Publications

H-index 49

 

http://orcid.org/0000-0001-9335-7751

  1. Al-Hilaly YK, Biasetti L, Blakeman BJ, Pollack SJ, Zibaee S, Abdul-Sada A, Thorpe JR, Xue WF, Serpell LC. The involvement of dityrosine crosslinking in alpha-synuclein assembly and deposition in Lewy Bodies in Parkinson's disease. Scientific reports. 2016;6:39171
  2. Al-Garawi ZS, Kostakis GE, Serpell LC. Chemically and thermally stable silica nanowires with a beta-sheet peptide core for bionanotechnology. J Nanobiotechnology. 2016;14(1):79
  3. Gallardo R, Ramakers M, De Smet F, Claes F, Khodaparast L, Khodaparast L, et al. Serpell LC, Schymkowitz J, Rousseau F. De novo design of a biologically active amyloid. Science. 2016;354(6313)
  4. Sant'Anna R, Fernandez MR, Batlle C, Navarro S, de Groot NS, Serpell L, Ventura, S. (2016) Characterization of Amyloid Cores in Prion Domains. Scientific reports. 6, 34274
  5. Marshall, K.E*., Vadukul, D*., Dahal, L*., Theisen, A*., Fowler, M., Al-Hilaly, Y*., Ford, L*., Kemenes, G., Staras, K., Serpell, LC.  (2016) A critical role for self-assembly of Abeta1-42 in neurodegeneration. Scientific reports, 6, 30182-95
  6. Joyce, R.E., Williams, T.L*., Serpell, L.C., Day, I.J. (2016)  Monitoring changes of paramagnetically-shifted 31P signals in phospholipid vesicles.  Chemical Physics Letters 648, 124-129
  7. Bukar Maina, M*., Al-Hilaly, Y. K*. and Serpell, L.C. (2016) Nuclear tau and its potential role in Alzheimer’s disease. Biomolecules. 6, 9; doi:10.3390/biom6010009
  8. Williams, T. L*., Serpell, L. C., and Urbanc, B. (2015) Stabilization of native amyloid beta-protein oligomers by Copper and Hydrogen peroxide Induced Cross-linking of Unmodified Proteins (CHICUP). Biochim Biophys Acta1864, 249-259
  9. Williams, T. L*., Urbanc, B., Marshall, K. E*., Vadukul, D. M*., Jenkins, A. T., and Serpell, L. C. (2015) Europium as an inhibitor of Amyloid-beta(1-42) induced membrane permeation. FEBS Lett589, 3228-3236
  10. Al-Garawi, Z. S*., Thorpe, J. R., and Serpell, L. C. (2015) Silica Nanowires Templated by Amyloid-like Fibrils. Angew Chem Int Ed Engl54, 13327-13331
  11. Hubin, E., Deroo, S., Schierle, G. K., Kaminski, C., Serpell, L., Subramaniam, V., van Nuland, N., Broersen, K., Raussens, V., and Sarroukh, R. (2015) Two distinct beta-sheet structures in Italian-mutant amyloid-beta fibrils: a potential link to different clinical phenotypes. Cellular and molecular life sciences : CMLS72, 4899-4913
  12. Ratnayaka, J. A., Serpell, L. C., and Lotery, A. J. (2015) Dementia of the eye: the role of amyloid beta in retinal degeneration. Eye29, 1013-1026
  13. Burgess, N. C., Sharp, T. H., Thomas, F., Wood, C. W., Thomson, A. R., Zaccai, N. R., Brady, R. L., Serpell, L. C., and Woolfson, D. N. (2015) Modular Design of Self-Assembling Peptide-Based Nanotubes. J Am Chem Soc137, 10554-10562
  14. Ford, L*., Crossley, M., Williams, T*., Thorpe, J. R., Serpell, L. C.*, and Kemenes, G*. (*joint corresponding authors) (2015) Effects of Abeta exposure on long-term associative memory and its neuronal mechanisms in a defined neuronal network. Scientific reports5, 10614
  15. Beerten, J., Van Durme, J., Gallardo, R., Capriotti, E., Serpell, L., Rousseau, F., and Schymkowitz, J. (2015) WALTZ-DB: a benchmark database of amyloidogenic hexapeptides. Bioinformatics31, 1698-1700
  16. Kaltofen S, Li C, Huang PS, Serpell LC, Barth A, Andre I. Computational de novo design of a self-assembling peptide with predefined structure. Journal of molecular biology. 2015;427:550-62.
  17. Langkilde AE, Morris KL*, Serpell LC, Svergun DI, Vestergaard B. The architecture of amyloid-like peptide fibrils revealed by X-ray scattering, diffraction and electron microscopy. Acta crystallographica Section D, Biological crystallography. 2015;71:882-95.
  18. Morris KL*, Chen L, Rodger A, Adams DJ, Serpell LC. Structural determinants in a library of low molecular weight gelators. Soft matter. 2015;11:1174-81.
  19. Colquhoun C, Draper ER, Eden EG, Cattoz BN, Morris KL*, Chen L, McDonald TO, Terry AE, Griffiths PC, Serpell LC, Adams DJ. The effect of self-sorting and co-assembly on the mechanical properties of low molecular weight hydrogels. Nanoscale. 2014;6:13719-25.
  20. Sanders DW, Kaufman SK, DeVos SL, Sharma AM, Mirbaha H, Li A, Barker SJ, Foley AC*, Thorpe JR, Serpell LC, Miller TM, Grinberg LT, Seeley WW, Diamond MI. Distinct tau prion strains propagate in cells and mice and define different tauopathies. Neuron. 2014;82:1271-88.
  21. Marshall KE*, Marchante R, Xue WF, Serpell LC. The relationship between amyloid structure and cytotoxicity. Prion. 2014;8. 28860
  22. Mangione PP, Porcari R, Gillmore JD, Pucci P, Monti M, Porcari M, Giorgetti S, Marchese L, Raimondi S, Serpell LC, Chen W, Relini A, Marcoux J, Clatworthy IR, Taylor GW, Tennent GA, Robinson CV, Hawkins PN, Stoppini M, Wood SP, Pepys MB, Bellotti V. Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis. Proceedings of the National Academy of Sciences of the United States of America. 2014;111:1539-44.
  23. Al-Hilaly YK*, Williams TL*, Stewart-Parker M*, Ford L*, Skaria E*, Cole M*, Bucher WG*, Morris KL*, Sada AA, Thorpe JR, Serpell LC. A central role for dityrosine crosslinking of Amyloid-beta in Alzheimer's disease. Acta neuropathologica communications. 2013;1:83.
  24. Xu C, Liu R, Mehta AK, Guerrero-Ferreira RC, Wright ER, Dunin-Horkawicz S, Morris K, Serpell LC, Zuo X, Wall JS, Conticello VP. Rational design of helical nanotubes from self-assembly of coiled-coil lock washers. Journal of the American Chemical Society. 2013;135:15565-78.
  25. Morris KL*, Chen L, Raeburn J, Sellick OR, Cotanda P, Paul A, Griffiths PC, King SM, O'Reilly RK, Serpell LC*, Adams DJ* (*joint corresponding). Chemically programmed self-sorting of gelator networks. Nature communications. 2013;4:1480.
  26. Morris KL*, Rodger A, Hicks MR,  Debulpaep M, Schymkowitz J, Rousseau F, Serpell LC. Exploring the sequence-structure relationship for amyloid peptides. (2013) Biochem J. 450, 275-83
  27. Morris KL*, Zibaee S, Chen L, Goedert M, Sikorski P, Serpell LC. The structure of cross-beta tapes and tubes formed by an octapeptide, alphaSbeta1. Angewandte Chemie. 2013;52:2279-83.
  28. Houton KA, Morris KL*, Chen L, Schmidtmann M, Jones JT, Serpell LC, Lloyd GO, Adams DJ. On crystal versus fiber formation in dipeptide hydrogelator systems. Langmuir : the ACS journal of surfaces and colloids. 2012;28:9797-806.
  29. Serpell LC. Encylopedia for Biophysics 2013 , “X-ray fibre diffraction”, Pub. Springer  ISBN 978-3-642-16711-9
  30. Perney NM, Braddick L, Jurna M, Garbacik ET, Offerhaus HL, Serpell LC, Blanch E, Holden-Dye L, Brocklesby WS, Melvin T. Polyglutamine aggregate structure in vitro and in vivo; new avenues for coherent anti-Stokes Raman scattering microscopy. PloS one. 2012;7:e40536.
  31. Morris K.*, Serpell, LC. (2012). From molecular to supramolecular amyloid structures: contributions from fiber diffraction and electron microscopy. In “Amyloid fibrils and prefibrillar aggregates”.  Daniel Otzen Ed. Pub. Wiley. ISBN: 978-3-527-33200-7
  32. Morris K*., Serpell, LC. (2012) X-ray Fibre Diffraction Studies of Amyloid Fibrils, Amyloid Proteins: Methods and Protocols, Einar M. Sigurdsson et al. (eds.), Methods in Molecular Biology, vol. 849, 121-135
  33. Pauwels K, Williams TL*, Morris KL*, Jonckheere W, Vandersteen A, Kelly G, Schymkowitz J, Rousseau F, Pastore A, Serpell LC, et al. (2012) The structural basis for increased toxicity of pathological Abeta42:Abeta40 ratios in Alzheimer's disease. The Journal of biological chemistry,  287, 5650-5660
  34. Ye Z, Bayron Poueymiroy D, Aguilera JJ, Srinivasan S, Wang Y, Serpell LC, Colón W. (2011) Inflammation Protein SAA2.2 Spontaneously Forms Marginally Stable Amyloid Fibrils at Physiological Temperature. Biochemistry. 50, 9184-91
  35. Soura V,* Stewart Parker M*, Willliams TL*, Ratnayaka A, Atherton J, Gorringe K,* Tuffin J*, Darwent E*, Rambaran R*, Klein W, Lacor P, Staras K, Thorpe JR, Serpell LC. (2012) Visualisation of colocalisation in Ab42-administered neuroblastoma cells reveals lysosome damage and autophagosome accumulation related to cell death. Biochem J. 441 579-90.
  36. Chen L, Pont G, Morris K, Lotze G, Squires A, Serpell LC, Adams DJ. Salt-induced hydrogelation of functionalised-dipeptides at high pH. Chemical communications. 2011;47:12071-3.
  37. Williams TL*,  Johnson BRG,  Urbanc B, Jenkins ATA, Connell SDA, Serpell LC. (2011). Alzheimer's Ab42 oligomers but not fibrils simultaneously bind to and cause damage to ganglioside containing lipid membranes. Biochemical Journal. 439, 67-77
  38. Williams TL*, Serpell LC (2011). Membrane and surface interactions of the Alzheimer's Aß peptide: insights into the mechanism of cytotoxicity. FEBS J. 78, 3905-17
  39. Marshall KE*, Morris KL*, Charlton D*, O'Reilly N, Lewis L, Walden H, Serpell LC. (2011) Hydrophobic, aromatic and electrostatic interactions play a central role in amyloid fibril formation. Biochemistry. 50, 2061-71
  40. Liu B, Moloney A, Meehan S, Morris K,* Thomas SE, Serpell LC, Hider R, Marciniak SJ, Lomas DA, Crowther DC.(2011) Iron promotes the toxicity of amyloid beta peptide by impeding its ordered aggregation.J Biol Chem. 286, 4248-56
  41. Williams T*, Day, I, Serpell LC. (2010) The Effect of Alzheimer’s Ab Aggregation state on the Permeation of Biomimetic Lipid Vesicles. Langmuir, 26, 17260-8
  42. Zibaee S*, Fraser G, Jakes R, Owen D, Serpell LC, R. Crowther A, Goedert M. (2010) Human beta-Synuclein rendered fibrillogenic by designed mutations. J Biol. Chem. 285, 38555-67
  43. Adams, D, Morris, K*, Chen, L, Serpell, L, Bacsa, J, Day, G. The delicate balance between gelation and crystallisation: structural and computational investigations (2010) Soft matter 6, 4144-4156
  44. Chen, L, Revel, S, Morris K*, Spiller DG, Serpell LC and Adams DJ. (2010). Low molecular weight gelator–dextran composites. Chem. Commun., 46, 6738-6740
  45. Morris KM*, Serpell LC. From natural to designer self-assembling biomaterials: the structural characterisation of fibrous proteins using fibre diffraction. Chemical society reviews 39, 3445-3453
  46. Andersen CB, Hicks MR, Vetri V. Vandahl B, Rahbek-Nielsen H, Thøgersen H, Thøgersen IB, Enghild JJ, Serpell LC, Rischel C, Otzen D E. (2010) Glucagon fibril polymorphism reflects differences in protofilament backbone structure. J Mol. Biol 397, 932-46
  47. Marshall M*, Serpell LC. (2010) Fibres, crystals and polymorphism: the structural promiscuity of amyloidogenic peptides. Soft Matter (invited review) 6, 2110 - 2114
  48. Maurer-Stroh, S, Debulpaep, M, Kuemmerer, N, Lopez de la Paz, M, Martins, IC, Morris, KL*,  Reumers, J, Copland, A*, Serpell, L, Serrano, L, Rousseau, F, Schymkowitz, JWH (2010) An exploration of the sequence determinants of amyloid formation and the development of the Waltz prediction algorithm. Nature methods 7, 237-42
  49. Glocking S &  Serpell LC. (2010) A new species of aplanosporic Haptoglossa, H. beakesii, with vesiculate spore release. Botany, 88, 93-101
  50. Marshall K*, Hicks M, Williams TL*, Rodger A, Dafforn T, Serpell LC. A fibre to crystal switch in the Sup35 yeast prion fragment, GNNQQNY.  (2010) Biophysical J 98, 330-338
  51. Lin Chen, Kyle Morris*, Andrea Laybourn, David Elias, Matthew R. Hicks,Alison Rodger, Louise Serpell and Dave J. Adams (2010). The Self-Assembly Mechanism for a Naphthalene-Dipeptide Leading to Hydrogelation.  Langmuir 6, 5232-42.
  52. Jahn, T. Makin OS*, Morris K*, Marshall KM*, Tian, P*, Sikorski P, Serpell LC.  (2010) J. Mol. Biol. The common architecture of cross-beta amyloid,  395, 717-727 
  53. Maurstad G, Prass M, Serpell LC, Sikorski P. (2009)  Dehydration stability of amyloid fibrils studied by AFM. Eur. J. Biophys. 38, 1135-1140
  54. Marshall, KM* & Serpell, L.C. (2009) Insights into the structure of amyloid fibrils (invited review). Open Biology 2, 185-192
  55. Banwell, EF, Abelardo, ES, Adams, DJ, Birchall,MA, Corrigan, A, Donald, AM, Kirkland,M Serpell,LC,. Butler, MF and Woolfson, DN. (2009) Rational design and application of alpha-helical peptide hydrogels. Nature Materials. 8, 596-600
  56. Tamamis,P, Adler-Abramovich, L, Reches,M, Marshall, K*, Sikorski,P, Serpell, L, Gazit,E and Archontis, G (2009). Self-Assembly of Phenylalanine Oligopeptides: Insights from Experiments and Molecular Dynamics Simulations in Implicit Solvent. Biophys. J.  96, 5020-5029
  57. Marshall, K.M.* & Serpell, L.C. (2009) The structural integrity of beta-sheet assembly (invited review). Biochemical transactions 37, 671–676
  58. Benjamin M. Bulheller,, Alison Rodger,  Matthew R. Hicks, Timothy R. Dafforn, Louise C. Serpell, Karen Marshall*, Elizabeth H. C. Bromley  Patrick J. S. King, Kevin J. Channon, Derek N. Woolfson, and Jonathan D. Hirst. 29  Linear Dichroism of Some Prototypical Proteins. J. Am. Chem. Soc. 131, 13305-13314
  59. Madine J, Copland A* Serpell, L, Middleton D (2009) Cross-b spine architecture of fibrils formed by the amyloidogenic segment NFGSVQFV of medin from solid-state NMR and X-ray fibre diffraction measurements. Biochemistry. 48, 3089-3099
  60. Rambaran RN, Serpell LC. (2008) Amyloid fibrils: Abnormal protein assembly. Book chapter “Fibrous proteins” Ed. T Scheibel. Landes Bioscience
  61. Steinmetz MO, Gratin Z, Verei R, Ciani B, Stromer T, Green J, Tittman P, Schultze-Brise C, Gross H, van Gunsteren WF, Meier BH, Serpell LC, Muller SA, Kammerer RA. (2008) Atomic model of de novo designed ccb-Met amyloid-like fibrils. J. Mol. Biol. 376, 898-912.
  62. Fukuma T, Mostaert, AS, Serpell LC, Jarvis JP. (2008) Revealing molecular-level surface structure of amyloid fibrils in liquid by means of frequency modulation atomic force microscopy. Nanotechnology 19, 384010-384016.
  63. Madine J, Jack E, Stockley  P, Radford S, Serpell L, Middleton D. (2008) Structural insights into the polymorphism of amyloid-like fibrils formed by region 20-29 of amylin revealed by solid-state NMR and X-ray fibre diffraction. J. Am. Chem. Soc. 130, 14990-15001.