432-0886
Frampton, Jonathan, Irmisch, Anja, Green, Catherine M, Neiss, Andrea, Trickey, Michelle, Ulrich, Helle D, Furuya, Kanji, Watts, Felicity, Carr, Antony M and Lehmann, Alan R (2006) Postreplication Repair and PCNA Modification in Schizosaccharomyces pombe. Molecular Biology of the Cell, 17 (7). pp. 2976-2985. ISSN 1059-1524
Watts, Felicity (2006) Sumoylation of PCNA: Wrestling with recombination at stalled replication forks. DNA Repair, 5 (3). pp. 399-403. ISSN 1568-7864
Shin, Jin, Choi, Eun Shik, Kim, Hyun Soo, Ho, J C, Watts, Felicity Z, Park, Sang D and Jang, Yeun Kyu (2005) SUMO modification is involved in the maintenance of heterochromatin stability in fission yeast. Molecular Cell, 19 (6). pp. 817-828. ISSN 1097-2765
Sergeant, John, Taylor, Elaine, Palecek, Jan, Fousteri, Maria, Andrews, Emily, Sweeney, Sara, Shinagawa, Hideo, Watts, Felicity and Lehmann, Alan (2005) Composition and Architecture of the Schizosaccharomyces pombe Rad18 (Smc5-6) Complex. Molecular and Cellular Biology, 25 (1). pp. 172-184. ISSN 0270-7306
Andrews, Emily A, Palecek, Jan, Sergeant, John, Taylor, Elaine, Lehmann, Alan R and Watts, Felicity Z (2005) Nse2, a component of the Smc5-6 complex, is a SUMO ligase required for the response to DNA damage. Molecular and Cellular Biology, 25 (1). pp. 185-196. ISSN 0270-7306
Zhou, Lihong and Watts, Felicity (2005) Nep1, a Schizosaccharomyces pombe deneddylating enzyme. Biochemical Journal, 389 (Pt 2). pp. 307-314. ISSN 0264-6021
Spink, K, Ho, J C, Tanaka, K, Watts, Felicity and Chambers, Anna (2005) The telomere-binding protein Taz1p as a target for modification by a SUMO-1 homologue in fission yeast. Biochemical Genetics, 43 (3-4). pp. 103-17. ISSN 0006-2928
Watts, Felicity (2004) SUMO modification of proteins other than transcription factors. Seminars in Cell & Developmental Biology, 15 (2). pp. 211-220. ISSN 10849521
Ho, J C and Watts, Felicity (2003) Characterisation of SUMO conjugating enzyme mutants in Schizosaccharomyces pombe identifies a dominant negative allele which severely reduces SUMO conjugation. Biochemical Journal, 21. ISSN 0264-6021
Hinks, J, Roe, Mark, Ho, J C, Watts, Felicity, Phelan, J, McAllister, M and Pearl, Laurence (2003) Expression, purification and preliminary X-ray analysis of the BRCT domain from Rhp9/Crb2. Acta Crystallographica Section D: Biological Crystallography, 59 (Pt 7). 1230-1233.. ISSN 0907-4449
Taylor, Deborah, Ho, Jenny, Oliver, Alejandro and Watts, Felicity (2002) Cell-cycle-dependent localisation of Ulp1, a Schizosaccharomyces pombe Pmt3 (SUMO)-specific protease. Journal of Cell Science, 115 (6). pp. 1113-1122. ISSN 0021-9533
Ho, J C, Warr, N J, Shimizu, H and Watts, Felicity (2001) SUMO modification of Rad22, the Schizosaccharomyces pombe homologue of the recombination protein Rad52. Nucleic Acids Research, 29 (20). pp. 4179-4186. ISSN 1362-4962