2023

• Sigurdsson, H. P., Hunter, H., Alcock, L., Wilson, R., Pienaar, I., Want, E., . . . Yarnall, A. J. (2023). Safety and tolerability of adjunct non-invasive vagus nerve stimulation in people with parkinson’s: a study protocol. BMC Neurology, 23(1). doi:10.1186/s12883-023-03081-1
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• Fouché, B., Turner, S., Gorham, R., Stephenson, E. J., Gutbier, S., Elson, J. L., . . . Pienaar, I. S. (2023). A Novel Mitochondria-Targeting Iron Chelator Neuroprotects Multimodally via HIF-1 Modulation Against a Mitochondrial Toxin in a Dopaminergic Cell Model of Parkinson’s Disease. Molecular Neurobiology, 60(2), 749-767. doi:10.1007/s12035-022-03107-8
  Article. View online.

2022

• Wong, J., Steyn, J. S., Pienaar, I. S., & Elson, J. L. (2022). Mitochondrial DNA population variation is not associated with Alzheimer’s in the Japanese population: A consistent finding across global populations. PLoS ONE, 17(10 October). doi:10.1371/journal.pone.0276169
  Article. View online.
• Müller-Nedebock, A. C., Pfaff, A. L., Pienaar, I. S., Kõks, S., van der Westhuizen, F. H., Elson, J. L., & Bardien, S. (2022). Mitochondrial DNA variation in Parkinson’s disease: Analysis of “out-of-place” population variants as a risk factor. Frontiers in Aging Neuroscience, 14. doi:10.3389/fnagi.2022.921412
  Article. View online.
• Lewis, F. W., Bird, K., Navarro, J. P., El Fallah, R., Brandel, J., Hubscher-Bruder, V., . . . Pienaar, I. S. (2022). Synthesis, physicochemical characterization and neuroprotective evaluation of novel 1-hydroxypyrazin-2(1 H)-one iron chelators in an in vitro cell model of Parkinson's disease. Dalton Transactions, 51(9), 3590-3603. doi:10.1039/d1dt02604f
  Article. View online.

2021

• Bailey, L., Elson, J. L., & Pienaar, I. (2021). Single-cell approaches for studying the role of mitochondrial DNA in neurodegenerative disease. Methods in Molecular Biology, 2277, 299-329. doi:10.1007/978-1-0716-1270-5_19
  Article. View on figshare.
• Pienaar, I., Mohammed, R., Courtley, R., Gledson, M. R., Reynolds, R., Nicholas, R., & Elson, J. L. (2021). Investigation of the correlation between mildly deleterious mtDNA variations and the clinical progression of multiple sclerosis. Multiple Sclerosis and Related Disorders, 53, pages. doi:10.1016/j.msard.2021.103055
  Article. View on figshare.

2020

• Mantanona, C. P., Božic, T., Chudasama, Y., Robbins, T. W., Dalley, J. W., Alsiö, J., & Pienaar, I. (n.d.). Dissociable contributions of mediodorsal and anterior thalamic nuclei in visual attentional performance: a comparison using nicotinic and muscarinic cholinergic receptor antagonists. Journal of Psychopharmacology, 1-11. doi:10.1177/0269881120965880
  Article. View on figshare.
• Gutbier, S., Kyriakou, S., Schildknecht, S., Ückert, A. -K., Brüll, M., Lewis, F., . . . Pienaar, I. (n.d.). Design and evaluation of bi-functional iron chelators for protection of dopaminergic neurons from toxicants. Archives of Toxicology, pages. doi:10.1007/s00204-020-02826-y
  Article. View on figshare.
• Lewis, F. W., Fairooz, S., Elson, J. L., Hubscher-Bruder, V., Brandel, J., Soundararajan, M., . . . Pienaar, I. (2020). Novel 1-hydroxypyridin-2-one metal chelators prevent and res-cue ubiquitin proteasomal-related neuronal injury in an in vitro model of Parkinson’s disease. Archives of Toxicology, 1-19. doi:10.1007/s00204-020-02672-y
  Article. View on figshare.
• Sharma, P. K., Wells, L., Rizzo, G., Elson, J. L., Passchier, J., Rabiner, E. A., . . . Pienaar, I. (2020). DREADD activation of pedunculopontine cholinergic neurons reverses motor deficits and restores striatal dopamine signaling in parkinsonian rats. Neurotherapeutics, pages. doi:10.1007/s13311-019-00830-4
  Article. View on figshare.

2019

• Mantanona, C. P., Alsiö, J., Elson, J. L., Fisher, B. M., Dalley, J. W., Bussey, T., & Pienaar, I. (n.d.). Altered motor, anxiety-related and attentional task performance at baseline associate with multiple gene copies of the vesicular acetylcholine transporter and related protein overexpression in ChAT::Cre+ rats. Brain Structure and Function, 3095-3116. doi:10.1007/s00429-019-01957-y
  Article. View on figshare.
• Thubron, E. B., Rosa, H. S., Hodges, A., Sivaprasad, S., Francis, P. T., Pienaar, I., & Malik, A. N. (2019). Regional mitochondrial DNA and cell-type changes in post-mortem brains of non-diabetic Alzheimer’s disease are not present in diabetic Alzheimer’s disease. Scientific Reports, 9(1), pages. doi:10.1038/s41598-019-47783-4
  Article. View on figshare.
• Müller-Nedebock, A. C., Brennan, R. R., Venter, M., Pienaar, I., van der Westhuizen, F. H., Elson, J. L., . . . Bardien, S. (n.d.). The unresolved role of mitochondrial DNA in Parkinson’s disease: an overview of published studies, their limitations, and future prospects. Neurochemistry International, pages. doi:10.1016/j.neuint.2019.104495
  Article. View on figshare.
• Venter, M., Tomas, C., Pienaar, I., Strassheim, V., Erasmus, E., Ng, W. -F., . . . Elson, J. L. (n.d.). MtDNA population variation in Myalgic encephalomyelitis/Chronic fatigue syndrome in two populations: a study of mildly deleterious variants. Scientific Reports, 9(2914), 1-8. doi:10.1038/s41598-019-39060-1
  Article. View on figshare.

2018

• Sharma, P., & Pienaar, I. (2018). The use of DREADDs for dissecting the contribution of cellular and neural circuit mechanisms in models of neurodegenerative disease. In Molecular-genetic and statistical techniques for behavioral and neural research (pp. 708.0 pages). New York: Academic Press.
  Chapter. View on figshare.
• Kay, L., Pienaar, I., Cooray, R., & Soundararajan, M. (2018). Understanding miro GTPases: implications in the treatment of neurodegenerative disorders. Molecular Neurobiology, 55(9), 7352-7365. doi:10.1007/s12035-018-0927-x
  Article. View on figshare.

2017

• Elson, J. L., Kochaj, R., Reynolds, R., & Pienaar, I. (2018). Temporal-spatial profiling of pedunculopontine galanin-cholinergic neurons in the lactacystin rat model of Parkinson’s disease. Neurotoxicity Research, 34(1), 16-31. doi:10.1007/s12640-017-9846-2
  Article. View on figshare.
• Bury, A. G., Pyle, A., Elson, J. L., Greaves, L., Morris, C. M., Hudson, G., & Pienaar, I. (n.d.). Mitochondrial DNA changes in pedunculopontine cholinergic neurons in Parkinson’s disease. Annals of Neurology, 82(6), 1016-1021. doi:10.1002/ana.25099
  Article. View on figshare.
• Pienaar, I., Howell, N., & Elson, J. L. (2017). MutPred mutational load analysis shows mildly deleterious mitochondrial DNA variants are not more prevalent in Alzheimer's patients, but may be under-represented in healthy older individuals. Mitochondrion, 34, 141-146. doi:10.1016/j.mito.2017.04.002
  Article. View on figshare.

2016

• Gillies, G. E., Virdee, K., Pienaar, I., Al-Zaid, F., & Dalley, J. W. (n.d.). Enduring, sexually dimorphic impact of in utero exposure to elevated levels of glucocorticoids on midbrain dopaminergic populations. Brain Sciences, 7(5), 1-29. doi:10.3390/brainsci7010005
  Article. View on figshare.
• Pienaar, I., Vernon, A., & Winn, P. (2017). The cellular diversity of the pedunculopontine nucleus: relevance to behavior in health and aspects of Parkinson's disease. Neuroscientist, 23(4), 415-431. doi:10.1177/1073858416682471
  Article. View on figshare.
• McArthur, S., Pienaar, I. S., Siddiqi, S. M., & Gillies, G. E. (2016). Sex-specific disruption of murine midbrain astrocytic and dopaminergic developmental trajectories following antenatal GC treatment. Brain Structure and Function, 221(5), 2459-2475. doi:10.1007/s00429-015-1049-0
  Article. View online.

2015

• Pienaar, I., Gartside, S. E., Sharma, P., De Paola, V., Gretenkord, S., Withers, D., . . . Dexter, D. T. (2015). Pharmacogenetic stimulation of cholinergic pedunculopontine neurons reverses motor deficits in a rat model of Parkinson’s disease. Molecular Neurodegeneration, 10(1), 1-22. doi:10.1186/s13024-015-0044-5
  Article. View on figshare.
• Goode, A. E., Carter, D. A. G., Motskin, M., Pienaar, I., Chen, S., Hu, S., . . . Porter, A. E. (n.d.). High resolution and dynamic imaging of biopersistence and bioreactivity of extra and intracellular MWNTs exposed to microglial cells. Biomaterials, 70, 57-70. doi:10.1016/j.biomaterials.2015.08.019
  Article. View on figshare.
• Elson, J. L., Yates, A., & Pienaar, I. (2016). Pedunculopontine cell loss and protein aggregation direct microglia activation in parkinsonian rats. Brain Structure and Function, 221(4), 2319-2341. doi:10.1007/s00429-015-1045-4
  Article. View on figshare.
• Geldenhuys, W. J., Guseman, T. L., Pienaar, I. S., Dluzen, D. E., & Young, J. W. (2015). A novel biomechanical analysis of gait changes in the MPTP mouse model of Parkinson's disease. PeerJ, 2015(8). doi:10.7717/peerj.1175
  Article. View online.
• Pienaar, I. S., Harrison, I. F., Elson, J. L., Bury, A., Woll, P., Simon, A. K., & Dexter, D. T. (2015). An animal model mimicking pedunculopontine nucleus cholinergic degeneration in Parkinson’s disease. Brain Structure and Function, 220(1), 479-500. doi:10.1007/s00429-013-0669-5
  Article. View online.
• Pienaar, I. S., Dexter, D. T., & Gradinaru, V. (2015). Neurophysiological and Optogenetic Assessment of Brain Networks Involved in Motor Control. In Movement Disorders: Genetics and Models: Second Edition (pp. 187-199). doi:10.1016/B978-0-12-405195-9.00011-1
  Chapter. View online.

2014

• Pienaar, I., Lee, C. H., Elson, J. L., McGuinness, L., Gentleman, S. M., Kalaria, R. N., & Dexter, D. T. (2015). Deep-brain stimulation associates with improved microvascular integrity in the subthalamic nucleus in Parkinson's disease. Neurobiology of Disease, 74, 392-405. doi:10.1016/j.nbd.2014.12.006
  Article. View on figshare.
• Sharma, P., & Pienaar, I. S. (2014). Pharmacogenetic and optical dissection for mechanistic understanding of Parkinson's disease: Potential utilities revealed through behavioural assessment. Neuroscience and Biobehavioral Reviews, 47, 87-100. doi:10.1016/j.neubiorev.2014.07.026
  Article. View online.
• Lee, H., & Pienaar, I. S. (2014). Disruption of the blood-brain barrier in parkinson's disease: Curse or route to a cure?. Frontiers in Bioscience - Landmark, 19(2), 272-280. doi:10.2741/4206
  Article. View online.
• Gillies, G. E., Pienaar, I. S., Vohra, S., & Qamhawi, Z. (2014). Sex differences in Parkinson's disease. Frontiers in Neuroendocrinology, 35(3), 370-384. doi:10.1016/j.yfrne.2014.02.002
  Article. View online.

2013

• Pienaar, I. S., Elson, J. L., Racca, C., Nelson, G., Turnbull, D. M., & Morris, C. M. (2013). Mitochondrial abnormality associates with type-specific neuronal loss and cell morphology changes in the pedunculopontine nucleus in Parkinson disease. American Journal of Pathology, 183(6), 1826-1840. doi:10.1016/j.ajpath.2013.09.002
  Article. View online.
• Pienaar, I. S., & van de Berg, W. (2013). A non-cholinergic neuronal loss in the pedunculopontine nucleus of toxin-evoked Parkinsonian rats. Experimental Neurology, 248, 213-223. doi:10.1016/j.expneurol.2013.06.008
  Article. View online.
• Bury, A., & Pienaar, I. S. (2013). Behavioral testing regimens in genetic-based animal models of Parkinson's disease: Cogencies and caveats. Neuroscience and Biobehavioral Reviews, 37(5), 846-859. doi:10.1016/j.neubiorev.2013.03.007
  Article. View online.
• Pienaar, I. S., & Chinnery, P. F. (2013). Existing and emerging mitochondrial-targeting therapies for altering Parkinson's disease severity and progression. Pharmacology and Therapeutics, 137(1), 1-21. doi:10.1016/j.pharmthera.2012.08.010
  Article. View online.

2012

• Proctor, C. J., Pienaar, I., Elson, J. L., & Kirkwood, T. B. L. (2012). Aggregation, impaired degradation and immunization targeting of amyloid-beta dimers in Alzheimer’s disease: a stochastic modelling approach. Molecular Neurodegeneration, 7, 1-17. doi:10.1186/1750-1326-7-32
  Article. View on figshare.
• Lax, N. Z., Pienaar, I. S., Reeve, A. K., Hepplewhite, P. D., Jaros, E., Taylor, R. W., . . . Turnbull, D. M. (2012). Microangiopathy in the cerebellum of patients with mitochondrial DNA disease. Brain, 135(6), 1736-1750. doi:10.1093/brain/aws110
  Article. View online.
• Pienaar, I. S., Burn, D., Morris, C., & Dexter, D. (2012). Synaptic protein alterations in Parkinson's disease. Molecular Neurobiology, 45(1), 126-143. doi:10.1007/s12035-011-8226-9
  Article. View online.
• Pienaar, I. S., Lu, B., & Schallert, T. (2012). Closing the gap between clinic and cage: Sensori-motor and cognitive behavioural testing regimens in neurotoxin-induced animal models of Parkinson's disease. Neuroscience and Biobehavioral Reviews, 36(10), 2305-2324. doi:10.1016/j.neubiorev.2012.07.009
  Article. View online.

2010

• Pienaar, I. S., Götz, J., & Feany, M. B. (2010). Parkinson's disease: Insights from non-traditional model organisms. Progress in Neurobiology, 92(4), 558-571. doi:10.1016/j.pneurobio.2010.09.001
  Article. View online.
• Sattelle, D. B., Buckingham, S. D., Akamatsu, M., Matsuda, K., Pienaar, I. S., Jones, A. K., . . . Blundell, C. D. (2010). Corrigendum to "Comparative pharmacology and computational modelling yield insights into allosteric modulation of human α7 nicotinic acetylcholine receptors" [Biochem. Pharmacol. 78 (2009) 836-843] (DOI:10.1016/j.bcp.2009.06.020). Biochemical Pharmacology, 79(9), 1372. doi:10.1016/j.bcp.2010.01.011
  Article. View online.
• Pienaar, I. S., Dexter, D. T., & Burkhard, P. R. (2010). Mitochondrial proteomics as a selective tool for unraveling Parkinsons disease pathogenesis. Expert Review of Proteomics, 7(2), 205-226. doi:10.1586/epr.10.8
  Article. View online.
• Threlfell, S., Clements, M. A., Khodai, T., Pienaar, I. S., Exley, R., Wess, J., & Cragg, S. J. (2010). Striatal muscarinic receptors promote activity dependence of dopamine transmission via distinct receptor subtypes on cholinergic interneurons in ventral versus dorsal striatum. Journal of Neuroscience, 30(9), 3398-3408. doi:10.1523/JNEUROSCI.5620-09.2010
  Article. View online.

2009

• Pienaar, I. S., Schallert, T., Hattingh, S., & Daniels, W. M. U. (2009). Erratum: Behavioral and quantitative mitochondrial proteome analyses of the effects of simvastatin: Implications for models of neural degeneration(Journal of Neural Transmission (2009) 116 (791-806) DOI: 10.1007/s00702-009-0247-4). Journal of Neural Transmission, 116(10), 1349. doi:10.1007/s00702-009-0280-3
  Article. View online.
• Sattelle, D. B., Buckingham, S. D., Akamatsu, M., Matsuda, K., Pienaar, I., Jones, A. K., . . . Blundell, C. D. (2009). Comparative pharmacology and computational modelling yield insights into allosteric modulation of human α7 nicotinic acetylcholine receptors. Biochemical Pharmacology, 78(7), 836-843. doi:10.1016/j.bcp.2009.06.020
  Article. View online.
• Pienaar, I. S., Schallert, T., Hattingh, S., & Daniels, W. M. U. (2009). Behavioral and quantitative mitochondrial proteome analyses of the effects of simvastatin: Implications for models of neural degeneration. Journal of Neural Transmission, 116(7), 791-806. doi:10.1007/s00702-009-0247-4
  Article. View online.

2008

• Pienaar, I. S., Kellaway, L. A., Russell, V. A., Smith, A. D., Stein, D. J., Zigmond, M. J., & Daniels, W. M. U. (2008). Maternal separation exaggerates the toxic effects of 6-hydroxydopamine in rats: Implications for neurodegenerative disorders. Stress, 11(6), 448-456. doi:10.1080/10253890801890721
  Article. View online.
• Pienaar, I. S., Daniels, W. M. U., & Götz, J. (2008). Neuroproteomics as a promising tool in Parkinson's disease research. Journal of Neural Transmission, 115(10), 1413-1430. doi:10.1007/s00702-008-0070-3
  Article. View online.

2007

• Pienaar, I. S., Schallert, T., Russell, V. A., Kellaway, L. A., Carr, J. A., & Daniels, W. M. U. (2007). Early pubertal female rats are more resistant than males to 6-hydroxydopamine neurotoxicity and behavioural deficits: A possible role for trophic factors. Restorative Neurology and Neuroscience, 25(5-6), 513-526.
  Article.