Publications

Professor Anthony Moore

 

Carre, J.E., Affourtit, C. & Moore, A.L. (2011) FEBS Lett 585, 397-401 “Interaction of purified plant alternative oxidase from Arum maculatum with pyruvate

Albury, M.A., Elliott, C. & Moore, A.L. (2010) Biochim. Biophys. Acta 1797 1933–1939 “Ubiquinol-binding site in the alternative oxidase: Mutagenesis reveals features important for substrate binding and inhibition

El-Kadi, A. M., Bros, V., Deng, W., Stoddart, E., Banks, G., Jackson, G., Fisher, E.M.C Duchen,  M., Greensmith, L., Moore, A.L. Hafezparast M. (2010) J. Biol. Chem 285, 18627-18639 “The legs at odd angles (loa) mutation in cytoplasmic dynein ameliorates mitochondrial function in sod1g93a mice.

Crichton P.G., Albury M.S., Affourtit, C. &. Moore A.L. (2010) Biochim. Biophys. Acta 1797, 732-737. “Mutagenesis of the plant alternative oxidase reveals features important features for oxygen binding and catalysis.”

Kido, Y., Sakamoto, K., Nakamura, K., Harada, M., Suzuki, T., Yabu, Y., Saimoto, H., Yamakura, F., Ohmori, D., Moore, A., Harada, S. & Kita, K. (2010) Biochim. Biophys. Acta 1797, 443-450. “Purification and kinetic characterisation of recombinant alternative oxidase from Trypanosoma brucei brucei”

Kido, Y., Shiba, T., Inaoka, D.K., Sakamoto, K., Nara, T., Aoki, T., Honma, T., Tanaka, A., Inoue, M., Matsuoka, S., Moore, A., Harada, S. & Kita, K. (2010) Acta. Crystallogr. Sect. F Struct. Biol. Cryst. Commun., 66, 275-278 “Crystallization and preliminary crystallographic analysis of cyanide-insensitive alternative oxidase from Trypanosoma brucei brucei

Williams B.A.P., Elliot C., Burri L., Kido Y., Kita K., Moore A.L. And Keeling P. J. (2010) Plos Pathogens 6: 2 e1000761 “Wide distribution of the mitochondrial alternative oxidase in microsporidia parasites

Albury, M.S., Elliott, C. & Moore, A.L. (2009) Physiol. Plantarum 137, 316-327 “Towards a structural elucidation of the alternative oxidase in plants”

Maréchal, A, Kido, Y., Kita K., Moore A.L. & Rich P.R. (2009) J. Biol. Chem. 284, 31827-31833 “Identification of three redox states of recombinant Trypanosoma brucei alternative oxidase by FTIR spectroscopy and electrochemistry

Moore, A.L. & Albury M.A. (2008) Biochem Soc Trans 36, 1022–1026 “Further insights into the structure of the alternative oxidase: from plants to parasites”

Wagner A.M., Krab, Wagner M.J., & Moore A.L. (2008) Biochim Biophys. Acta 1777, 993–1000 “Regulation of thermogenesis in flowering Araceae: The role of the alternative oxidase”

Article

Szibor, Marten, Schenkl, Christina, Barsottini, Mario R O, Young, Luke and Moore, Anthony L (2022) Targeting the alternative oxidase (AOX) for human health and food security, a pharmaceutical and agrochemical target or a rescue mechanism? Biochemical Journal, 479 (12). pp. 1337-1359. ISSN 0264-6021

Rubbiani, Riccardo, Weil, Tobias, Tocci, Noemi, Mastrobuoni, Luciano, Jeger, Severin, Moretto, Marco, Ng, James, Lin, Yan, Hess, Jeannine, Ferrari, Stefano, Kaech, Andres, Young, Luke, Spencer, John, Moore, Anthony L and others, (2021) In vivo active organometallic-containing antimycotic agents. RSC Chemical Biology, 2 (4). pp. 1263-1273. ISSN 2633-0679

Copsey, Alice C, Barsottini, Mario R O, May, Benjamin, Xu, Fei, Albury, Mary S, Young, Luke and Moore, Anthony L (2021) Kinetic characterisation and inhibitor sensitivity of Candida albicans and Candida auris recombinant AOX expressed in a self-assembled proteoliposome system. Scientific Reports, 11. a14748 1-10. ISSN 2045-2322

Young, Luke, Rosell-Hidalgo, Alicia, Inaoka, Daniel Ken, Xu, Fei, Albury, Mary, May, Benjamin, Kita, Kiyoshi and Moore, Anthony L (2020) Kinetic and structural characterisation of the ubiquinol-binding site and oxygen reduction by the trypanosomal alternative oxidase. BBA - Bioenergetics, 1861 (10). a148247. ISSN 0005-2728

Szibor, Marten, Gainutdinov, Timur, Fernandez-Vizarra, Erika, Dufour, Eric, Gizatullina, Zemfira, Debska-Vielhaber, Grazyna, Heidler, Juliana, Wittig, Ilka, Viscomi, Carlo, Gellerich, Frank and Moore, Anthony L (2019) Bioenergetic consequences from xenotopic expression of a tunicate AOX in mouse mitochondria: switch from RET and ROS to FET. BBA - Bioenergetics. p. 148137. ISSN 0005-2728

Balogun, Emmanuel Oluwadare, Inaoka, Daniel Ken, Shiba, Tomoo, Tsuge, Chiaki, May, Benjamin, Sato, Tomohiro, Kido, Yasutoshi, Nara, Takeshi, Aoki, Takashi, Honma, Teruki, Tanaka, Akiko, Inoue, Masayuki, Matsuoka, Shigeru, Michels, Paul A M, Watanabe, Yoh-Ichi, Moore, Anthony L, Harada, Shigeharu and Kita, Kiyoshi (2019) Discovery of trypanocidal coumarins with dual inhibition of both the glycerol kinase and alternative oxidase of Trypanosoma brucei brucei. FASEB Journal, 33 (11). pp. 13002-13013. ISSN 0892-6638

O’Reilly, Molly, Young, Luke, Kirkwood, Nerissa K, Richardson, Guy P, Kros, Corné J and Moore, Anthony L (2019) Gentamicin affects the bioenergetics of isolated mitochondria and collapses the mitochondrial membrane potential in cochlear sensory hair cells. Frontiers in Cellular Neuroscience, 13 (a416). pp. 1-12. ISSN 1662-5102

Shiba, Tomoo, Inaoka, Daniel Ken, Takahashia, Gen, Tsuge, Chiaka, Kido, Yasutoshi, Young, Luke, Ueda, Satoshi, Baloguna, Emmanuel Oluwadare, Narah, Takeshi, Honma, Teruki, Tanaka, Akiko, Inoue, Masayuki, Saimoto, Hiroyuki, Harada, Shigeharu, Moore, Anthony L and Kita, Kiyoshi (2019) Insights into the ubiquinol/dioxygen binding and proton relay pathways of the alternative oxidase. BBA - Bioenergetics, 1860 (5). pp. 375-382. ISSN 0005-2728

Tsaousis, Anastasios D, Hamblin, Karleigh A, Elliott, Kate, Young, Luke, Rosell Hidalgo, Alicia, Gourlay, Campbell W, Moore, Anthony and van der Giezen, Mark (2018) The human gut colonizer blastocystis respires using complex II and alternative oxidase to buffer transient oxygen fluctuations in the gut. Frontiers in Cellular and Infection Microbiology, 8 (371). pp. 1-11. ISSN 2235-2988

Miyazaki, Yuki, Inaoka, Daniel, Shiba, Tomoo, Saimoto, Hiroyuki, Sakura, Takaya, Amalia, Eri, Kido, Yasutoshi, Sakai, Chika, Nakamura, Mari, Moore, Anthony, Harada, Shigeharu and Kita, Kiyoshi (2018) Selective cytotoxicity of dihydroorotate dehydrogenase inhibitors to human cancer cells under hypoxia and nutrient-deprived conditions. Frontiers in Pharmacology, 9 (997). pp. 1-13. ISSN 1663-9812

May, Benjamin, Young, Luke and Moore, Anthony L (2017) Structural insights into the alternative oxidases: are all oxidases made equal? Biochemical Society Transactions, 45 (3). pp. 731-740. ISSN 0300-5127

Jones, Andrew J Y, Blaza, James N, Bridges, Hannah R, May, Benjamin, Moore, Anthony L and Hirst, Judy (2016) A self-assembled respiratory chain that catalyzes NADH oxidation by ubiquinone-10 cycling between complex I and the alternative oxidase. Angewandte Chemie International Edition, 55 (2). pp. 728-731. ISSN 1433-7851

Elliott, Kate, Young, Luke, May, Ben, Shearman, Julia, Albury, Mary S, Kido, Yasutoshi, Kita, Kiyoshi and Moore, Anthony L (2014) Purification and characterisation of recombinant DNA encoding the alternative oxidase from Sauromatum guttatum. Mitochondrion, 19 (Part B). pp. 261-268. ISSN 1567-7249

Young, Luke, May, Benjamin, Pendlebury-Watt, Alice, Shearman, Julia, Elliott, Kate, Albury, Mary S, Shiba, Tomoo, Inaoka, Daniel Ken, Harada, Shigeharu, Kita, Kiyoshi and Moore, Anthony L (2014) Probing the ubiquinol-binding site of recombinant Sauromatum guttatum alternative oxidase expressed in E. coli membranes through site-directed mutagenesis. BBA - Biochimica et Biophysica Acta, 1837 (7). pp. 1219-1225. ISSN 0006-3002

Shiba, Tomoo, Kido, Yasutoshi, Sakamoto, Kimitoshi, Inaoka, Daniel Ken, Tsuge, Chiaki, Tatsumi, Ryoko, Balogun, Emmanuel Oluwarade, Nara, Takeshi, Aoki, Takashi, Honma, Teruki, Tanaka, Akiko, Inoue, Masayuki, Matsuoka, Shigeru, Saimoto, Hiroyuki, Moore, Anthony L., Harada, Shigeharu and Kita, Kiyoshi (2013) Structure of the trypanosome cyanide-insensitive alternative oxidase. Proceedings of the National Academy of Sciences of the United States of America, 110 (12). pp. 4580-4585. ISSN 1091-6490

Kakizaki, Yusuke, Moore, Anthony L and Ito, Kikukatsu (2012) Different molecular bases underlie the mitochondrial respiratory activity in the homoeothermic spadices of Symplocarpus renifolius and the transiently thermogenic appendices of Arum maculatum. The Biochemical Journal, 445 (2). pp. 237-246. ISSN 1470-8728

Moore, A, Affourtit, C and Carré, J (2011) Interaction of purified plant alternative oxidase from Arum maculatum with pyruvate. FEBS Letters, 585 (2). pp. 397-401. ISSN 0014-5793

Albury, Mary S, Elliott, Catherine and Moore, Anthony L (2010) Ubiquinol-binding site in the alternative oxidase: mutagenesis reveals features important for substrate binding and inhibition. BBA - Bioenergetics, 1797 (12). pp. 1933-9. ISSN 0005-2728

Crichton, Paul G, Albury, Mary S, Affourtit, Charles and Moore, Anthony L (2010) Mutagenesis of the Sauromatum guttatum alternative oxidase reveals features important for oxygen binding and catalysis. BBA - Bioenergetics, 1797 (6-7). pp. 732-737. ISSN 0005-2728

Morsi el Kadi, Ali, Bros-Facer, Virginie, Deng, Wenhan, Philpott, Amelia, Stoddart, Eleanor, Banks, Gareth, Jackson, Graham S, Fisher, Elizabeth M C, Duchen, Michael R, Greensmith, Linda, Moore, Anthony L and Hafezparast, Majid (2010) The Legs at odd angles (Loa) mutation in cytoplasmic dynein ameliorates mitochondrial function in SOD1G93A mouse model for motor neuron disease. Journal of Biological Chemistry, 285 (24). pp. 18627-18639. ISSN 1083-351X

Kido, Yasutoshi, Sakamoto, Kimitoshi, Nakamura, Kosuke, Harada, Michiyo, Suzuki, Takashi, Yabu, Yoshisada, Saimoto, Hiroyuki, Yamakura, Fumiyuki, Ohmori, Daijiro, Moore, Anthony, Harada, Shigeharu and Kita, Kiyoshi (2010) Purification and kinetic characterisation of recombinant alternative oxidase from Trypanosoma brucei brucei. BBA - Bioenergetics, 1797 (4). pp. 443-450. ISSN 0005-2728

Kido, Yasutoshi, Shiba, Tomoo, Inaoka, Daniel Ken, Sakamoto, Kimitoshi, Nara, Takeshi, Aoki, Takashi, Honma, Teruki, Tanaka, Akiko, Inoue, Masayuki, Matsuoka, Shigeru, Moore, Anthony, Haradaf, Shigeharu and Kita, Kiyoshi (2010) Crystallization and preliminary crystallographic analysis of cyanide-insensitive alternative oxidase from Trypanosoma brucei brucei. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 66 (3). pp. 275-278. ISSN 1744-3091

Williams, Bryony A P, Elliott, Catherine, Burri, Lena, Kido, Yasutoshi, Kita, Kiyoshi, Moore, Anthony L and Keeling, Patrick J (2010) A broad distribution of the alternative oxidase in microsporidian parasites. PLoS Pathogens, 6 (2). e1000761. ISSN 1553-7366

Albury, Mary S, Elliott, Catherine and Moore, Anthony L (2009) Towards a structural elucidation of the alternative oxidase in plants. Physiologia Plantarum, 137 (4). pp. 316-327. ISSN 0031-9317

Marechal, Amandine, Kido, Yasutoshi, Kita, Kiyoshi, Moore, Anthony L and Rich, Peter R (2009) Three redox states of Trypanosoma brucei alternative oxidase identified by infrared spectroscopy and electrochemistry. Journal of Biological Chemistry, 284 (46). pp. 31827-31833. ISSN 0021-9258

Moore, Anthony L and Albury, Mary S (2008) Further insights into the structure of the alternative oxidase: from plants to parasites. Biochemical Society Transactions, 36. pp. 1022-1026. ISSN 0300-5127

Wagner, Anneke M, Krab, Klaas, Wagner, Marijke J and Moore, Anthony L (2008) Regulation of thermogenesis in flowering Araceae: The role of the alternative oxidase. BBA - Bioenergetics, 1777 (7-8). pp. 993-1000. ISSN 0005-2728

Moore, Anthony L, Carré, Jane E, Affourtit, Charles, Albury, Mary S, Crichton, Paul G, Kita, Kiyoshi and Heathcote, Peter (2008) Compelling EPR evidence that the alternative oxidase is a diiron carboxylate protein. BBA - Biochimica et Biophysica Acta, 1777. pp. 327-330. ISSN 0006-3002

Crichton, Paul G, Affourtit, Charles and Moore, Anthony L (2007) Identification of a mitochondrial alcohol dehydrogenase in Schizosaccharomyces pombe: new insights into energy metabolism. Biochemical Journal, 401 (2). pp. 459-464. ISSN 0264-6021

Parker, R, Harpham, N V J, Flowers, T J, Wood, C K and Moore, A L (2005) Proteomic characterisation of the response to salt stress in Oryza sativa leaf tissue. Comparative Biochemistry and Physiology - Part A: Molecular and Integrative Physiology, 141 (3). S342-S342. ISSN 1095-6433

Crichton, Paul G, Affourtit, Charles, Albury, Mary S, Carre, Jane E and Moore, Anthony L (2005) Constitutive activity of Sauromatum guttatum alternative oxidase in Schizosaccharomyces pombe implicates residues in addition to conserved cysteines in a-keto acid activation. FEBS Letters, 579 (2). pp. 331-336. ISSN 0014-5793

Affourtit, Charles and Moore, Anthony L (2004) Purification of the plant alternative oxidase from Arum maculatum: measurement, stability and metal requirement. BBA - Biochimica et Biophysica Acta, 1608 (2-3). pp. 181-189. ISSN 0006-3002

Moore, Anthony L, Albury, Mary S, Crichton, Paul G and Affourtit, Charles (2002) Function of the alternative oxidase: is it still a scavenger? Trends in Plant Science, 7 (11). pp. 478-481. ISSN 1360-1385

Affourtit, Charles, Albury, Mary S, Crichton, Paul G and Moore, Anthony L (2002) Exploring the molecular nature of alternative oxidase regulation and catalysis. FEBS Letters, 510 (3). pp. 121-126. ISSN 0014-5793

Albury, Mary S, Affourtit, Charles, Crichton, Paul G and Moore, Anthony L (2002) Structure of the plant alternative oxidase: site-directed mutagenesis provides new information on the active site and membrane topology. Journal of Biological Chemistry, 277 (2). pp. 1190-1194. ISSN 0021-9258

Affourtit, Charles, Krab, Klaas, Leach, Graeme R, Whitehouse, David G and Moore, Anthony L (2001) New insights in the regulation of plant succinate dehydrogenase on the role of the protonmotive force. Journal of Biological Chemistry, 276 (35). pp. 32567-32574. ISSN 0021-9258

Affourtit, Charles, Krab, Klaas and Moore, Anthony L (2001) Control of plant mitochondrial respiration. BBA - Bioenergetics, 1504 (1). pp. 58-69. ISSN 0005-2728

Joseph-Horne, Tim, Wood, Paul M, Wood, Carlton K, Moore, Anthony L, Headrick, John and Hollomon, Derek (1998) Characterization of a split respiratory pathway in the wheat ""take-all"" fungus Gaeumannomyces graminis var. i tritici. Journal of Biological Chemistry, 273 (18). pp. 11127-11133. ISSN 0021-9258

Albury, Mary S, Affourtit, Charles and Moore, Anthony L (1998) A highly conserved glutamate residue (E270) is essential for plant alternative oxidase activity. Journal of Biological Chemistry, 273. pp. 30301-30306.

Albury, Mary S, Dudley, Penelope, Watts, Felicity Z and Moore, Anthony L (1996) Targeting the plant alternative oxidase protein to i Schizosaccharomyces pombe mitochondria confers cyanide-insensitive respiration. Journal of Biological Chemistry, 271 (29). pp. 17062-17066. ISSN 0021-9258

Book Section

Wood, C K, Affourtit, C, Albury, M S, Carre, J, Dudley, P, Gordon, J, Harpham, N V J, Whitehouse, D G and Moore, A L (1998) Over-expression of the mitochondrial matrix located HSP70 in transgenic tobacco results in enhanced growth characteristics. In: Møller, I M and et al, (eds.) Plant mitochondria: from gene to function: proceedings of the International Congress on Plant Mitochondria: from Gene to Function, Aronsborg, Sweden, 22-27 June, 1998. Backhuys Publishers, Leiden, pp. 211-217. ISBN 9057820099