Simon WardSelected publications
Article
O'Reilly, Molly, Kirkwood, Nerissa K, Kenyon, Emma J, Huckvale, Rosemary, Cantillon, Daire M, Waddell, Simon J, Ward, Simon E, Richardson, Guy P, Kros, Corné J and Derudas, Marco (2019) Design, synthesis and biological evaluation of a new series of carvedilol derivatives that protect sensory hair cells from aminoglycoside-induced damage by blocking the mechanoelectrical transducer channel. Journal of Medicinal Chemistry, 62 (11). pp. 5312-5329. ISSN 0022-2623
West, Ryan, Cunningham, Thomas, Pennicott, Lewis, Rao, Srinivasa and Ward, Simon (2018) Toward more drug like inhibitors of trypanosome alternative oxidase. ACS Infectious Diseases, 4 (4). pp. 592-604. ISSN 2373-8227
Kenyon, Emma J, Kirkwood, Nerissa K, Kitcher, Siân R, O'Reilly, Molly, Derudas, Marco, Cantillon, Daire M, Goodyear, Richard J, Secker, Abigail, Baxendale, Sarah, Bulley, James C, Waddell, Simon J, Whitfield, Tanya T, Ward, Simon E, Kros, Corné J and Richardson, Guy P (2017) Identification of ion-channel modulators that protect against aminoglycoside-induced hair cell death. Journal of Clinical Investigation Insight, 2 (24). a96773 1-16. ISSN 2379-3708
West, Ryan A, O'Doherty, Oran G, Askwith, Trevor, Atack, John, Beswick, Paul, Laverick, Jamie, Paradowski, Michael, Pennicott, Lewis E, Rao, Srinivasa P S, Williams, Gareth and Ward, Simon E (2017) African trypanosomiasis: Synthesis & SAR enabling novel drug discovery of ubiquinol mimics for trypanosome alternative oxidase. European Journal of Medicinal Chemistry, 141. pp. 676-689. ISSN 0223-5234
Kirkwood, Nerissa K, O'Reilly, Molly, Derudas, Marco, Kenyon, Emma J, Huckvale, Rosemary, van Netten, Sietse M, Ward, Simon E, Richardson, Guy P and Kros, Corné Kros (2017) d-Tubocurarine and berbamine: alkaloids that are permeant blockers of the hair cell's mechano-electrical transducer channel and protect from aminoglycoside toxicity. Frontiers in Cellular Neuroscience, 11. ISSN 1662-5102
Ocasio, Cory A, Rajasekaran, Mohan B, Walker, Sarah, Le Grand, Darren, Spencer, John, Pearl, Frances M G, Ward, Simon E, Savic, Velibor, Pearl, Laurence H, Hochegger, Helfrid and Oliver, Antony W (2016) A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct. Oncotarget, 7 (44). 71182 -71197. ISSN 1949-2553
Reuillon, Tristan, Ward, Simon and Beswick, Paul (2016) AMPA receptor positive allosteric modulators: potential for the treatment of neuropsychiatric and neurological disorders. Current Topics in Medicinal Chemistry, 16 (29). pp. 3536-3565. ISSN 1568-0266
Hornyak, Peter, Askwith, Trevor, Walker, Sarah, Komulainen, Emilia, Paradowski, Michael, Pennicott, Lewis E, Bartlett, Edward J, Brissett, Nigel C, Raoof, Ali, Watson, Mandy, Jordan, Allan M, Ogilvie, Donald J, Ward, Simon E, Atack, John R, Pearl, Laurence H, Caldecott, Keith W and Oliver, Antony W (2016) Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2. Biochemical Journal, 473 (13). pp. 1869-1879. ISSN 0264-6021
Pearl, Laurence H, Schierz, Amanda C, Ward, Simon E, Al-Lazikani, Bissan and Pearl, Frances M G (2015) Therapeutic opportunities within the DNA damage response. Nature Reviews Cancer, 15 (3). pp. 166-180. ISSN 1474-175X
Ward, Simon E, Pennicott, Lewis E and Beswick, Paul (2015) AMPA receptor-positive allosteric modulators for the treatment of schizophrenia: an overview of recent patent applications. Future Medicinal Chemistry, 7 (4). pp. 473-491. ISSN 1756-8919
Ward, Simon E and Beswick, Paul (2014) What does the aromatic ring number mean for drug design? Expert Opinion on Drug Discovery, 9 (9). pp. 995-1003. ISSN 1746-0441
Walker, Sarah, Meisenberg, Cornelia, Bibby, Rachel A, Askwith, Trevor, Williams, Gareth, Rininsland, Frauke H, Pearl, Laurence H, Oliver, Antony W, El-Khamisy, Sherif, Ward, Simon and Atack, John R (2014) Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors. Analytical Biochemistry, 454. pp. 17-22. ISSN 0003-2697
Ward, Simon E, Harries, Mark, Aldegheri, Laura, Austin, Nigel E and et al, (2011) Integration of Lead Optimization with Crystallography for a Membrane-Bound Ion Channel Target: Discovery of a New Class of AMPA Receptor Positive Allosteric Modulators. Journal of Medicinal Chemistry, 54 (1). pp. 78-94. ISSN 0022-2623
Thewlis, Kevin M, Aldegheri, Laura, Harries, Mark H, Mookherjee, Claudette, Oliosi, Beatrice and Ward, Simon E (2010) N-Substituted pyrrolidines and tetrahydrofurans as novel AMPAR positive modulators. Bioorganic and Medicinal Chemistry Letters, 20 (23). pp. 7116-7119. ISSN 0960-894X
Ward, Simon E and Harries, Mark (2010) Recent Advances in the Discovery of Selective AMPA Receptor Positive Allosteric Modulators. Current Medicinal Chemistry, 17 (30). pp. 3503-3513. ISSN 1875-533X
Ward, Simon, Bax, Benjamin D and Harries, Mark (2010) Challenges for and current status of research into positive modulators of AMPA receptors. British Journal of Pharmacology, 160 (2). pp. 181-190. ISSN 0007-1188
Ward, Simon E and Watson, Jeannette M (2010) Recent Advances in the Discovery of Selective and Non-Selective 5-HT1D Receptor Ligands. Current Topics in Medicinal Chemistry, 10 (5). pp. 479-492. ISSN 1873-4294
Leslie, Colin P, Biagetti, Matteo, Bison, Silvia, Bromidge, Steven M, Di Fabio, Romano, Donati, Daniele, Falchi, Alessandro, Garnier, Martine J, Jaxa-Chamiec, Albert, Manchee, Gary, Merlo, Giancarlo, Pizzi, Domenica A, Stasi, Luigi P, Tibasco, Jessica, Vong, Antonio, Ward, Simon E and Zonzini, Laura (2010) Discovery of 1-(3-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone (GSK163090), a Potent, Selective, and Orally Active 5-HT(1A/B/D) Receptor Antagonist. Journal of Medicinal Chemistry, 53 (23). pp. 8228-8240. ISSN 0022-2623
Ward, Simon, Harries, M, Aldegheri, L, Andreotti, D and et al, (2010) Discovery of N-[(2S)-5-(6-Fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a Novel Clinical AMPA Receptor Positive Modulator. Journal of Medicinal Chemistry, 53 (15). pp. 5801-5812. ISSN 0022-2623
Alderton, W, Karran, E and Ward, Simon (2009) Current and Future Perspectives in Psychiatric Drug Discovery. Drug news & perspectives, 22 (6). pp. 360-364. ISSN 0214-0934
Ward, Simon E, Eddershaw, Peter, Flynn, Sean T, Gordon, Laurie, Lovell, Peter J, Moore, Susan H, Scott, Claire M, Smith, Paul W, Thewlis, Kevin M and Wyman, Paul A (2009) Studies on a series of potent, orally bioavailable, 5-HT1 receptor ligands-Part II. Bioorganic and Medicinal Chemistry Letters, 19 (2). pp. 428-432. ISSN 0960-894X
Ward, Simon E, Eddershaw, Peter J, Scott, Claire M, Gordon, Laurie J, Lovell, Peter J, Moore, Susan H, Smith, Paul W, Starr, Kathryn R, Thewlis, Kevin M and Watson, Jeannette M (2008) Discovery of potent, orally bioavailable, selective 5-HT1A/B/D receptor antagonists. Journal of Medicinal Chemistry, 51 (10). pp. 2887-2890. ISSN 0022-2623
Ward, Simon (2008) Antagonists of the human adenosine A(2A) receptor. Part 1: Discovery and synthesis of thieno[3,2-d] pyrimidine-4-methanone derivatives. Bioorganic and Medicinal Chemistry Letters, 18 (9). pp. 2916-2919. ISSN 0960894X
Book Section
Ward, Simon (2014) AMPA receptor positive allosteric modulators – a case history. In: Cox, Brian and Gosling, Martin (eds.) Ion channel drug discovery. RSC drug discovery . Royal Society of Chemistry, pp. 105-134. ISBN 9781849731867
Edited Book
Davis, Andrew and Ward, Simon E, eds. (2014) The handbook of medicinal chemistry: principles and practice. Royal Society of Chemistry. ISBN 9781849736251
Patent
The University of Sussex, Cardiff University, University College Cardiff Consultants Limited; Ward, Simon; Beswick, Paul; Pennicott, Lewis; Reuillon, Tristan; Chuckowree, Irina; Villalonga-Barber, Carolina; Porter, Roderick (2019) Compounds that modulates AMPA receptor function. PCT/GB2019/050578.
The University of Sussex; Ward, Simon; Beswick, Paul; Penicott, Lewis; Reuillon, Tristan (2018) AMPA receptor potentiators. PCT/GB2018/050370.
Gibbs, Ayana Alice; Ward, Simon Edward; Pennicott, Lewis Elliot (2013) Neurodevelopmental disorders. .
Convergence Pharmaceuticals Ltd; Beswick, Paul J; Gleave, Robert J; Hachisu, Shuji; Vile, Sadie; Bertheleme, Nicolas; Ward, Simon E (2012) Tetrazole compounds as calcium channel blockers. PCT/GB2011/051276.
Glaxo Group Ltd; Bradley, Daniel M; Cardullo, Francesca; Marshall, Howard; Marzorati, Paola; Pozzan, Alfonso; Ward, Simon E (2010) Compounds which potentiate the AMPA receptor and uses thereof in medicine. WO/2010/066658.
Glaxo Group Ltd; Coulton, Steven; Gilpin, Martin; Ward, Simon E (2010) N-inden-2-yl-isopropylsulfonamides as AMPA receptor potentiators. PCT/EP2009/065263.
Glaxo Group Ltd; Ward, Simon, E; Bertheleme, Nicolas (2010) Compounds which potentiate AMPA receptor and uses thereof in medicine. PCT/EP2009/062652.
Convergence Pharmaceuticals Ltd; Heer, Jag P; Norton, David; Ward, Simon E (2010) Pyrazolo [1, 5-A] pyrimidine derivatives. PCT/EP2009/059013.
Glaxo Group Ltd; Thewlis, Kevin M; Ward, Simon E (2009) Compounds which potentiate the AMPA receptor and uses thereof in medicine. PCT/EP2009/050607.
Glaxo Group Ltd; Thewlis, Kevin M; Ward, Simon E (2009) Compounds which potentiate the AMPA receptor and uses thereof in medicine. PCT/EP2009/050608.
Glaxo Group Ltd; Bertheleme, Nicolas; Chan, Wai N; Scott, Jacqueline S; Ward, Simon E (2009) Compounds which potentiate the AMPA receptor and uses thereof in medicine. PCT/EP2008/067681.
Glaxo Group Ltd; Chan, Wai N; Harrison, Stephen; Hughes, Owen R; Neesom, James K; Thewlis, Kevin M; Ward, Simon E. (2009) Compounds which potentiate AMPA receptor and uses thereof in medicine. PCT/EP2008/064407.
Glaxo Group Ltd; Chan, Wai N; Thewlis, Kevin M; Ward, Simon E (2009) Thiazoles which potentiate AMPA receptor and medicinal uses thereof. PCT/EP2008/064408.
Glaxo Group Ltd; Bradley, Daniel M; Thewlis, Kevin M; Ward, Simon E (2008) Compounds which potentiate AMPA receptor and uses thereof in medicine. PCT/EP2008/056961.
Glaxo Group Ltd; Bertheleme, Nicolas; Bradley, Daniel M; Cardullo, Francesca; Merlo, Giancarlo; Pozzan, Alfonso; Scott, Jaqueline S; Thewlis, Kevin M; Ward, Simon E (2008) Compounds which potentiate AMPA receptor and uses thereof in medicine. PCT/EP2008/053194.
Glaxo Group Ltd; Bradley, Daniel M; Chan, Wai N; Harrison, Stephen A; Thewlis, Kevin M; Ward, Simon E (2008) Compounds which potentiate AMPA receptor and uses thereof in medicine. PCT/EP2008/052906.
Glaxo Group Ltd; Bradley, Daniel M; Thewlis, Kevin M; Ward, Simon E (2008) Compounds which potentiate glutamate receptor and uses thereof in medicine. PCT/GB2005/008562.
Glaxo Group Ltd; Bradley, Daniel M; Chan, Wai n; Thewlis, Kevin M; Ward, Simon E (2008) Compounds which potentiate AMPA receptor and uses thereof in medicine. PCT/EP2007/061794.
Glaxo Group Ltd; Bradley, Daniel M; Chan, Wai N; Ward, Simon E (2008) Compounds which potentiate AMPA receptor and uses thereof in medicine. PCT/EP2008/056971.