Client Protein activation by the Hsp90 Molecular Chaperone System
Protein kinase recruitment and activation by the HSP90-CDC37 system - funded by The Wellcome Trust
We are studying the structural and mechanistic basis for recruitment and activation of eukaryotic protein kinases by the HSP90-CDC37 system, using a combination of biochemical, bipohysical and structural techniques.
PIKK recruitment and activation by the R2TP-TTT system - funded by BBSRC
We are studying the structural and mechanistic basis for recruitment and activation of phoshatidylinositol kinase-like kinases (PIKKs) by the R2TP and TTT systems, using a combination of biochemical, bipohysical and structural techniques.