Dr Mark Roe

Publications from the last 10 years:

Roe SM, Wahab B, Török Z, Horváth I, Vigh L, Prodromou C. Dihydropyridines Allosterically Modulate Hsp90 Providing a Novel Mechanism for Heat Shock Protein Co-induction and Neuroprotection. Front Mol Biosci. (2018) 5 51.

Tsoureas N, Green JC, Cloke FGN, Puschmann H, Roe SM, Tizzard G. Trimerisation of carbon suboxide at a di-titanium centre to form a pyrone ring system. Chem Sci. (2018) 9 5008-5014.

Martino F, Pal M, Muñoz-Hernández H, Rodríguez CF, Núñez-Ramírez R, Gil-Carton D, Degliesposti G, Skehel JM, Roe SM, Prodromou C, Pearl LH, Llorca O. RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex. Nat Commun. (2018) 9 1501.

Blundell KL, Pal M, Roe SM, Pearl LH, Prodromou C. The structure of FKBP38 in complex with the MEEVD tetratricopeptide binding-motif of Hsp90. PLoS One. (2017) 12 e0173543.

Close AJ, Jones RN, Ocasio CA, Kemmitt P, Roe SM, Spencer J. Elaboration of tetra-orthogonally-substituted aromatic scaffolds towards novel EGFR-kinase inhibitors. Org Biomol Chem. (2016) 14 8246-52.

Gholivand K, Farshadfar K, Roe SM, Hosseini M, Gholami A. Investigation of structure-directing interactions within copper(I) thiocyanate complexes through X-ray analyses and non-covalent interaction (NCI) theoretical approach. Cryst. Eng. Comm., (2016), 18,  7104-7115.

Gholivand K, Farshadfar K, Roe SM, Gholami A, Esrafili MD. Structural and photophysical characterization of mono- and binuclear Cu(I) complexes based on carbohydrazones: a combined experimental and computational study. Cryst. Eng. Comm., (2016), 18, 2873-2884.

Kahan RJ, Cloke FGN, Roe SM, Nief F. Activation of carbon dioxide by new mixed sandwich uranium(III) complexes incorporating cyclooctatetraenyl and pyrrolide, phospholide, or arsolide ligands. New J. Chem., (2015), 39, 7602-7607.

Button ZE, Higgins JA, Suvova M, Cloke FG, Roe SM. Mixed sandwich thorium complexes incorporating bis(tri-isopropylsilyl)cyclooctatetraenyl and pentamethylcyclopentadienyl ligands: synthesis, structure and reactivity. Dalton Trans., (2015), 44, 2588-96.

Morgan RM, Pal M, Roe SM, Pearl LH, Prodromou C. Tah1 helix-swap dimerization prevents mixed Hsp90 co-chaperone complexes. Acta Crystallogr D Biol Crystallogr. (2015) 71 1197-206.

Trathen N, Leech MC, Crossley IR, Greenacre VK, Roe SM. Synthesis and electronic structure of the first cyaphide-alkynyl complexes. Dalton Trans. (2014) 43 9004-7.

Pal M, Morgan M, Phelps SE, Roe SM, Parry-Morris S, Downs JA, Polier S, Pearl LH, Prodromou C. Structural basis for phosphorylation-dependent recruitment of Tel2 to Hsp90 by Pih1. Structure. (2014) 22 805-18.

Kefalidis CE, Frey AS, Roe SM, Cloke FG, Maron L. Formation of cyanates in low-valent uranium chemistry: a synergistic experimental/theoretical study. Dalton Trans. (2014) 43 11202-8.

Dutton BL, Kitson RR, Parry-Morris S, Roe SM, Prodromou C, Moody CJ. Synthesis of macrolactam analogues of radicicol and their binding to heat shock protein Hsp90. Org Biomol Chem. (2014) 12 1328-40.

Gallop CW, Bobin M, Hourani P, Dwyer J, Roe SM, Viseux EM. Investigation of the reductive cleavage of BINAP and application to the rapid synthesis of phospholes. J Org Chem. (2013) 78 6522-8.

Kitson RR, Chang CH, Xiong R, Williams HE, Davis AL, Lewis W, Dehn DL, Siegel D, Roe SM, Prodromou C, Ross D, Moody CJ. Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90. Nat Chem. (2013) 5 307-14.

Bobin M, Day IJ, Roe SM, Viseux EM. Insights into the mechanism for gold catalysis: behaviour of gold(I) amide complexes in solution. Dalton Trans. (2013) 42 6592-602.

Newcombe S, Bobin M, Shrikhande A, Gallop C, Pace Y, Yong H, Gates R, Chaudhuri S, Roe SM, Hoffmann E, Viseux EME. Gold amides as anticancer drugs:synthesis and activity studies. Org. Biomol. Chem., (2013),11, 3255-3260.

Morgan RM, Hernández-Ramírez LC, Trivellin G, Zhou L, Roe SM, Korbonits M, Prodromou C. Structure of the TPR domain of AIP: lack of client protein interaction with the C-terminal α-7 helix of the TPR domain of AIP is sufficient for pituitary adenoma predisposition. PLoS One. (2012) 7 e53339.

Sharp SY, Roe SM, Kazlauskas E, Cikotienė I, Workman P, Matulis D, Prodromou C. Co-crystalization and in vitro biological characterization of 5-aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors. PLoS One. (2012) 7 :e44642.

Saunders AJ, Crossley IR, Coles MP, Roe SM. Facile self-assembly of the first diphosphametacyclophane. Chem Commun (Camb). (2012) 48 5766-8.

Day JE, Sharp SY, Rowlands MG, Aherne W, Hayes A, Raynaud FI, Lewis W, Roe SM, Prodromou C, Pearl LH, Workman P, Moody CJ. Targeting the Hsp90 molecular chaperone with novel macrolactams. Synthesis, structural, binding, and cellular studies. ACS Chem Biol. (2011) 6 1339-47.

Millson SH, Chua CS, Roe SM, Polier S, Solovieva S, Pearl LH, Sim TS, Prodromou C, Piper PW. Features of the Streptomyces hygroscopicus HtpG reveal how partial geldanamycin resistance can arise with mutation to the ATP binding pocket of a eukaryotic Hsp90. FASEB J. (2011) 25 3828-37.

Dekker C, Roe SM, McCormack EA, Beuron F, Pearl LH, Willison KR. The crystal structure of yeast CCT reveals intrinsic asymmetry of eukaryotic cytosolic chaperonins. EMBO J. (2011) 30 3078-90.

Day JE, Sharp SY, Rowlands MG, Aherne W, Lewis W, Roe SM, Prodromou C, Pearl LH, Workman P, Moody CJ. Inhibition of Hsp90 with resorcylic acid macrolactones: synthesis and binding studies. Chemistry. (2010) 16 10366-72.

Zhang Z, Roe SM, Diogon M, Kong E, El Alaoui H, Barford D. Molecular structure of the N-terminal domain of the APC/C subunit Cdc27 reveals a homo-dimeric tetratricopeptide repeat architecture. J Mol Biol. (2010) 397 1316-28.

Richards MW, Leung JW, Roe SM, Li K, Chen J, Bayliss R. A pocket on the surface of the N-terminal BRCT domain of Mcph1 is required to prevent abnormal chromosome condensation. J Mol Biol. (2010) 395 908-15.

Yang J, Zhang Z, Roe SM, Marshall CJ, Barford D. Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor. Science. (2009) 325 1398-402.

Bunney TD, Opaleye O, Roe SM, Vatter P, Baxendale RW, Walliser C, Everett KL, Josephs MB, Christow C, Rodrigues-Lima F, Gierschik P, Pearl LH, Katan M. Structural insights into formation of an active signaling complex between Rac and phospholipase C gamma 2. Mol Cell. (2009) 34 223-33.

Prodromou C, Nuttall JM, Millson SH, Roe SM, Sim TS, Tan D, Workman P, Pearl LH, Piper PW. Structural basis of the radicicol resistance displayed by a fungal hsp90. ACS Chem Biol. (2009) 4 289-97.

Parker JS, Parizotto EA, Wang M, Roe SM, Barford D. Enhancement of the seed-target recognition step in RNA silencing by a PIWI/MID domain protein. Mol Cell. (2009) 33  204-14.

Zhang MQ, Gaisser S, Nur-E-Alam M, Sheehan LS, Vousden WA, Gaitatzis N, Peck G, Coates NJ, Moss SJ, Radzom M, Foster TA, Sheridan RM, Gregory MA, Roe SM, Prodromou C, Pearl L, Boyd SM, Wilkinson B, Martin CJ. Optimizing natural products by biosynthetic engineering: discovery of nonquinone Hsp90 inhibitors. J Med Chem. (2008) 51 5494-7.

Kilkenny ML, Doré AS, Roe SM, Nestoras K, Ho JC, Watts FZ, Pearl LH. Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair. Genes Dev. (2008) 22 2034-47.

Martin CJ, Gaisser S, Challis IR, Carletti I, Wilkinson B, Gregory M, Prodromou C, Roe SM, Pearl LH, Boyd SM, Zhang MQ. Molecular characterization of macbecin as an Hsp90 inhibitor. J Med Chem. (2008) 51 2853-7.

 

Selected Older Publications:

Proisy N, Sharp SY, Boxall K, Connelly S, Roe SM, Prodromou C, Slawin AM, Pearl LH, Workman P, Moody CJ. Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol. Chem Biol. (2006) 13 1203-15.

Ali MM, Roe SM, Vaughan CK, Meyer P, Panaretou B, Piper PW, Prodromou C, Pearl LH. Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex. Nature. (2006) 440 1013-7.

Zhang M, Windheim M, Roe SM, Peggie M, Cohen P, Prodromou C, Pearl LH. Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex. Mol Cell. (2005) 20 525-38.

Parker JS, Roe SM, Barford D. Structural insights into mRNA recognition from a PIWI domain-siRNA guide complex. Nature. (2005) 434 663-6.

Parker JS, Roe SM, Barford D. Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity. EMBO J. (2004) 23 4727-37.

Roe SM, Ali MM, Meyer P, Vaughan CK, Panaretou B, Piper PW, Prodromou C, Pearl LH. The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37). Cell. (2004) 116 87-98.

Pappenberger G, Wilsher JA, Roe SM, Counsell DJ, Willison KR, Pearl LH. Crystal structure of the CCTgamma apical domain: implications for substrate binding to the eukaryotic cytosolic chaperonin. J Mol Biol. (2002) 318 1367-79.

Dajani R, Fraser E, Roe SM, Young N, Good V, Dale TC, Pearl LH. Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition. Cell. (2001) 105 721-32.

Tan TH, Edgerton SA, Kumari R, McAlister MS, Roe SM, Nagl S, Pearl LH, Selkirk ME, Bianco AE, Totty NF, Engwerda C, Gray CA, Meyer DJ. Macrophage migration inhibitory factor of the parasitic nematode Trichinella spiralis. Biochem J. (2001) 357 373-83.

Mayer SM, Lawson DM, Gormal CA, Roe SM, Smith BE. New insights into structure-function relationships in nitrogenase: A 1.6 A resolution X-ray crystallographic study of Klebsiella pneumoniae MoFe-protein. J Mol Biol. (1999) 292 871-91.

Roe SM, Prodromou C, O'Brien R, Ladbury JE, Piper PW, Pearl LH. Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin. J Med Chem. (1999) 42 260-6.

Roe SM, Barlow T, Brown T, Oram M, Keeley A, Tsaneva IR, Pearl LH. Crystal structure of an octameric RuvA-Holliday junction complex. Mol Cell. (1998) 2 361-72.

Prodromou C, Roe SM, O'Brien R, Ladbury JE, Piper PW, Pearl LH. Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone. Cell. (1997) 90 65-75.

Teeter MM, Roe SM, Heo NH. Atomic resolution (0.83 A) crystal structure of the hydrophobic protein crambin at 130 K. J Mol Biol. (1993) 230 292-311.