Professor Liz Hill

Reports. 

The final report of the Interreg IV funded project is available here: Determination of relevant indicators for environmental monitoring (DIESE).

Journal Publications.

Arrebola JP, Molina-Molina JM, Fernandez MF, Saenz JM, Amaya E, Indiveri P, Hill EM, Scholze M, Orton F, Kortenkamp A, Olea N (2015) A novel biomarker for anti-androgenic activity in placenta reveals risks of urogenital malformations. Reproduction 149 (6):605-613 

Chetwynd, A.J; Abdul-Sada, A.; Hill, E.M. 2015. Solid phase extraction and nanoflow liquid chromatography-nanoelectrospray ionisation mass spectrometry for improved global urine metabolomics. Anal. Chem. 87 (2):1158-1165 .

Alvarez-Muñoz, D; Indiveri, P; Rostkowski, P;Horwood, J; Greer, E; Minier, C; Pope, N; Langston, B; Hill, E.M. 2015. Widespread contamination of coastal sediments in the Transmanche Channel with anti-androgenic compounds. Mar. Poll. Bull. 95 (2): 590-597.

Hartley, S. E.; Eschen, R.; Horwood, J. M.; Gange, A. C.; Hill, E. M., 2015  Infection by a foliar endophyte elicits novel arabidopside-based plant defence reactions in its host, Cirsium arvense. New Phytol. 205, (2), 816-827.

David, A.; Abdul-Sada, A.; Lange, A.; Tyler, C. R.; Hill, E. M., 2014 A new approach for plasma (xeno)metabolomics based on solid-phase extraction and nanoflow liquid chromatography-nanoelectrospray ionisation mass spectrometry. J. Chrom. A. 1365, 72-85.

Chetwynd, A. J.; David, A.; Hill, E. M.; Abdul-Sada, A., 2014.  Evaluation of analytical performance and reliability of direct nanoLC-nanoESI-high resolution mass spectrometry for profiling the (xeno)metabolome. J.Mass Spectrom. 49, (10), 1063-1069.

Indiveri, P.; Horwood, J.; Abdul-Sada, A.; Arrebola, J. P.; Olea, N.; Hill, E. M., 2014 Analytical methodology for the profiling and characterization of androgen receptor active compounds in human placenta. Reprod. Toxicol. 47, 102-110.

 Liscio, C.; Abdul-Sada, A.; Al-Salhi, R.; Ramsey, M. H.; Hill, E. M., 2014. Methodology for profiling anti-androgen mixtures in river water using multiple passive samplers and bioassay-directed analyses. Wat. Res.  57, 258-269.

 Southam, A. D.; Lange, A.; Al-Salhi, R.; Hill, E. M.; Tyler, C. R.; Viant, M. R., 2014. Distinguishing between the metabolome and xenobiotic exposome in environmental field samples analysed by direct-infusion mass spectrometry based metabolomics and lipidomics. Metabolomics  10, (6), 1050-1058.

Alvarez-Munoz, D.; Al-Salhi, R.; Abdul-Sada, A.; Gonzalez-Mazo, E.; Hill, E. M., 2014. Global Metabolite Profiling Reveals Transformation Pathways and Novel Metabolomic Responses in Solea senegalensis after Exposure to a Non-ionic Surfactant. Environ. Sci. & Technol. 48, (9), 5203-5210.

Hartley, S. E.; Eschen, R.; Horwood, J. M.; Robinson, L.; Hill, E. M., Plant secondary metabolites and the interactions between plants and other organisms: the potential of a metabolomic approach. Ecol. Rev. 2012, 204-225.

Al-Salhi, R.; Abdul-Sada, A.; Lange, A.; Tyler, C. R.; Hill, E. M., 2012 The Xenometabolome and Novel Contaminant Markers in Fish Exposed to a Wastewater Treatment Works Effluent.  Environ. Sci. and Technol, 46, (16), 9080-9088.

Cubero-Leon, E.; Minier, C.; Rotchell, J. M.; Hill, E. M., 2012 Metabolomic analysis of sex specific metabolites in gonads of the mussel, Mytilus edulis. Comp. Biochem. and Physiol. D-Genomics & Proteomics, 7, (2), 212-219.

Cubero-Leon, E.; Puinean, A. M.; Labadie, P.; Ciocan, C.; Itoh, N.; Kishida, M.; Osada, M.; Minier, C.; Hill, E. M.; Rotchell, J. M., 2012.Two CYP3A-like genes in the marine mussel Mytilus edulis: mRNA expression modulation following short-term exposure to endocrine disruptors. Mar. Environ. Res. 74, 32-39.

Rostkowski, P.; Horwood, J.; Shears, J. A.; Lange, A.; Oladapo, F. O.; Besselink, H. T.; Tyler, C. R.; Hill, E. M., 2011. Bioassay-Directed Identification of Novel Antiandrogenic Compounds in Bile of Fish Exposed to Wastewater Effluents.  Environ. Sci. and Technol. 45, (24), 10660-10667.   This paper was highlighted in the journal Chemistry and Engineering News as key environmental research on the identification of new and emerging pollutants in the environment.

Southam, A. D.; Lange, A.; Hines, A.; Hill, E. M.; Katsu, Y.; Iguchi, T.; Tyler, C. R.; Viant, M. R., 2011. Metabolomics Reveals Target and Off-Target Toxicities of a Model Organophosphate Pesticide to Roach (Rutilus rutilus): Implications for Biomonitoring. Environ. Sci. and Technol. 45, (8), 3759-3767.

Flores, A.M., Horwood, J. and Hill, E.M. 2010 Disruption of the steroid metabolome in fish caused by exposure to the environmental estrogen, 17α-ethinylestradiol. Environ. Sci. and Technol. 44 3552-3558.

Mehinto, A.C., Hill, E.M., and Tyler, C.R.2010.  Uptake and biological effects of environmentally relevant concentrations of the non steroidal anti-inflammatory pharmaceutical diclofenac in rainbow trout (Oncorhynchus mykiss). Environ. Sci. and Technol. 442176-2182.

Ciocan, C. M.; Cubero-Leon, E.; Puinean, A. M.; Hill, E. M.; Minier, C.; Osada, M.; Fenlon, K.; Rotchell, J. M., Effects of estrogen exposure in mussels, Mytilus edulis, at different stages of gametogenesis. Environ. Pollut. 2010, 158, (9), 2977-2984.

Cubero-Leon, E., Ciocan, C., Hill, E.M., Osada, M., Kishida, M., Itoh, N., Kondo, R., Minier, C., Rotchell, J.M.2010. Estrogens disrupt serotonin receptor and cyclooxygenase mRNA expression in the gonads of mussels (Mytilus edulis). Aquat. Toxicol. 98, (2), 178-187.                                                                                                                                                                                                                                                                                                                                                                                           

Hill, E.M., Evans, K.L., Horwood, J., Rostkowski, P., Oladapo, F.O., Gibson, R., Shears, J.A., Tyler, C.R, 2010. Profiles and some initial identifications of (anti)androgenic compounds in fish exposed to wastewater treatment works effluents. Environ. Sci. Technol. 441137-1143.                                                                                                                                                                                                                                              

Fenlon, K., Johnson, A.C., Tyler, C.R., and Hill, E.M. 2010 Gas-liquid chromatography- tandem mass spectrometry methodology for the quantitation of estrogenic contaminants in bile of fish exposed to WwTWs effluent and from wild populations. J. Chromatogr. A. 1217112-118.

Denier, X., Hill, E.M. Rotchell, J., Minier, C. 2009 Estrogenic activity of cadmium, copper and zinc in the yeast estrogen screen. Toxicol. In Vitro. 23569-573.

Tyler, C. R.; Filby, A. L.; Bickley, L. K.; Cumming, R. I.; Gibson, R.; Labadie, P.; Katsu, Y.; Liney, K. E.; Shears, J. A.; Silva-Castro, V.; Urushitani, H.; Lange, A.; Winter, M. J.; Iguchi, T.; Hill, E. M.,  2009. Environmental Health Impacts of Equine Estrogens Derived from Hormone Replacement Therapy. Environ. Sci. Technol. 43 3897-3904.

Flores, A.M and Hill, E.M.. 2008. Methodology for profiling the steroid metabolome in animal tissues using ultra-performance liquid chromatography-electrospray ionization time- of- flight mass spectrometry. Anal. Chem. 808871-8779.                                                                                                                

Flores, A.M. and Hill, E.M. 2008 Formation of estrogenic brominated ethinylestradiol in drinking water: implications for aquatic toxicity testing. Chemosphere.73 1115-1120.

Denier, X.; Couteau, J.; Baudrimont, M.; Hill, E. M.; Rotchell, J.; Minier, C. 2008. In vitro study of the effects of cadmium on the activation of the estrogen response element using the YES screen, Marine Environmental Research, 66108-110.

Labadie, P., Cundy, A.B., Stone, K., Andrews, M., Valbonesi, S., and Hill, E.M. 2007.  Evidence for the migration of steroidal estrogens through river bed sediments. Environ. Sci. and Technol. 41 4299-4304.

Peck, M.R. Labadie, P., Minier C., and Hill, E.M. 2007. Profiles of endogenous and exogenous estrogens in the freshwater mussel, Dreissena polymorpha. Chemosphere. 691-8.

Labadie, P. and Hill, E.M. 2007. Analysis of estrogens in river sediments by liquid chromatography- electrospray ionisation mass spectrometry: Comparison of tandem mass spectrometry and time-of-flight mass spectrometry. J. Chromatogr. A. vol 1141  pages 174-181.

Labadie, P., Peck, M. R. Minier, C. and Hill, E.M. 2007. Identification of steroid fatty acid conjugates formed in the blue mussel Mytilus edulis as a result of exposure to estrogens. Steroids. 72 41-49.

Puinean, M. Labadie, P. Hill, E. M. Osada, M. Kishida, M. Nakao, R Callard, I. P. Rotchell J. M. 2006. Laboratory exposure to 17β estradiol fails to induce vitellogenin and estrogen receptor gene expression in the marine invertebrate Mytilus edulis.  Aquatic Toxicol. 79376-383.

Smith, M.D. and Hill, E.M. 2006. Profiles of short chain oligomers in roach (Rutilus rutilus) exposed to waterborne polyethoxylated nonylphenols. Sci. of the Total Environ.   356100-111.

Hill, E.M and Smith, M.D. 2006. Synthesis and steroid receptor activity of brominated nonylphenols. Chemosphere.   641761-1768.

Gibson R. Smith, M.D. Spary C.J, Tyler C.R, and Hill, E.M. 2005. Mixtures of estrogenic contaminants in fish exposed to sewage treatment effluents. Environ. Sci. and Technol. 39 (8) 2461-2471.

Gibson, R W., Tyler, C.R. and Hill, E.M. 2005. Analytical methodology for the identification of oestrogenic contaminants in fish bile.  J. Chomatogr A. 1006 33-40.

Tyler, C.R, Spary C.J, Gibson  R, Santos, E.M. Shears, J and Hill, E.M. 2005. Accounting for the differences in oestrogenic responses in rainbow trout (Oncorrhynchus mykiss: Salmonidae) and roach (Rutilus rutilus) exposed to effluents from wastewater treatment works. Environ. Sci. and Technol. 39(8) 2599-2607.

Peck. M., Gibson, R.W., Kortenkamp, A., and Hill, E.M. 2004. Profiles of estrogenic contaminants present in effluents and sediments of two UK rivers. Environ. Toxicol  and Chem. 23, (4) 945-952.

Smith, M.D., and Hill, E.M. 2004. Uptake and metabolism of technical nonylphenol and its brominated analogues in the roach (Rutilus rutilus). Aquatic Toxicol. 69359-369.

Pedersen, R.T, and Hill, E.M. 2002.  Tissue distribution and depuration of 4-tert-octylphenol residues in the cyprinid Scardinius erythrophthalmus.   Environ. Sci. and Technol. 363275-3283.

Ferreira-Leach, a., and Hill, E.M. 2001. Bioconcentration and distribution of 4-tert.-octylphenol residues in tissues of the rainbow trout (Oncorhynchus mykiss). Mar. Env. Res. 51(1) 75-89.

Coffa, G., and Hill, E.M. 2000. Discovery of an 11(R)- and 12(S)- lipoxygenase activity in ovaries of the mussel Mytilus edulis.  Lipids. 35(11) 1195-1204.

Harries, J.E, Runnalls, T., Hill, E.M. Harris, C., Maddix, S., Sumpter, J.P. and Tyler, C.R. 2000. Development and validation of a reproductive performance test for endocrine disrupting chemicals using pair-breeding fathead minnows (Pimephales promelas). Environ. Sci. and Technol. 3414) 3003-3011.

Pedersen, R.T, and Hill, E.M. 2000. Biotransformation of the xeno-oestrogen p-tert-octylphenol in hepatocytes of the rainbow trout (Oncorhynchus mykiss).  Xenobiotica. 30(9) 867-879.

Pedersen, R.T, and Hill, E.M.  2000. Identification of novel metabolites of the xenoestrogen 4-tert-octylphenol in primary rat hepatocytes.  Chemico-Biol. Interact. vol 128 (3) pages 189-209.

Ferreira- Leach, A. and Hill, E.M. 2000. Bioconcentration and metabolism of 4-tert-octylphenol in roach (Rutilus rutilus) fry. Analusis. 28 (9) 789-792.

Minier, C., Caltot, G., and Hill, E.M. 2000. An investigation into the incidence of intersex fish in the Seine-Maritime and Sussex regions. Analusis. vol 28 (9) pages 801-806.

Hill, E.M., Eling, T.E, and Nettesheim, P. 1998. Changes in expression of 15-lipoxygenase and prostaglandin H synthase during differentiation of human tracheobronchial epithelial cells.  Am. J. Resp. Cell. Mol. Biol. 18 662-669.

Hill, E.M., Eling, T.E., and Nettesheim, P. 1998. Differentiation dependency of eicosanoid enzyme expression in human tracheobronchial cells. Toxicol. Lett. 96239-244.

Eling, T.E., Hill, E.M., and Glasgow, W.C. 1997 Role of arachidonic acid and linoleic acid metabolism in epidermal growth factor initiated proliferation of Syrian hamster embryo fibroblasts.  Adv. in Exp. Med. and Biol. 400495-500.

Kitzler, J., Hardman, R., Hill, E.M., Reddy, N., Philpot, R., and Eling, T.E. 1997. Cloning and sequencing of prostaglandin H synthetase from rat tracheal epithelial cells: Structural evidence that a TPA regulated mRNA codes for the rat homologue to murine PHS-1. Adv. in Exp. Med. and Biol. 40065-70.

Hill, E.M., Bader, T., Nettesheim, P., and Eling, T.E. 1996. Retinoid-induced differentiation regulates prostaglandin H synthase and cPLA₂ expression in tracheal epithelium. Am J. Physiol. 14L854-L862.

Glasgow, W.C., Hill, E.M., McGown, S.R., Tomer, K.B., and Eling,. T.E. 1996. Regulation of 13(S)-hydroxyoctadecadienoic acid biosynthesis in Syrian hamster embryo fibroblasts by the epidermal growth factor-receptor tyrosine kinase. Mol. Pharm. 49 1042-1048.

Kitzler, J., Hill, E.M., Hardman, R., Reddy, N., Philpot, R., and Eling, T.E. 1995. Analysis and quantitation of splicing variants of the TPA inducible PGHS-1 mRNA in a rat tracheal epithelial cells. Arch. Biochem. Biophys. 316856-863.

Hill, E.M., Macmillan, D.K., Sala, A., Henson, P., and Murphy, R.C. 1995. Properties of LTA₄ synthase in human neutrophil preparations.  Advances in Prostaglandin, Thromboxane and Leukotriene Research. 23155-157.

Macmillan, D.K., Hill, E.M., Sala, A., Sigal, E., Shuman, T., Henson, P.M., and Murphy, R.C. 1994. Eosinophil 15-lipoxygenase is a leukotriene synthase. J. Biol. Chem. 269 26663-26668.

Hill, E.M., Holland, D.L., and East, J. 1993. Egg hatching activity of trihydroxylated eicosanoids in the barnacle Balanus balanoides.  Biochim. Biophys. Acta, vol 1157  pages 297-303. 

Hill, E.M., Fitzpatrick, F.A., and Murphy, R.C. 1992. Biological activity and metabolism of 20-hydroxyarachidonic acid in the human platelet.  Br. J. Pharmacol. 106 267-274.

Hill, E.M., Maclouf, J., Murphy, R.C., and Henson, P.M. 1992.  Reversible membrane association of neutrophil 5-lipoxygenase is accompanied by retention of activity and a change in substrate specificity.   J. Biol. Chem. 26722048-22053.

Hill, E.M. and Murphy, R.C. 1992.   Quantitation of 20-hydroxy-5,8,9,11,14-eicosatetraenoic acid (20-HETE) produced by polymorphonuclear leukocytes using electron capture ionization gas chromatography-mass spectrometry.  Biol. Mass Spectrom.  21249-253.

Hill, E.M. and Holland, D.L. 1992. Identification and egg hatching activity of monooxygenated fatty acids in the barnacle Balanus balanoides.  Proc. Roy. Soc. Lond. B. 24741-46.

Song, W.C., Holland, D.L., and Hill, E.M. 1990. The production of eicosanoids with egg hatching activity in barnacles.  Proc. Roy. Soc. Lond. B. 2419-12.

Hill, E.M., Holland, D.L., Gibson, K.H., Oldfield, A., and Clayton, E. 1988.  Identification and hatching factor activity of a monohydroxyeicosapentaenoic acid in homogenates of the barnacle Elminius modestus.  Proc. Roy. Soc. Lond. B.  234455-461.

Hill, E.M. and Holland, D.L. 1985. The influence of oil shale on intertidal organisms; isolation and characterization of metalloporphyrins that induce settlement of Balanus balanoides and Elminius modestus.  Proc. Roy. Soc. Lond. B.  225107-120.

Holland, D.L., Huxley, R., Hill, E.M., and Crisp, D.J. 1985.  The effect on intertidal organisms of the Blackstone oil shale exposure at Kimmeridge, Dorset, U.K.  Proc. Dorset. Nat. Hist. and Archael. Soc.  107135-139.

Refereed book chapters.

Hill, E.M. and Murphy, R.C. 1993. Synthesis of 20-hydroxyarachidonic acid by the human neutrophil and platelet metabolism. In Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury (Honn, K.V., Marnett, L.J., Nigam, S., and Walden, T.L., Eds) Kluwer Academic Publishers, Boston, M.A. pp. 265-270.

 

Crisp, D.J., Hill, E.M., and Holland, D.L. 1991.  The hatching process in barnacles.  In:  Crustacean Egg Production. (Ed., A.M. Wenner and A. Kuris) Crustacean Issues, 7: A.A., Balkema, Rotterdam.

Crisp, D.J., Holland, D.L., and Hill, E.M. 1991 Eicosanoid production in barnacles. In: Marine Biology,  Its Accomplishments and Future Prospects.   (ed J. Mauchline and T. Nemoto),  Hokusen-Sha, Tokyo, pp. 183-191.