Selected publications

 

2019

• Bigot, N., Day, M., Baldock, R. A., Watts, F., Oliver, A., & Pearl, L. (2019). Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint. eLIfe, 8, 1-28. doi:10.7554/eLife.44353.001
  Article. View on figshare.

2018

• Lu, W. -T., Hawley, B. R., Skalka, G. L., Baldock, R. A., Smith, E. M., Bader, A. S., . . . Bushell, M. (2018). Drosha drives the formation of DNA:RNA hybrids around DNA break sites to facilitate DNA repair. Nature Communications, 9(532), 1-13. doi:10.1038/s41467-018-02893-x
  Article. View on figshare.

2016

• Watts, F. (2016). Repair of DNA double-strand breaks in heterochromatin. Biomolecules, 6(4), 47 ( pages). doi:10.3390/biom6040047
  Article. View on figshare.
• Jongjitwimol, J., Baldock, R. A., Morley, S., & Watts, F. (2016). Sumoylation of eIF4A2 affects stress granule formation. Journal of Cell Science, 129(12), 2407-2415. doi:10.1242/jcs.184614
  Article. View on figshare.
• Densham, R. M., Garvin, A. J., Stone, H. R., Strachan, J., Baldock, R. A., Daza-Martin, M., . . . Morris, J. R. (2016). Human BRCA1-BARD1 ubiquitin ligase activity counters chromatin barriers to DNA resection. Nature Structural and Molecular Biology, 23(7), 647-655. doi:10.1038/nsmb.3236
  Article. View on figshare.

2015

• Baldock, R. A., Day, M., Wilkinson, O. J., Cloney, R., Jeggo, P., Oliver, A., . . . Pearl, L. (2015). ATM localization and heterochromatin repair depend on Direct Interaction of the 53BP1-BRCT2 domain with ?H2AX. Cell Reports, 13(10), 2081-2089. doi:10.1016/j.celrep.2015.10.074
  Article. View on figshare.

2014

• Watts, F., Baldock, R., Jongjitwimol, J., & Morley, S. J. (2014). Weighing up the possibilities: controlling translation by ubiquitylation and sumoylation. Translation, 2(2), pages. doi:10.4161/2169074X.2014.959366
  Article. View on figshare.
• Garg, M., Gurung, R. L., Mansoubi, S., Ahmed, J. O., Dave, A., Watts, F., & Bianchi, A. (2014). Tpz1TPP1 SUMOylation reveals evolutionary conservation of SUMO-dependent Stn1 telomere association. EMBO Reports, 15(8), 871-877. doi:10.15252/embr.201438919
  Article. View on figshare.
• Jongjitwimol, J., Feng, M., Zhou, L., Wilkinson, O., Small, L., Baldock, R., . . . Watts, F. (2014). The S. pombe translation initiation factor eIF4G is sumoylated and associates with the SUMO protease Ulp2. PLoS ONE, 9(5), pages. doi:10.1371/journal.pone.0094182
  Article. View on figshare.

2013

• Watts, F. (2013). Starting and stopping SUMOylation. What regulates the regulator?. Chromosoma, 122(6), 451-463. doi:10.1007/s00412-013-0422-0
  Article. View on figshare.

2011

• Watts, F., & Hoffmann, E. (2011). SUMO meets meiosis: an encounter at the synaptonemal complex: SUMO chains and sumoylated proteins suggest that heterogeneous and complex interactions lie at the centre of the synaptonemal complex. BioEssays, 33, 529-33.
  Article. View on figshare.

2010

• Boyd, L. K., Mercer, B., Thompson, D., Main, E., & Watts, F. (2010). Characterisation of the SUMO-like domains of Schizosaccharomyces pombe Rad60. PLoS ONE, 5(9), 1-11. doi:10.1371/journal.pone.0013009
  Article. View on figshare.
• Watts, F., & Brissett, N. (2010). Linking up and interacting with BRCT domains. DNA Repair, 9(2), 103-8. doi:10.1016/j.dnarep.2009.10.010
  Article. View on figshare.
• Spirek, M., Estreicher, A., Csaszar, E., Wells, J., McFarlane, R. J., Watts, F., & Loidl, J. (2010). Sumoylation is required for normal development of linear element and wild-type meiotic recombination in Schizosaccharomyces pombe. Chromosoma, 9(11), 59-72. doi:10.1007/s00412-009-0241-5
  Article. View on figshare.

2009

• Skilton, A., Outwin, E., Mercer, B., Ho, J. C. Y., & Watts, F. (2009). SUMO chain formation is required for response to replication arrest in S. pombe. PLoS ONE, 4(8), pages. doi:10.1371/journal.pone.0006750
  Article. View on figshare.

2008

• Kilkenny, M. L., Doré, A. S., Roe, S. M., Nestoras, K., Ho, J. C. Y., Watts, F., & Pearl, L. (2008). Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signalling. Genes & Development, 22(15), 2034-47. doi:10.1101/gad.472808
  Article. View on figshare.

2007

• Watts, F., Skilton, A., Ho, J. C., Boyd, L. K., Trickey, M. A., Gardner, L., & Ogi, F. -X. (2007). The role of Schizosaccharomyces pombe SUMO ligases in genome stability. Biochemical Society Transactions, 35(6), 1379-1384. doi:10.1042/BST0351379
  Article. View on figshare.
• Watts, F. (2007). The role of SUMO in chromosome segregation.. Chromosoma, 116(1), 15-20. doi:10.1007/s00412-006-0079-z
  Article. View on figshare.

2006

• Frampton, J., Irmisch, A., Green, C. M., Neiss, A., Trickey, M., Ulrich, H. D., . . . Lehmann, A. (2006). Postreplication Repair and PCNA Modification in Schizosaccharomyces pombe. Molecular Biology of the Cell, 17(7), 2976-2985. doi:10.1091/mbc.E05-11-1008
  Article. View on figshare.
• Watts, F. (2006). Sumoylation of PCNA: Wrestling with recombination at stalled replication forks. DNA Repair, 5(3), 399-403. doi:10.1016/j.dnarep.2005.11.002
  Article. View on figshare.

2005

• Shin, J., Choi, E. S., Kim, H. S., Ho, J. C., Watts, F., Park, S. D., & Jang, Y. K. (2005). SUMO modification is involved in the maintenance of heterochromatin stability in fission yeast. Molecular Cell, 19(6), 817-828. doi:10.1016/j.molcel.2005.08.021
  Article. View on figshare.
• Spink, K., Ho, J. C., Tanaka, K., Watts, F., & Chambers, A. (2005). The telomere-binding protein Taz1p as a target for modification by a SUMO-1 homologue in fission yeast. Biochemical Genetics, 43(3-4), 103-17. doi:10.1007/s10528-005-1503-4
  Article. View on figshare.
• Zhou, L., & Watts, F. (2005). Nep1, a Schizosaccharomyces pombe deneddylating enzyme. Biochemical Journal, 389(Pt 2), 307-314. doi:10.1042/BJ20041991
  Article. View on figshare.
• Sergeant, J., Taylor, E., Palecek, J., Fousteri, M., Andrews, E., Sweeney, S., . . . Lehmann, A. (2005). Composition and Architecture of the Schizosaccharomyces pombe Rad18 (Smc5-6) Complex. Molecular and Cellular Biology, 25(1), 172-184. doi:10.1128/MCB.25.1.172-184.2005
  Article. View on figshare.
• Andrews, E. A., Palecek, J., Sergeant, J., Taylor, E., Lehmann, A., & Watts, F. (2005). Nse2, a component of the Smc5-6 complex, is a SUMO ligase required for the response to DNA damage. Molecular and Cellular Biology, 25(1), 185-196. doi:10.1128/MCB.25.1.185-196.2005
  Article. View on figshare.

2004

• Watts, F. (2004). SUMO modification of proteins other than transcription factors. Seminars in Cell & Developmental Biology, 15(2), 211-220. doi:10.1016/j.semcdb.2003.12.002
  Article. View on figshare.

2003

• Ho, J. C., & Watts, F. (2003). Characterisation of SUMO conjugating enzyme mutants in Schizosaccharomyces pombe identifies a dominant negative allele which severely reduces SUMO conjugation. Biochemical Journal, 21, pages. doi:10.1042/BJ20021645
  Article. View on figshare.
• Hinks, J., Roe, M., Ho, J. C., Watts, F., Phelan, J., McAllister, M., & Pearl, L. (2003). Expression, purification and preliminary X-ray analysis of the BRCT domain from Rhp9/Crb2. Acta Crystallographica Section D: Biological Crystallography, 59(Pt 7), 1230-1233.. doi:10.1107/S0907444903007054
  Article. View on figshare.

2002

• Taylor, D. L., Ho, J. C. Y., Oliver, A., & Watts, F. Z. (2002). Cell-cycle-dependent localisation of Ulp1, a Schizosaccharomyces pombe Pmt3 (SUMO)-specific protease. Journal of Cell Science, 115(6), 1113-1122.
  Article.

2001

• Ho, J. C., Warr, N. J., Shimizu, H., & Watts, F. (2001). SUMO modification of Rad22, the Schizosaccharomyces pombe homologue of the recombination protein Rad52. Nucleic Acids Research, 29(20), 4179-4186.
  Article. View on figshare.

1999

• Wilson, S., Warr, N., Taylor, D. L., & Watts, F. Z. (1999). The role of Schizosaccharomyces pombe Rad32, the Mre11 homologue, and other DNA damage response proteins in non-homologous end joining and telomere length maintenance. Nucleic Acids Research, 27(13), 2655-2661. doi:10.1093/nar/27.13.2655
  Article. View online.

1998

• Wilson, S., Tavassoli, M., & Watts, F. Z. (1998). Schizosaccharomyces pombe Rad32 protein: A phosphoprotein with an essential phosphoesterase motif required for repair of DNA double strand breaks. Nucleic Acids Research, 26(23), 5261-5269. doi:10.1093/nar/26.23.5261
  Article. View online.

1997

• Willson, J., Wilson, S., Warr, N., & Watts, F. Z. (1997). Isolation and characterization of the Schizosaccharomyces pombe rhp9 gene: A gene required for the DNA damage checkpoint but not the replication checkpoint. Nucleic Acids Research, 25(11), 2138-2145. doi:10.1093/nar/25.11.2138
  Article. View online.
• Shayeghi, M., Doe, C. L., Tavassoli, M., & Watts, F. Z. (1997). Characterisation of schizosaccharomyces pombe rad31, a UBA-related gene required for DNA damage tolerance. Nucleic Acids Research, 25(6), 1162-1169. doi:10.1093/nar/25.6.1162
  Article. View online.
• May, K. M., Watts, F., Jones, N., & Hyams, J. S. (1997). Type II myosin involved in cytokinesis in the fission yeast, Schizosaccharomyces pombe. Cell Motility and the Cytoskeleton, 38(4), 385-396.
  Article. View on figshare.

1996

• Albury, M., Dudley, P., Watts, F., & Moore, A. (1996). Targeting the plant alternative oxidase protein to i Schizosaccharomyces pombe mitochondria confers cyanide-insensitive respiration. Journal of Biological Chemistry, 271(29), 17062-17066. doi:10.1074/jbc.271.29.17062
  Article. View on figshare.

1995

• Tavassoli, M., Shayeghi, M., Nasim, A., & Watts, F. (1995). Cloning and characterisation of the Schizosaccharomyces pombe rad32 gene: A gene required for repair of double strand break and recombination. Nucleic Acids Research, 23(3), 383-388.
  Article. View on figshare.
• Lehmann, A., Walicka, M., Griffths, D. J., Murray, J., Watts, F., McCready, S., & Carr, A. (1995). The rad18 Gene of Schizosaccharomyces pombe Defines a New Subgroup of the SMC Superfamily Involved in DNA Repair. Molecular and Cellular Biology, 15(12), 7067-7080.
  Article. View on figshare.

1994

• Watts, F., Butt, N., Layfied, P., Machuka, J., Burke, J. F., & Moore, A. (1994). Floral expression of a gene encoding an E2-related ubiquitin-conjugating protein from Arabidopsis thaliana. Plant Molecular Biology, 26(1), 445-451. doi:10.1007/BF00039553
  Article. View on figshare.
• Murray, J., Tavassoli, M., Al-Harithy, R., Sheldrick, K. S., Lehmann, A., Carr, A., & Watts, F. (1994). Structural and functional conservation of the human homolog of the Schizosaccharomyces pombe rad2 gene, which is required for chromosome segregation and recovery from DNA damage. Molecular and Cellular Biology, 14(7), 4878-4888.
  Article. View on figshare.
• Moore, A., Wood, C. K., & Watts, F. (1994). Protein import into plant mitochondria. Annual Review of Plant Physiology and Plant Molecular Biology, 45, 545-575. doi:10.1146/annurev.pp.45.060194.002553
  Article. View on figshare.

1993

• Carr, A., Sheldrick, K. S., Murray, J., Al-Harithy, R., Watts, F., & Lehmann, A. (1993). Evolutionary conservation of excision repair in Schizosaccharomyces pombe: Evidence for a family of sequences related to the Saccharomyces cerevisiae RAD2 gene. Nucleic Acids Research, 21(6), 1345-1349. doi:10.1093/nar/21.6.1345
  Article. View on figshare.
• Mather, K., Watts, F., Carroll, M., Whitehead, P., Swash, M., Cairn, N., & Burke, J. (1993). Antibody to an abnormal protein in amyotrophic lateral sclerosis identifies Lewy body-like inclusions in ALS and Lewy bodies in Parkinson's disease. Neuroscience Letters, 160(1), 13-16. doi:10.1016/0304-3940(93)90905-Z
  Article. View on figshare.
• Doe, C. L., Murray, J., Shayeghi, M., Hoskins, M., Lehmann, A., Carr, A., & Watts, F. (1993). Cloning and characterisation of the Schizosaccharomyces pombe rad8 gene, a member of the SNF2 helicase family. Nucleic Acids Research, 21(25), 5964-5971. doi:10.1093/nar/21.25.5964
  Article. View on figshare.

1992

• Murray, J., Doe, C. L., Schenk, P., Carr, A., Lehmann, A., & Watts, F. (1992). Cloning and characterisation of the S.pombe rad15 gene, a homologue to the S.cerevisiae RAD3 and human ERCC2 genes. Nucleic Acids Research, 20(11), 2673-2678.
  Article. View on figshare.
• Moore, A., Walters, A. J., Thorpe, J., Fricaud, A. -C., & Watts, F. (1992). Schizosaccharomyces pombe mitochondria: morphological, respiratory and protein import characteristics. Yeast, 8(11), 923-933. doi:10.1002/yea.320081103
  Article. View on figshare.
• Watts, F., Walters, A. J., & Moore, A. (1992). Characterisation of PHSP1, a cDNA encoding a mitochondrial HSP70 from Pisum sativum. Plant Molecular Biology, 18(1), 23-32. doi:10.1007/BF00018453
  Article. View on figshare.

1991

• Fenech, M., Carr, A., Murray, J., Watts, F., & Lehmann, A. (1991). Cloning and characterization of the rad4 gene of Schizosaccharomyces pombe; a gene showing short regions of sequence similarity to the human XRCC1 gene. Nucleic Acids Research, 19(24), 6737-6741. doi:10.1093/nar/19.24.6737
  Article. View on figshare.
• Lehmann, A., Carr, A., Watts, F., & Murray, J. (1991). DNA repair in the fission yeast, Schizosaccharomyces pombe. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 250(1-2), 205-210. doi:10.1016/0027-5107(91)90177-P
  Article. View on figshare.
• Murray, J., Carr, A., Lehmann, A., & Watts, F. (1991). Cloning and characterisation of the rad9 DNA repair gene from Schizosaccharomyces pombe. Nucleic Acids Research, 19(13), 3525-3531. doi:10.1093/nar/19.13.3525
  Article. View on figshare.
• Broughton, B. C., Berbet, N., Murray, J., Watts, F., Koken, M. H. M., Lehmann, A., & Carr, A. (1991). Assignment of ten DNA repair genes from Schizosaccharomyces pombe to chromosomal NotI restriction fragments. Molecular and General Genetics MGG, 228(3), 470-472. doi:10.1007/BF00260641
  Article. View on figshare.

1990

• Sweeney, F. P., Watts, F. Z., Pocklington, M. J., & Orr, E. (1990). The MYO1 gene from Saccharomyces cerevisiae: Its complete nucleotide sequence. Nucleic Acids Research, 18(23), 7147. doi:10.1093/nar/18.23.7147
  Article. View online.
• Murray, J. M., & Watts, F. Z. (1990). Isolation of a schizosaccharomyces pombe homologue to the rat ribosomal protein, L7. Nucleic Acids Research, 18(15), 4590. doi:10.1093/nar/18.15.4590
  Article. View online.
• Powell, M. J., & Watts, F. (1990). Isolation of a gene encoding a mitochondrial HSP70 protein from Schizosaccharomyces pombe. Gene, 95(1), 105-110. doi:10.1016/0378-1119(90)90420-V
  Article. View on figshare.

1989

• Watts, F., & Moore, A. (1989). Nucleotide sequence of a full length cDNA clone encoding a polyubiquitin gene from Pisum sativum.. Nucleic Acids Research, 17(23), pages.
  Article. View on figshare.

1987

• Watts, F. Z., Shiels, G., & Orr, E. (1987). The yeast MYO1 gene encoding a myosin-like protein required for cell division.. The EMBO journal, 6(11), 3499-3505. doi:10.1002/j.1460-2075.1987.tb02675.x
  Article. View online.

1985

• Watts, F. Z., Miller, D. M., & Orr, E. (1985). Identification of myosin heavy chain in Saccharomyces cerevisiae. Nature, 316(6023), 83-85. doi:10.1038/316083a0
  Article. View online.

1983

• Watts, F., Castle, C., & Beggs, J. (1983). Aberrant splicing of Drosophila alcohol dehydrogenase transcripts in Saccharomyces cerevisiae.. The EMBO journal, 2(11), 2085-2091. doi:10.1002/j.1460-2075.1983.tb01704.x
  Article. View online.

1979

• Edwards, D. R. W., Taylor, J. B., Wakeling, W. F., Watts, F. Z., & Johnston, I. R. (1979). Studies on the prereplicative phase of the cell cycle in Saccharomyces cerevisiae. Cold Spring Harbor Symposia on Quantitative Biology, 43(1), 577-586. doi:10.1101/sqb.1979.043.01.064
  Article. View online.

Unpublished works

• [Item 24375 has been withdrawn from the repository] (n.d.).
  Article.

Watts, F.Z. and Hofmann, E.  (2011) SUMO meets meiosis: an encouner at the synaptonemal complex. Bioessays 33, 529-37

Boyd, L.K., Mercer, B., Main, E, Thompson, D. Watts, F.Z. (2010) Characterisation of the SUMO-like domains of Schizosaccahromyces pombe Rad60. PlosOne, Sep 27;5(9):e13009

Watts F.Z. and Brissett N.C. (2010) Linking up and interacting with BRCT domains. DNA Repair 9, 103-8

Spirek M., Estreicher A., Csaszar E., Wells J., McFarlane R.J., Watts F.Z. and Loidl J. (2010) Sumoylation is required for normal development of linear element and wild-type meiotic recombination in Schizosaccharomyces pombe. Chromosoma. 9:59-72.

Skilton A., Ho J.C., Mercer B., Outwin E. and Watts F.Z. (2009) SUMO chain formation is required for response to replication arrest in S. pombe. PlosONE 4, e6750 

 Kilkenney, M.L. Dore, A., Roe, S.M., Nestoras, K., Ho, J.C.Y., Watts, F.Z. and Pearl, L.H.  (2008) Structural and functional analysis of the Crb2-BRCT₂ domain reveals distinct roles in checkpoint signalling and DNA damage repair Genes and Dev. 22, 2034-47.

Watts, F. Z., Skilton, A., Ho, J. C., Boyd, L. K., Trickey, M. A., Gardner, L., Ogi, F. X., Outwin, E. A. (2007) The role of Schizosaccharomyces pombe SUMO ligases in genome stability. Biochem. Soc. Trans. 35, 1379-84. 

Watts, F.Z. (2007) The role of SUMO in chromosome segregation. Chromosoma 116, 15-20.

Frampton, J,., Irmisch, A., Neiss, A., Trickey, M., Green, C.M., Ulrich, H.D., Furuya, K., Watts, F.Z., Carr, A.M. and Lehmann, A.R. (2006) Post-replication repair and PCNA modification in Schizosaccharomyces pombe. Mol Biol Cell 17, 2976-85.

Watts, F.Z. (2006) Sumoylation of PCNA: Wrestling with recombination at stalled replication forks. DNA Repair 5, 399-403.

Shin, J.A, Chin, E.S., Kim, H.S. Ho, J.C.Y., Watts, F.Z., Park, S.D, and Jang, Y.K (2005) SUMO modification is involved in the maintenance of heterochromatin stability in fission yeast. Mol Cell. 19, 817-28.

Spink, K, Ho, J.C.Y, Tanaka, K., Watts, F.Z. and Chambers, A. (2005) The telomere-binding protein Taz1p as a target for modification by a SUMO-1 homologue in fission yeast. Biochem Genet. 43, 103-17.

Zhou, L. and Watts, F.Z. (2005) Nep1, an S. pombe deneddylating enzyme. Biochem J.  389, 307-14.

Andrews E.A., Palecek J., Sergeant J., Taylor E., Lehmann A.R., and Watts F.Z. (2005) Nse2, a component of the Smc5-6 complex, is a SUMO ligase required for the response to DNA damage. Mol Cell Biol. 25, 185-196.

Sergeant J., Taylor E., Palecek J., Fousteri M., Andrews E.A., Sweeney S., Shinagawa H., Watts F.Z., and Lehmann A.R. (2005) Composition and architecture of the Schizosaccharomyces pombe Rad18 (Smc5-6) complex. Mol. Cell Biol. 25, 172-184.

Hinks J.A., Roe M., Ho J.C., Watts F.Z., Phelan J., McAllister M., and Pearl L.H. Expression, purification and preliminary X-ray analysis of the BRCT domain from Rhp9/Crb2. Acta Crystallogr D Biol Crystallogr. (2003) 59, 1230-3

Ho, J.C.Y. and Watts, F.Z. Characterization of SUMO-conjugating enzyme mutants in Schizosaccharomyces pombe identifies a dominant-negative allele that severely reduces SUMO conjugation. Biochem J. (2003) 372, 97-104

Taylor, D.L. Ho, J.C.Y., Oliver, A. and Watts, F.Z. Cell-cycle-dependent localisation of Ulp1, a Schizosaccharomyces pombe Pmt3 (SUMO)-specific protease. J. Cell Sci. (2002) 115, 1113-1122.

Ho, J.C.Y., Warr, N.J., Shimizu, H., Watts, F.Z. SUMO modification of Rad22, the Schizosaccharomyces pombe homologue of the recombination protein Rad52.  Nucl. Acids Res. (2001) 29, 4179-86.