Publications

 

Logo

  

Original research

  • Hubin EA, Tabib-Salazar A, Humphrey LJ, Flack JE, Olinares PD, Darst SA, Campbell EA, Paget MS. (2015) Structural, functional, and genetic analyses of the actinobacterial transcription factor RbpA. Proc Natl Acad Sci U S A. 112:7171-6.
  • Tabib-Salazar A, Liu B, Doughty P, Lewis RA, Ghosh S, Parsy ML, Simpson PJ, O'Dwyer K, Matthews SJ, Paget MS. (2013) The actinobacterial transcription factor RbpA binds to the principal sigma subunit of RNA polymerase. Nucleic Acids Res. 41: 5679-91 
  • *McLaughlin KJ, *Strain-Damerell CM, Xie K, Brekasis D, Soares AS, Paget MS and Kielkopf CL (2010) Structural Basis for NADH/NAD+ Redox Sensing by a Rex-Family Repressor. Mol Cell 38: 563-75 [* these authors contributed equally to the work] .
  • Kallifidas D, Thomas D, Doughty P & Paget MS (2010) The SigR regulon of Streptomyces coelicolor A3(2) reveals a key role in protein quality control during disulphide stress. Microbiology 156: 1661-72.
  • Kallifidas D, Pascoe B, Owen GA, Strain-Damerell CM, Hong HJ & Paget MS (2010). The zinc-responsive regulator Zur controls expression of the coelibactin gene cluster in Streptomyces coelicolor. J Bacteriol. 192: 608-11.
  • Owen GA, Pascoe B,  Kallifidas, D & Paget MS (2007)  Zinc-responsive regulation of alternative ribosomal protein genes in Streptomyces coelicolor involves Zur and SigR.    J Bacteriol  189: 4078-86.
  • Zdanowski K, Doughty P, Jakimowicz P, O'Hara L, Buttner MJ, Paget MS & Kleanthous C  (2006) Assignment of the zinc ligands in RsrA, a redox-sensing ZAS protein from Streptomyces coelicolor. Biochemistry 45: 8294-300.
  • Newell KV, Thomas DP, Brekasis D &  Paget MS (2006) The RNA polymerase-binding protein RbpA confers basal levels of rifampicin resistance on Streptomyces coelicolor. Mol Microbiol. 60: 687-96.
  • Sickmier EA, Brekasis D, Paranawithana S, Bonanno JB, Paget MS, Burley SK & Kielkopf CL (2005) X-ray structure of a Rex-family repressor/NADH complex – insights into the mechanism of redox sensing. Structure 13: 43-54.
  • Hong H-J, Hutchings MI, NeuJM, Wright GD, Paget MS, & Buttner MJ (2004) Characterisation of an inducible vancomycin resistance system in Streptomyces coelicolor: a novel gene (vanK) is required for drug resistance. Mol Microbiol 52: 1107-1121.
  • Li W, Bottrill AR, Bibb MJ, Buttner MJ, Paget MS & Kleanthous C (2003) The Role of Zinc in the Disulfide Stress-Regulated Anti-Sigma Factor RsrA from Streptomyces coelicolor J Mol Biol 333: 461-472.
  • Brekasis D & Paget MS (2003) A novel sensor of NADH/NAD+ redox poise in Streptomyces coelicolor A3(2). EMBO J 22: 4856-486.
  • Li W, Stevenson CE, Burton N, Jakimowicz P, Paget MS, Buttner MJ, Lawson, DM & Kleanthous C (2002) Identification and structure of the anti-sigma factor-binding domain of the disulphide-stress regulated sigma factor SigR from Streptomyces coelicolor. J Mol Biol 323: 225-236.
  • Hong H-J, Paget MS, and Buttner MJ (2002) A signal transduction system in Streptomyces coelicolor that activates expression of a putative cell wall glycan operon in response to vancomycin and other cell wall-specific antibiotics. Mol Microbiol 44: 1199-1211.
  • Paget MS, Molle V, Cohen G, Aharonowitz Y, &  Buttner MJ (2001) Defining the disulphide stress response in Streptomyces coelicolor A3(2): identification of the SigR regulon. Mol Microbiol 42: 1007-1020.
  • Paget MS, Bae J-B, Hahn M-Y, Wei L, Kleanthous C, Roe J-H &  Buttner MJ (2001) Mutational analysis of RsrA, a zinc-binding anti-sigma factor with a thiol-disulphide redox switch. Mol Microbiol 39: 1036-1047.
  • Kang JG, Paget MS, Seok Y-J, Hahn M-Y, Bae J-B, Kleanthous C, Buttner MJ, & Roe J-H (1999) RsrA, an anti-sigma factor regulated by redox change. EMBO J 18: 4292-4298.
  • Paget MS, Leibovitz E, & Buttner MJ (1999) A putative two-component signal transduction system regulates σE, a sigma factor required for cell wall integrity in Streptomyces coelicolor A3(2). Mol. Microbiol. 33: 97-107.
  • Paget MS, Chamberlin L,  Atrih A, Foster SJ, & Buttner MJ (1999) Evidence that the extracytoplasmic function sigma factor, SigE, is required for normal cell wall structure in Streptomyces coelicolor A3(2).  J. Bacteriol 181: 204-211.
  • Paget MS, Kang J-G, Roe, J-H., & Buttner MJ (1998) SigR, an RNA polymerase sigma factor that modulates expression of the thioredoxin system in response to oxidative stress in Streptomyces coelicolor A3(2). EMBO J. 17: 5776-5782.
  • Jones GH, Paget MS, Chamberlin L, and Buttner MJ (1997) Sigma-E is required for the production of the antibiotic actinomycin in Streptomyces antibioticus. Mol. Microbiol. 23: 169-178.
  • Paget MS, Hintermann G, & Smith CP (1994) Construction and application of streptomycete promoter probe vectors which employ the Streptomyces glaucescens tyrosinase-encoding gene as reporter. Gene 146: 105-110.

  Reviews

  • Paget MS (2015) Bacterial Sigma Factors and Anti-Sigma Factors: Structure, Function and Distribution. Biomolecules 5, 1245-1265.
  • Paget, MS (2014) Prokaryotic Gene Regulation by Sigma Factors and RNA Polymerase. In Molecular Life Sciences SE  - 36-3. Bell, E. (ed.). Springer New York, pp. 1–7.
  • Green J & Paget MS (2004) Bacterial redox sensors. Nat Rev Microbiol. 2: 954-66.
  • Paget MS & Buttner MJ (2003) Thiol-disulphide redox switches. Ann Rev Genet 37: 91-121.
  • Paget MS & Helmann JD (2003) The Sig70 family of sigma factors. Genome Biology 4: 203.
  • Hong H-J, Paget MS, Hutchings M, Leibovitz E, and Buttner MJ (2002)  Sensing and responding to cell envelope stress in Streptomyces coelicolor.  Actinomycetologica 16: 41-47.
  • Paget MS, Hong H-J, Bibb MJ, &  Buttner MJ (2002) The ECF sigma factors of Streptomyces coelicolor A3(2). In SGM symposium 61: Signals, switches, regulons and cascades: control of bacterial gene expression Ed D.A. Hodgson and C.M. Thomas. Cambridge University Press.