Prof Giamas lab publications to date
2024
- Samuels, M., Jones, W., Turner, C., & Giamas, G. (2024). Abstract PO1-25-01: LMTK3 promotes macrophage M2 polarisation and suppresses monocyte infiltration in breast cancer by altering the proteomic cargo of exosomes. Cancer Research, 84(9_Supplement). doi:10.1158/1538-7445.sabcs23-po1-25-01
Article. View online. - Cho, N., Kontou, G., Smalley, J. L., Bope, C., Dengler, J., Montrose, K., . . . Moss, S. J. (2024). The brain-specific kinase LMTK3 regulates neuronal excitability by decreasing KCC2-dependent neuronal Cl<sup>−</sup> extrusion. iScience, 27(4), pages. doi:10.1016/j.isci.2024.109512
Article. View on figshare. - Torres-Gonzalez, L., Soni, S., Yang, Y., Smbatyan, G., Lo, J. H., Mittal, P., . . . Lenz, H. -J. (2024). Abstract 6832: Gender specific role of LMTK3 in neuronal-tumor microenvironment crosstalk in CRC. Cancer Research, 84(6_Supplement), 6832. doi:10.1158/1538-7445.am2024-6832
Article. View online. - Samuels, M., & Giamas, G. (2024). MISEV2023: shaping the future of EV research by enhancing rigour, reproducibility and transparency. Cancer Gene Therapy, 1-3. doi:10.1038/s41417-024-00759-7
Article. View on figshare. - Mazarakis, N. K., Robinson, S. D., Sinha, P., Koutsarnakis, C., Komaitis, S., Stranjalis, G., . . . Giamas, G. (2024). Management of glioblastoma in elderly patients: a review of the literature. Clinical and Translational Radiation Oncology, 46, pages. doi:10.1016/j.ctro.2024.100761
Article. View on figshare. - Vella, V., Ditsiou, A., Chalari, A., Eravci, M., Wooller, S. K., Gagliano, T., . . . al., E. (n.d.). Kinome-wide synthetic lethal screen identifies PANK4 as a modulator of temozolomide resistance in glioblastoma. Advanced Science, pages. doi:10.1002/advs.202306027
Article. View on figshare. - Malavasi, E., Adamo, M., Zamprogno, E., Vella, V., Giamas, G., & Gagliano, T. (2024). Decoding the Tumour Microenvironment: Molecular Players, Pathways, and Therapeutic Targets in Cancer Treatment. Cancers, 16(3). doi:10.3390/cancers16030626
Article. View online. - Welsh, J. A., Goberdhan, D. C. I., O’Driscoll, L., Buzas, E. I., Blenkiron, C., Bussolati, B., . . . Anderson, J. D. (2024). Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. Journal of Extracellular Vesicles, 13(2). doi:10.1002/jev2.12404
Article. View online. - Torres-Gonzalez, L., Battaglin, F., Soni, S., Baca, Y., Xiu, J., Walker, P., . . . Lenz, H. -J. (2024). <i>LMTK3</i> gene expression and the molecular landscape of colorectal cancer (CRC).. Journal of Clinical Oncology, 42(3_suppl), 172. doi:10.1200/jco.2024.42.3_suppl.172
Article. View online. - Mórotz, G. M., Bradbury, N. A., Caluseriu, O., Hisanaga, S. -I., Miller, C. C. J., Swiatecka-Urban, A., . . . Giamas, G. (2024). A revised nomenclature for the lemur family of protein kinases. Communications Biology, 7, pages. doi:10.1038/s42003-023-05671-8
Article. View on figshare. - Robinson, S. D., De Boisanger, J., Pearl, F. M. G., Critchley, G., Rosenfelder, N., & Giamas, G. (2024). A brain metastasis liquid biopsy: Where are we now?. Neuro-Oncology Advances, 6(1). doi:10.1093/noajnl/vdae066
Article. View online.
2023
- Robinson, S. D., Samuels, M., Jones, W., Gilbert, D., Critchley, G., & Giamas, G. (2023). Shooting the messenger: a systematic review investigating extracellular vesicle isolation and characterisation methods and their influence on understanding extracellular vesicles-radiotherapy interactions in glioblastoma. BMC Cancer, 23(1). doi:10.1186/s12885-023-11437-6
Article. View online. - Du, Z., Zhang, T., Lin, Y., Dong, G., Li, A., Wang, Z., . . . Peng, L. (2023). A prognostic model of drug tolerant persister-related genes in lung adenocarcinoma based on single cell and bulk RNA sequencing data. Heliyon, 9(11). doi:10.1016/j.heliyon.2023.e20708
Article. View online. - Samuels, M., Jones, W., Towler, B., Turner, C., Robinson, S., & Giamas, G. (2023). The role of non-coding RNAs in extracellular vesicles in breast cancer and their diagnostic implications. Oncogene, 42(41), 3017-3034. doi:10.1038/s41388-023-02827-y
Article. View online. - Malavasi, E., Giamas, G., & Gagliano, T. (2023). Estrogen receptor status heterogeneity in breast cancer tumor: role in response to endocrine treatment. Cancer Gene Therapy, 30(7), 932-935. doi:10.1038/s41417-023-00618-x
Article. View online. - Vella, V., Ditsiou, A., Chalari, A., Eravci, M., Wooler, S. K., Gagliano, T., . . . Zhang, Y. (2023). Kinome-wide synthetic lethal screen identifies PANK4 as modulator of resistance in glioblastoma . doi:10.21203/rs.3.rs-2731966/v1
Preprint. View online. - Falcinelli, M., Al-Hity, G., Baron, S., Mampay, M., Allen, M. C., Samuels, M., . . . Flint, M. S. (2023). Propranolol reduces IFN-? driven PD-L1 immunosuppression and improves anti-tumour immunity in ovarian cancer. Brain, Behavior, and Immunity, 110, 1-12. doi:10.1016/j.bbi.2023.02.011
Article. View on figshare. - Agnarelli, A., Betran, A. L., Papakyriakou, A., Vella, V., Samuels, M., Papanastasopoulos, P., . . . Giamas, G. (2023). The inhibitory properties of a novel, selective LMTK3 kinase inhibitor. International Journal of Molecular Sciences, 24(1), e865 1-15. doi:10.3390/ijms24010865
Article. View on figshare. - Samuels, M., Jones, W., Towler, B., Turner, C., Robinson, S., & Giamas, G. (2023). The role of non-coding RNAs in extracellular vesicles in breast cancer and their diagnostic implications. ONCOGENE. doi:10.1038/s41388-023-02827
Article. View online.
2022
- Liang, F., Peng, L., Wu, Z., Giamas, G., & Stebbing, J. (2022). Design and reporting of phase III oncology trials with prospective biomarker validation. Journal of the National Cancer Institute, djac210 1-7. doi:10.1093/jnci/djac210
Article. View on figshare. - Giamas, G., Cilibrasi, C., Simon, T., Stewart, N., Critchley, G., & Eravci, M. (2022). BIOM-06. Identification of an inflammatory biomarker signature in plasma-derived extracellular vesicles of glioblastoma patients. Neuro-Oncology, 24(7), vii5. doi:10.1093/neuonc/noac209.016
Article. View on figshare. - Cilibrasi, C., Simon, T., Vintu, M., Tolias, C., Samuels, M., Mazarakis, N., . . . Giamas, G. (2022). Identification of an Inflammatory Biomarker Signature in Plasma-Derived Extracellular Vesicles of Glioblastoma Patients. Neuro-Oncology, 24(Supplement_4), iv6-iv7. doi:10.1093/neuonc/noac200.027
Article. View online. - Agnarelli, A., Vella, V., Samuels, M., Papanastasopoulos, P., & Giamas, G. (2022). Incorporating immunotherapy in the management of gastric cancer: molecular and clinical implications. Cancers, 14(18), e4378 1-25. doi:10.3390/cancers14184378
Article. View on figshare. - Thaker, P., Flint, M., Giamas, G., Falcinelli, M., Alhity, G., Mampay, M., . . . Samuels, M. (2022). Pharmacologic inhibition of beta-adrenergic receptors decreases PD-L1 mediated immunosuppression and improves anti-tumor immune signature in ovarian cancer (126). Gynecologic Oncology, 166, S80. doi:10.1016/s0090-8258(22)01352-x
Article. View on figshare. - Lane, R., Cilibrasi, C., Chen, J., Shah, K., Messuti, E., Mazarakis, N. K., . . . Giamas, G. (n.d.). PDGF-R inhibition induces glioblastoma cell differentiation via DUSP1/p38MAPK signalling. Oncogene, 1-15. doi:10.1038/s41388-022-02294-x
Article. View on figshare. - Wang, Z., Zhu, L., Li, K., Sun, Y., Giamas, G., Stebbing, J., . . . Yu, Z. (n.d.). Alternative splicing events in tumor immune infiltration in renal clear cell carcinomas. Cancer Gene Therapy, pages. doi:10.1038/s41417-022-00426-9
Article. View on figshare. - Giamas, G., & Spencer, J. (2022). WO/2022/053838, Small molecule inhibitors of Lemur tyrosine kinase 3 (LTK).
Patent. View on figshare. - Giamas, G., & Spencer, J. (2022). WO/2022/053838, Small molecule inhibitors of Lemur tyrosine kinase 3 (LTK).
Patent. View on figshare. - Samuels, M., Cilibrasi, C., Papanastasopoulos, P., & Giamas, G. (2022). Extracellular vesicles as mediators of therapy resistance in breast cancer microenvironment. Biomolecules, 12(1), 1-40. doi:10.3390/biom12010132
Article. View on figshare. - Cilibrasi, C., Simon, T., Vintu, M., Tolias, C., Samuels, M., Mazarakis, N. K., . . . Giamas, G. (2022). Definition of an inflammatory biomarker signature in plasma-derived extracellular vesicles of glioblastoma patients. Biomedicines, 10(1), 1-15. doi:10.3390/biomedicines10010125
Article. View on figshare.
2021
- Zhu, L., Wang, Z., Sun, Y., Giamas, G., Stebbing, J., Yu, Z., & Peng, L. (2021). A prediction model using alternative splicing events and the immune microenvironment signature in lung adenocarcinoma. Frontiers in Oncology, 11, 1-14. doi:10.3389/fonc.2021.778637
Article. View on figshare. - Brown, C., Simon, T., Cilibrasi, C., Lynch, P., Harries, R., Graf, A. A., . . . King, A. (2022). Tuneable synthetic reduced graphene oxide scaffolds elicit high levels of three-dimensional glioblastoma interconnectivity in vitro. Journal of Materials Chemistry B, 10(30), 373-383. doi:10.1039/d1tb01266e
Article. View on figshare. - Vella, V., Giamas, G., & Ditsiou, A. (n.d.). Diving into the dark kinome: lessons learned from LMTK3. Cancer Gene Therapy, pages. doi:10.1038/s41417-021-00408-3
Article. View on figshare. - Cilibrasi, C., Papanastasopoulos, P., Samuels, M., & Giamas, G. (2021). Reconstituting immune surveillance in breast cancer: molecular pathophysiology and current immunotherapy strategies. International Journal of Molecular Sciences, 22(21), 1-20. doi:10.3390/ijms222112015
Article. View on figshare. - Peng, L., Li, J., Wu, J., Xu, B., Wang, Z., Giamas, G., . . . Yu, Z. (2021). A pan-cancer analysis of SMARCA4 alterations in human cancers. Frontiers in Immunology, 12, 1-15. doi:10.3389/fimmu.2021.762598
Article. View on figshare. - Burn, L., Gutowski, N., Whatmore, J., Giamas, G., & Pranjol, M. Z. I. (2021). The role of astrocytes in brain metastasis at the interface of circulating tumour cells and the blood brain barrier. Frontiers in Bioscience-Landmark, 26(9), 590-601. doi:10.52586/4969
Article. View on figshare. - Ditsiou, A., Gagliano, T., Samuels, M., Vella, V., Tolias, C., & Giamas, G. (2021). The multifaceted role of lemur tyrosine kinase 3 in health and disease. Open biology, 11(9), 1-12. doi:10.1098/rsob.210218
Article. View on figshare. - Chrysostomou, S., Roy, R., Prischi, F., Thamlikitkul, L., Chapman, K. L., Mufti, U., . . . others. (2021). Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer. Science Translational Medicine, 13(602), pages. doi:10.1126/scitranslmed.aba4627
Article. View on figshare. - Lepore, A., Choy, P. M., Lee, N. C. W., Carella, M. A., Favicchio, R., Briones-Orta, M. A., . . . Papa, S. (2021). Phosphorylation and stabilization of PIN1 by JNK promote intrahepatic cholangiocarcinoma growth. Hepatology, 74(5), 2561-2579. doi:10.1002/hep.31983
Article. View on figshare. - Giamas, G., & Gagliano, T. (2022). Cancer gene therapy 2020: highlights from a challenging year. Cancer Gene Therapy, 29(1), 1-3. doi:10.1038/s41417-021-00340-6
Article. View on figshare. - Stebbing, J., Zhang, H., Xu, Y., Lit, L. C., Green, A. R., Grothey, A., . . . Giamas, G. (n.d.). Correction: KSR1 regulates BRCA1 degradation and inhibits breast cancer growth. Oncogene. doi:10.1038/s41388-021-01794-6
Article. View online. - Cilibrasi, C., Ditsiou, A., Papakyriakou, A., Mavridis, G., Eravci, M., Stebbing, J., . . . Giamas, G. (2021). Correction to: LMTK3 inhibition affects microtubule stability. Molecular Cancer, 20(1), 1-3. doi:10.1186/s12943-021-01353-3
Article. View on figshare. - Cilibrasi, C., Ditsiou, A., Papakyriakou, A., Mavridis, G., Eravci, M., Stebbing, J., . . . Giamas, G. (2021). LMTK3 inhibition affects microtubule stability. Molecular Cancer, 20, 1-6. doi:10.1186/s12943-021-01345-3
Article. View on figshare. - Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., . . . others. (n.d.). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy, 1-382. doi:10.1080/15548627.2020.1797280
Article. View on figshare.
2020
- Ditsiou, A., Cilibrasi, C., Simigdala, N., Harris, L., Vella, V., Gagliano, T., . . . others. (2020). The structure-function relationship of oncogenic LMTK3. Science Advances, 6(46), 1-19. doi:10.1126/sciadv.abc3099
Article. View on figshare. - Shah, K., Gagliano, T., Garland, L., O’Hanlon, T., Bortolotti, D., Gentili, V., . . . Dean, M. (n.d.). Androgen receptor signaling regulates the transcriptome of prostate cancer cells by modulating global alternative splicing. Oncogene, pages. doi:10.1038/s41388-020-01429-2
Article. View on figshare. - Harries, R., Brown, C., Ogilvie, S., Large, M., Graf, A. A., Clifford, K., . . . King, A. (n.d.). Langmuir films of layered nanomaterials: edge interactions and cell culture applications. Journal of Physical Chemistry B, pages. doi:10.1021/acs.jpcb.0c05573
Article. View on figshare. - Simon, T., Jackson, E., & Giamas, G. (n.d.). Breaking through the glioblastoma micro-environment via extracellular vesicles. Oncogene, 1-14. doi:10.1038/s41388-020-1308-2
Article. View on figshare. - Simon, T., Kumaran, A., Veselu, D. -F., & Giamas, G. (n.d.). Three method-combination protocol for improving purity of extracellular vesicles. International Journal of Molecular Sciences, 21(9), pages. doi:10.3390/ijms21093071
Article. View on figshare. - Martelli, C., King, A., Simon, T., & Giamas, G. (n.d.). Graphene-induced transdifferentiation of cancer stem cells as a therapeutic strategy against glioblastoma. ACS Biomaterials Science & Engineering, pages. doi:10.1021/acsbiomaterials.0c00197
Article. View on figshare. - Gagliano, T., Shah, K., Gargani, S., Lao, L., Alsaleem, M., Chen, J., . . . others. (2020). PIK3Cd expression by fibroblasts promotes triple-negative breast cancer progression. Journal of Clinical Investigation, 130(6), 3188-3204. doi:10.1172/JCI128313
Article. View on figshare. - Giamas, G. (2020). Reviewer recognition. Cancer gene therapy, 27, pages. doi:10.1038/s41417-020-0168-9
Article. View on figshare. - Giamas, G. (2020). [Editorial] Cancer gene therapy: vision and strategy for the new decade. Cancer Gene Therapy, 27, 115 ( pages). doi:10.1038/s41417-020-0169-8
Article. View on figshare.
2019
- Shah, K., Gagliano, T., Garland, L., O’Hanlon, T., Bortolotti, D., Gentili, V., . . . Dean, M. (2019). Androgen Receptor Signaling Regulates the Transcriptome of Prostate Cancer Cells by Modulating Global Alternative Splicing. doi:10.1101/828707
Preprint. View online. - Gagliano, T., Shah, K., Gargani, S., Lao, L., Alsaleem, M., Chen, J., . . . Giamas, G. (2019). Global kinome silencing combined with 3D invasion screening of the tumor microenvironment identifies fibroblast-expressed PIK3Cδ involvement in triple-negative breast cancer progression. doi:10.1101/822049
Preprint. View online. - Bresciani, G., Hofland, L. J., Dogan, F., Giamas, G., Gagliano, T., & Zatelli, M. C. (2019). Evaluation of spheroid 3D culture methods to study a pancreatic neuroendocrine neoplasm cell line. Frontiers in Endocrinology, 10, 1-10. doi:10.3389/fendo.2019.00682
Article. View on figshare. - Chrysostomou, S., Roy, R., Prischi, F., Chapman, K., Mufti, U., Mauri, F., . . . Pardo, O. (2019). Abstract 1775: Targeting RSK4 prevents both chemoresistance and metastasis in lung cancer. In Cancer Research Vol. 79 (pp. 1775). American Association for Cancer Research (AACR). doi:10.1158/1538-7445.am2019-1775
Conference publication. View online. - Chrysostomou, S., Roy, R., Prischi, F., Chapman, K., Mufti, U., Mauri, F., . . . Pardo, O. (2019). Abstract 1775: Targeting RSK4 prevents both chemoresistance and metastasis in lung cancer. In Molecular and Cellular Biology / Genetics. American Association for Cancer Research. doi:10.1158/1538-7445.sabcs18-1775
Conference publication. View online. - Rani, A., Stebbing, J., Giamas, G., & Murphy, J. (n.d.). Endocrine resistance in hormone receptor positive breast cancer–from mechanism to therapy. Frontiers in Endocrinology, 10(245), 1-32. doi:10.3389/fendo.2019.00245
Article. View on figshare. - Bresciani, G., Ditsiou, A., Cilibrasi, C., Vella, V., Rea, F., Schiavon, M., . . . Gagliano, T. (n.d.). EGF and IGF1 affect Sunitinib activity in BP-NEN: new putative targets beyond VEGFR?. Endocrine Connections, 8(6), 680-690. doi:10.1530/EC-19-0192
Article. View on figshare. - Bresciani, G., Ditsiou, A., Cilibrasi, C., Vella, V., Rea, F., Schiavon, M., . . . Gagliano, T. (2019). EGFR and IGF1R affect Sunitinib activity: novel targets for Broncho-Pulmonary Neuroendocrine Neoplasm treatment. Endocrine Abstracts, pages. doi:10.1530/endoabs.63.p464
Article. View on figshare. - Bresciani, G., Hofland, L. J., Giamas, G., Gagliano, T., & Zatelli, M. C. (2019). Available 3D cultures methods: study on a Pancreatic Neuroendocrine Neoplasm cell line. Endocrine Abstracts, pages. doi:10.1530/endoabs.63.p40
Article. View on figshare. - Bresciani, G., Ditsiou, A., Cilibrasi, C., Vella, V., Giamas, G., Zatelli, M. C., & Gagliano, T. (2019). Influence of Tumor Microenviroment in response modulation to treatment in human BP-NENs. Endocrine Abstracts, pages. doi:10.1530/endoabs.63.p38
Article. View on figshare.
2018
- Wendler, F., Purice, T. -M., Simon, T., Stebbing, J., & Giamas, G. (2021). The LMTK-family of kinases: emerging important players in cell physiology and pathogenesis. BBA - Molecular Basis of Disease, 1867(9), 1-7. doi:10.1016/j.bbadis.2018.12.023
Article. View on figshare. - Brandao, M., Simon, T., Critchley, G., & Giamas, G. (2019). Astrocytes, the rising stars of the glioblastoma microenvironment. Glia, 67(5), 779-790. doi:10.1002/glia.23520
Article. View on figshare. - Simon, T., Pinioti, S., Schellenberger, P., Rajeeve, V., Wendler, F., Cutillas, P. R., . . . Giamas, G. (n.d.). [Letter to editor] Shedding of bevacizumab in tumour cells derived extracellular vesicles as a new therapeutic escape mechanism in glioblastoma. Molecular Cancer, 17(132), 1-7. doi:10.1186/s12943-018-0878-x
Article. View on figshare. - Gagliano, T., Vella, V., Bienkowska, K., Ditsiou, A., & Giamas, G. (2018). Abstract 2087: Fibroblast-kinome siRNA screening identifies PIK3Cδ as a mediator of Triple-negative breast cancer (TNBC) invasion. In Cancer Research Vol. 78 (pp. 2087). American Association for Cancer Research (AACR). doi:10.1158/1538-7445.am2018-2087
Conference publication. View online. - Gagliano, T., Vella, V., Bienkowska, K., Ditsiou, A., & Giamas, G. (2018). Fibroblast-kinome silencing to identifies putative mediator of Triple-negative breast cancer (TNBC) invasion. Endocrine Abstracts, pages. doi:10.1530/endoabs.56.p654
Article. View on figshare. - Ditsiou, A., Gagliano, T., Prodromou, C., Gascon, J., Mumford, S., Grand, D. L., & Giamas, G. (2018). Targeting treatment resistance in breast cancer subtypes via LMTK3 inhibition. In Endocrine Abstracts (pp. 651 ( pages)). Barcelona, Spain: Bioscientifica. doi:10.1530/endoabs.56.p651
Conference publication. View on figshare. - Stebbing, J., Shah, K., Lit, L. C., Gagliano, T., Ditsiou, A., Wang, T., . . . Giamas, G. (2018). LMTK3 confers chemo-resistance in breast cancer. Oncogene, 37(23), 3113-3130. doi:10.1038/s41388-018-0197-0
Article. View on figshare. - Giamas, G., Vella, V., Ditsiou, A., & Teresa, T. (2018). Abstract P5-03-04: Not presented. In Cancer Research Vol. 78. American Association for Cancer Research (AACR). doi:10.1158/1538-7445.sabcs17-p5-03-04
Conference publication. View online.
2017
- Gagliano, T., Ditsiou, A., Grothey, A., & Giamas, G. (2017). ER status heterogeneity in breast cancer: role in response to endocrine treatment. Endocrine Abstracts, pages. doi:10.1530/endoabs.49.ep785
Article. View on figshare. - Giamas, G., Grothey, T., Grothey, A., & Stebbing, J. (2017). Abstract P4-03-02: Stromal kinome screening identifies a novel regulatory kinase implicated in fibroblast-mediated progression of invasion in triple negative breast cancer tumours. In Cancer Research Vol. 77. American Association for Cancer Research (AACR). doi:10.1158/1538-7445.sabcs16-p4-03-02
Conference publication. View online. - Simon, T., Gagliano, T., & Giamas, G. (2017). Direct effects of anti-angiogenic therapies on tumor cells: VEGF signaling. Trends in Molecular Medicine, 23(3), 282-292. doi:10.1016/j.molmed.2017.01.002
Article. View on figshare.
2016
- Gagliano, T., Simon, T., & Giamas, G. (2016). miRNA transported by exosomes: a key machinery in tumor microenvironment mediated chemoresistance. Translational Cancer Research, 5(S7), S1479-S1482. doi:10.21037/tcr.2016.12.40
Article. View on figshare. - Wendler, F., Favicchio, R., Simon, T., Alifrangis, C., Stebbing, J., & Giamas, G. (2017). Extracellular vesicles swarm the cancer microenvironment: from tumor–stroma communication to drug intervention. Oncogene, 36(7), 877-884. doi:10.1038/onc.2016.253
Article. View on figshare. - Favicchio, R., Angelopoulos, N., Brickute, D., Fortt, R., Twyman, F., Giamas, G., . . . Aboagye, E. O. (2016). Abstract 4235: Choline metabolism is an early predictor of EGFR-mediated survival in NSCLC. In Cancer Research Vol. 76 (pp. 4235). American Association for Cancer Research (AACR). doi:10.1158/1538-7445.am2016-4235
Conference publication. View online. - Lucchiari, G., Zhang, H., Nunes, J., Xu, Y., Grothey, A., Stebbing, J., & Giamas, G. (2016). Abstract 185: Role of phosphorylation in Lmtk3 activation and its contribution in breast cancer progression. In Cancer Research Vol. 76 (pp. 185). American Association for Cancer Research (AACR). doi:10.1158/1538-7445.am2016-185
Conference publication. View online. - Angelopoulos, N., Abdallah, S., & Giamas, G. (2016). Advances in integrative statistics for logic programming. International Journal of Approximate Reasoning, 78, 103-115. doi:10.1016/j.ijar.2016.06.008
Article. View on figshare. - Wendler, F., Stamp, G., & Giamas, G. (2016). Tumor–stromal cell communication: small vesicles signal big changes. Trends in Cancer, 2(7), 326-329. doi:10.1016/j.trecan.2016.05.007
Article. View on figshare. - Nunes, J., Zhang, H., Angelopoulos, N., Chhetri, J., Osipo, C., Grothey, A., . . . Giamas, G. (2016). ATG9A loss confers resistance to trastuzumab via c-Cbl mediated Her2 degradation. Oncotarget, 7(19), 27599-27612. doi:10.18632/oncotarget.8504
Article. View on figshare. - Angelopoulos, N., Stebbing, J., Xu, Y., Giamas, G., & Zhang, H. (2016). Proteome-wide dataset supporting functional study of tyrosine kinases in breast cancer. Data in Brief, 7, 740-746. doi:10.1016/j.dib.2016.03.024
Article. View on figshare. - Jacob, J., Favicchio, R., Karimian, N., Mehrabi, M., Harding, V., Castellano, L., . . . Giamas, G. (2016). LMTK3 escapes tumour suppressor miRNAs via sequestration of DDX5. Cancer Letters, 372(1), 137-146. doi:10.1016/j.canlet.2015.12.026
Article. View on figshare. - Favicchio, R., Thepaut, C., Zhang, H., Arends, R., Stebbing, J., & Giamas, G. (2016). Strategies in functional proteomics: unveiling the pathways to precision oncology. Cancer Letters, 382(1), 86-94. doi:10.1016/j.canlet.2016.01.049
Article. View on figshare.
2015
- Rampias, T., Favicchio, R., Stebbing, J., & Giamas, G. (2016). Targeting tumor-stroma crosstalk: the example of the NT157 inhibitor. Oncogene, 35(20), 2562-2564. doi:10.1038/onc.2015.392
Article. View on figshare. - Schofield, G. M., Urch, C. E., Stebbing, J., & Giamas, G. (2016). Reply: when does a human being die?. QJM, 109(2), 146 ( pages). doi:10.1093/qjmed/hcv164
Article. View on figshare. - Xu, Y., Zhang, H., Nguyen, V., Angelopoulos, N., Nunes, J., Reid, A., . . . Giamas, G. (2015). LMTK3 represses tumor suppressor-like genes through chromatin remodeling in breast cancer. Cell Reports, 12(5), 837-849. doi:10.1016/j.celrep.2015.06.073
Article. View on figshare. - Angelopoulos, N., Abdallah, S., & Giamas, G. (2015). Advances in integrating statistical inference. In CEUR Workshop Proceedings Vol. 1413 (pp. 9-18). Cork, Ireland: CEUR Workshop Proceedings.
Conference publication. View on figshare. - Stebbing, J., Zhang, H., Xu, Y., Grothey, A., Ajuh, P., Angelopoulos, N., & Giamas, G. (2015). Reprogramming of the tyrosine kinase-regulated proteome in breast cancer by combined use of RNAi and SILAC quantitative proteomics. Molecular and Cellular Proteomics : MCP, 14, 2479-2492. doi:10.1074/mcp.M115.048090
Article. View on figshare. - Zhang, H., Angelopoulos, N., Xu, Y., Grothey, A., Nunes, J., Stebbing, J., & Giamas, G. (2015). Proteomic profile of KSR1-regulated signalling in response to genotoxic agents in breast cancer. Breast Cancer Research and Treatment, 151(3), 555-568. doi:10.1007/s10549-015-3443-y
Article. View on figshare. - Stebbing, J., Zhang, H., Xu, Y., Lit, L. C., Green, A. R., Grothey, A., . . . Giamas, G. (2015). KSR1 regulates BRCA1 degradation and inhibits breast cancer growth. Oncogene, 34(16), 2103-2114. doi:10.1038/onc.2014.129
Article. View on figshare. - Papanastasopoulos, P., & Giamas, G. (2015). mTOR inhibition in breast cancer. Breast Cancer Management, 4(2), 67-70. doi:10.2217/BMT.14.54
Article. View on figshare. - Benhaim, L., Zhang, W., Wakatsuki, T., Yang, D., Gerger, A., Bohanes, P., . . . Lenz, H. J. (2015). Genetic variants of kinase suppressors of Ras (KSR1) to predict survival in patients with ERa-positive advanced breast cancer. The Pharmacogenomics Journal, 15(3), 235-240. doi:10.1038/tpj.2014.58
Article. View on figshare. - Zhang, H., Stebbing, J., & Giamas, G. (2015). The many-faced KSR1: a tumor suppressor in breast cancer. Oncoscience, 2(8), 669-670. doi:10.18632/oncoscience.219
Article. View on figshare. - Angelopoulos, N., & Giamas, G. (2015). A logical approach to working with biological databases. In CEUR Workshop Proceedings Vol. 1433.
Conference publication.
2014
- Zhang, H., Xu, Y., Papanastasopoulos, P., Stebbing, J., & Giamas, G. (2014). Broader implications of SILAC-based proteomics for dissecting signaling dynamics in cancer. Expert Review of Proteomics, 11(6), 713-731. doi:10.1586/14789450.2014.971115
Article. View on figshare. - Schofield, G. M., Urch, C. E., Stebbing, J., & Giamas, G. (2015). When does a human being die?. QJM: An International Journal of Medicine, 108(8), 605-609. doi:10.1093/qjmed/hcu239
Article. View on figshare. - Nunes, J. F. G., Zhang, H., Stebbing, J., Angelopoulos, N., & Giamas, G. (2014). Silac-based analysis reveals a unique phosphoproteomic-signature of her2-resistant breast cancer cells. In Anticancer Research Vol. 34 (pp. 5900). Sithonia, Greece: International Institute of Anticancer Research.
Conference publication. View on figshare. - Xu, Y., Zhang, H., Vorgias, C., Stebbing, J., & Giamas, G. (2014). Positioning LMTK3 on the map of oncogenic signaling cascades and elucidating its role in invasion and metastasis in breast cancer. In Anticancer Research Vol. 34 (pp. 5923-5924). Sithonia, Greece: International Institute of Anticancer Research.
Conference publication. View on figshare. - Xu, Y., Zhang, H., & Giamas, G. (2014). Targeting lemurs against cancer metastasis. Oncotarget, 5(14), 5192-5193. doi:10.18632/oncotarget.2271
Article. View on figshare. - Xu, Y., Zhang, H., Lit, L. C., Grothey, A., Athanasiadou, M., Kiritsi, M., . . . Giamas, G. (2014). The kinase LMTK3 promotes invasion in breast cancer through GRB2-mediated induction of integrin ß1. Science signaling, 7(330), ra58 ( pages). doi:10.1126/scisignal.2005170
Article. View on figshare. - Stebbing, J., Lit, L. C., Zhang, H., Darrington, R. S., Melaiu, O., Rudraraju, B., & Giamas, G. (2014). The regulatory roles of phosphatases in cancer. Oncogene, 33(8), 939-953. doi:10.1038/onc.2013.80
Article. View on figshare. - Winder, T., Giamas, G., Wilson, P. M., Zhang, W., Yang, D., Bohanes, P., . . . Lenz, H. -J. (2014). Insulin-like growth factor receptor polymorphism defines clinical outcome in estrogen receptor-positive breast cancer patients treated with tamoxifen. The Pharmacogenomics Journal, 14(1), 28-34. doi:10.1038/tpj.2013.8
Article. View on figshare. - Melaiu, O., Stebbing, J., Lombardo, Y., Bracci, E., Uehara, N., Bonotti, A., . . . Landi, S. (2014). MSLN gene silencing has an anti-malignant effect on cell lines overexpressing mesothelin deriving from malignant pleural mesothelioma. PLoS ONE, 9(1), pages. doi:10.1371/journal.pone.0085935
Article. View on figshare. - Magturo, S., Giamas, G., Mallick, S., Layton, A., Stebbing, J., Lenz, H. -J., & LaBonte, M. J. (2014). Evaluation of LMTK3 expression and tumor phenotype in estrogen-dependent colorectal cancer. In CANCER RESEARCH Vol. 74. doi:10.1158/1538-7445.AM2014-4213
Conference publication. View online. - Zhang, H., Stebbing, J., Xu, Y., & Giamas, G. (2014). Global mapping of tyrosine kinase signalling in breast cancer by combined use of RNAi and SILAC quantitative proteomics. In CANCER RESEARCH Vol. 74. doi:10.1158/1538-7445.AM2014-1606
Conference publication. View online.
2013
- Fentiman, I., Cartlidge, C., Dixon, J. M., Giamas, G., & Kiritsi, M. (2013). Journal Watch: Our panel of experts highlight the most important research articles across the spectrum of topics relevant to the field of breast cancer management. Breast Cancer Management, 2(6), 455-457. doi:10.2217/bmt.13.60
Article. View on figshare. - Stebbing, J., Filipovic, A., & Giamas, G. (2013). Claudin-1 as a promoter of EMT in hepatocellular carcinoma. Oncogene, 32(41), 4871-4872. doi:10.1038/onc.2012.591
Article. View on figshare. - Wakatsuki, T., LaBonte, M. J., Bohanes, P. O., Zhang, W., Yang, D., Azuma, M., . . . Lenz, H. -J. (2013). Prognostic role of lemur tyrosine kinase-3 germline polymorphisms in adjuvant gastric cancer in Japan and the United States. Molecular Cancer Therapeutics, 12(10), 2261-2272. doi:10.1158/1535-7163.MCT-12-1134
Article. View on figshare. - Zhang, H., Koo, C. Y., Stebbing, J., & Giamas, G. (2013). The dual function of KSR1: a pseudokinase and beyond. Biochemical Society Transactions, 41(4), 1078-82. doi:10.1042/BST20130042
Article. View on figshare. - Stebbing, J., Filipovic, A., Lit, L. C., Blighe, K., Grothey, A., Xu, Y., . . . Giamas, G. (2013). LMTK3 is implicated in endocrine resistance via multiple signaling pathways. Oncogene, 32(28), 3371-3380. doi:10.1038/onc.2012.343
Article. View on figshare. - Filipovic, A., Stebbing, J., & Giamas, G. (2013). Cancer stem cells - therapeutic targeting or therapy?. Lancet Oncology, 14(7), 579-580. doi:10.1016/S1470-2045(13)70258-4
Article. View on figshare. - Zhang, H., Stebbing, J., Filipovic, A., Ellis, I. O., Lenz, H. -J., & Giamas, G. (2013). Abstract 4316: A dynamic interplay of KSR1, p53 and BRCA1 in breast cancer.. In Cancer Research Vol. 73 (pp. 4316). American Association for Cancer Research (AACR). doi:10.1158/1538-7445.am2013-4316
Conference publication. View online. - Xu, Y., Filipovic, A., Zhang, H., Lit, L. C., Lombardo, Y., Stebbing, J., & Giamas, G. (2013). The role of LMTK3 in breast cancer cell growth and invasion. In CANCER RESEARCH Vol. 73. doi:10.1158/1538-7445.AM2013-3794
Conference publication. View online. - Zhang, H., Xu, Y., Filipovic, A., Lit, L. C., Koo, C. -Y., Stebbing, J., & Giamas, G. (2013). SILAC-based phosphoproteomics reveals an inhibitory role of KSR1 in p53 transcriptional activity via modulation of DBC1. British Journal of Cancer, 109(10), 2675-2684. doi:10.1038/bjc.2013.628
Article. View on figshare. - Lit, L. C., Scott, S., Zhang, H., Stebbing, J., Photiou, A., & Giamas, G. (2013). LATS2 is a modulator of estrogen receptor alpha. Anticancer Research, 33(1), 53-63.
Article. View on figshare.
2012
- Giamas, G., Xu, Y., Filipovic, A., Grothey, A., Coombes, C. R., & Stebbing, J. (2012). Abstract P6-04-15: The involvement of LMTK3 in endocrine resistance is mediated via multiple signaling pathways. In Cancer Research Vol. 72. American Association for Cancer Research (AACR). doi:10.1158/0008-5472.sabcs12-p6-04-15
Conference publication. View online. - Zhang, H., Lombardo, Y., Filipovic, A., Periyasamy, M., Coombes, R. C., Stebbing, J., & Giamas, G. (2012). Abstract P1-04-04: KSR1 is involved in functional interaction between p53 and BRCA1 and is an independent predictor of overall survival in breast cancer. In Cancer Research Vol. 72. American Association for Cancer Research (AACR). doi:10.1158/0008-5472.sabcs12-p1-04-04
Conference publication. View online. - Lombardo, Y., Filipovic, A., Molyneux, G., Periyasamy, M., Giamas, G., Hu, Y., . . . Coombes, R. C. (2012). Nicastrin regulates breast cancer stem cell properties and tumor growth in vitro and in vivo. Proceedings of the National Academy of Sciences, 109(41), 16558-16563. doi:10.1073/pnas.1206268109
Article. View on figshare. - Xu, Y., & Giamas, G. (2012). [Editorial] Breast cancer and LMTK3: old disease, new target. Breast Cancer Management, 1(2), 101-103. doi:10.2217/bmt.12.23
Article. View on figshare. - Schirripa, M., Loupakis, F., Cremolini, C., Dongyun, Y., Labonte, M. J., Zhang, W., . . . Lenz, H. J. (2012). PD-0016 KSR1 gene polymorphism in mcrc patients treated with first-line folfiri and bevacizumab. Annals of Oncology, 23, iv24. doi:10.1016/s0923-7534(19)66510-5
Article. View on figshare. - Zhang, H., Photiou, A., Grothey, A., Stebbing, J., & Giamas, G. (2012). The role of pseudokinases in cancer. Cellular Signalling, 24(6), 1173-1184. doi:10.1016/j.cellsig.2012.01.017
Article. View on figshare. - Zhang, W., Benhaim, L., Yang, D., Gerger, A., Bohanes, P. O., Páez, D., . . . Lenz, H. -J. (2012). Genetic variants of kinases suppressors of ras (KSR1) to predict survival in patients with ER-alpha positive metastatic breast cancer.. Journal of Clinical Oncology, 30(15_suppl), e11018. doi:10.1200/jco.2012.30.15_suppl.e11018
Article. View online. - Barzi, A., Wakatsuki, T., Zhang, W., Yang, D., Loupakis, F., Ning, Y., . . . Lenz, H. -J. (2012). Prognostic value of lemur tyrosine kinase-3 (LMTK3) polymorphism in Japanese (J) patients (PTS) with localized gastric adenocarcinoma (GAC).. Journal of Clinical Oncology, 30(15_suppl), 4088. doi:10.1200/jco.2012.30.15_suppl.4088
Article. View online. - Benhaim, L., Loupakis, F., Zhang, W., Gerger, A., Bohanes, P. O., Páez, D., . . . Lenz, H. -J. (2012). Genetic variants of kinases suppressors of ras in KRAS-BRAF wild-type metastatic colorectal cancer patients treated with cetuximab and irinotecan. Journal of Clinical Oncology, 30(15), 3597. doi:10.1200/jco.2012.30.15_suppl.3597
Article. View on figshare. - Schirripa, M., Loupakis, F., Cremolini, C., Yang, D., Labonte, M. J., Zhang, W., . . . Lenz, H. -J. (2012). KSR1 gene polymorphism in mCRC patients treated with first-line FOLFIRI and bevacizumab. Journal of Clinical Oncology, 30(15), 3546. doi:10.1200/jco.2012.30.15_suppl.3546
Article. View on figshare. - Barzi, A., Wakatsuki, T., Zhang, W., Yang, D., Loupakis, F., Ning, Y., . . . Lenz, H. -J. (2012). Prognostic value of lemur tyrosine kinase-3 (LMTK3) polymorphism in Japanese (J) patients (PTS) with localized gastric adenocarcinoma (GAC). In Journal of Clinical Oncology Vol. 30 (pp. 4088). Chicago, Illinois: American Society of Clinical Oncology (ASCO). doi:10.1200/jco.2012.30.15_suppl.4088
Conference publication. View on figshare. - Zhang, W., Benhaim, L., Yang, D., Gerger, A., Bohanes, P. O., Páez, D., . . . Lenz, H. -J. (2012). Genetic variants of kinases suppressors of ras (KSR1) to predict survival in patients with ER-alpha positive metastatic breast cancer. In Journal of Clinical Oncology Vol. 30 (pp. e11018 ( pages)). Chicago, Illinois: American Society of Clinical Oncology (ASCO). doi:10.1200/jco.2012.30.15_suppl.e11018
Conference publication. View on figshare. - Giamas, G., Zhang, H., Zhang, W., Filipovic, A., Lenz, H. -J., & Stebbing, J. (2012). Abstract 64: Identification of novel kinases involved in Estrogen receptor-α (ERα) signalling and the development of endocrine resistance in breast cancer. In Cancer Research Vol. 72 (pp. 64). American Association for Cancer Research (AACR). doi:10.1158/1538-7445.am2012-64
Conference publication. View online. - Zhang, H. X. J., Paez, D., Giamas, G., Filipovic, A., Yang, D., Bohanes, P., . . . Lenz, H. -J. (2012). Abstract 2670: Genetic variants in human epidermal growth factor receptor (HER) family gene predict tumor recurrence in breast cancer. In Cancer Research Vol. 72 (pp. 2670). American Association for Cancer Research (AACR). doi:10.1158/1538-7445.am2012-2670
Conference publication. View online. - Stebbing, J., Filipovic, A., Ellis, I. O., Green, A. R., D'Silva, T. R., Lenz, H. -J., . . . Giamas, G. (2012). LMTK3 expression in breast cancer: association with tumor phenotype and clinical outcome. Breast Cancer Research and Treatment, 132(2), 537-544. doi:10.1007/s10549-011-1622-z
Article. View on figshare. - Jiao, L. R., Frampton, A. E., Jacob, J., Pellegrino, L., Krell, J., Giamas, G., . . . Castellano, L. (2012). MicroRNAs targeting oncogenes are down-regulated in pancreatic malignant transformation from benign tumors. PLoS ONE, 7(2), pages. doi:10.1371/journal.pone.0032068
Article. View on figshare. - Zhang, W., Gerger, A., Labonte, M. J., Yang, D., Bohanes, P. O., Ning, Y., . . . Lenz, H. -J. (2012). Association of gender-related tumor recurrence with a polymorphic variant of LMTK3 in stage II and III colon cancer. In Journal of Clinical Oncology Vol. 30 (pp. 454). American Society of Clinical Oncology. doi:10.1200/jco.2012.30.4_suppl.454
Conference publication. View on figshare. - Wakatsuki, T., Bohanes, P. O., Zhang, W., Gerger, A., Yang, D., Ning, Y., . . . Lenz, H. -J. (2012). Use of genetic variants of LMTK3 to predict tumor recurrence in female localized gastric adenocarcinoma. In Journal of Clinical Oncology Vol. 30 (pp. 63). San Francisco, California: American Society of Clinical Oncology. doi:10.1200/jco.2012.30.4_suppl.63
Conference publication. View on figshare. - Loupakis, F., Zhang, W., Gerger, A., Yang, D., Bohanes, P. O., Labonte, M. J., . . . Lenz, H. -J. (2012). LMTK3 polymorphism in patients with metastatic colon cancer.. In JOURNAL OF CLINICAL ONCOLOGY Vol. 30. doi:10.1200/jco.2012.30.4_suppl.471
Conference publication. View online.
2011
- Filipovic, A., Giamas, G., & Stebbing, J. (2011). The potential role of cyclooxygenase-2 (COX-2) during early breast cancer therapy. Annals of Oncology, 22(8), 1700-1702. doi:10.1093/annonc/mdr266
Article. View on figshare. - Giamas, G. (2011). LMTK3: a novel therapeutic target for breast cancer. Pharmacogenomics, 12(7), 931-932. doi:10.2217/pgs.11.78
Article. View on figshare. - Stebbing, J., Filipovic, A., & Giamas, G. (2011). Lemur tyrosine kinase-3 (LMTK3) in cancer and evolution. Oncotarget, 2(6), 428-9.
Article. View on figshare. - Stebbing, J., Filipovic, A., & Giamas, G. (2011). [Editorial] LMTK3 and evolution. Oncotarget, 2, 428-429. doi:10.18632/oncotarget.v2i6
Article. View on figshare. - Giamas, G., Filipovic, A., Jacob, J., Messier, W., Zhang, H., Yang, D., . . . Stebbing, J. (n.d.). Kinome screening for regulators of the estrogen receptor identifies LMTK3 as a new therapeutic target in breast cancer. Nature Medicine, 17(6), 715-719. doi:10.1038/nm.2351
Article. View on figshare. - Winder, T., Giamas, G., Zhang, W., Yang, D., Bohanes, P. O., Ning, Y., . . . Lenz, H. (2011). Use of insulin-like growth factor (IGF) pathway polymorphism IGF1R_rs2016347 to predict tumor recurrence in estrogen receptor-positive breast cancer patients. In Journal of Clinical Oncology Vol. 29 (pp. 538). Chicago, Illinois: American Society of Clinical Oncology. doi:10.1200/jco.2011.29.15_suppl.538
Conference publication. View on figshare.
2010
- Giamas, G., Filipovic, A., Jacob, J., Shifa, B. A., Green, A. R., Ellis, I. O., . . . Stebbing, J. (2010). Abstract S3-7: Kinome Screening for Regulators of Estrogen Receptor Identifies a Novel Kinase as a New Therapeutic Target in Breast Cancer. In Cancer Research Vol. 70. American Association for Cancer Research (AACR). doi:10.1158/0008-5472.sabcs10-s3-7
Conference publication. View online. - Man, Y. L., Filipovic, A., Stebbing, J., & Giamas, G. (2010). New and established targets for the treatment of breast cancer. Advances in Breast Cancer, 7(3), 10-13.
Article. View on figshare. - Filipovic, A., Giamas, G., Coombes, R. C., & Stebbing, J. (2010). Gamma secretase and Notch as therapeutic targets in cancer. Advances in Breast Cancer, 7(3), 2-5.
Article. View on figshare. - Giamas, G., Man, Y. L., Hirner, H., Bischof, J., Kramer, K., Khan, K., . . . Knippschild, U. (2010). Kinases as targets in the treatment of solid tumors. Cellular Signalling, 22(7), 984-1002. doi:10.1016/j.cellsig.2010.01.011
Article. View on figshare. - Giamas, G., Filipovic, A., Jacob, J., & Stebbing, J. (2010). Abstract LB-226: Identification of novel kinases modulating ER: new therapeutic targets in breast cancer. In Cancer Research Vol. 70. American Association for Cancer Research (AACR). doi:10.1158/1538-7445.am10-lb-226
Conference publication. View online.
2009
- Castellano, L., Giamas, G., Jacob, J., Coombes, R. C., Lucchesi, W., Thiruchelvam, P., . . . Stebbing, J. (2009). The estrogen receptor-alpha-induced microRNA signature regulates itself and its transcriptional response. Proceedings of the National Academy of Sciences, 106(37), 15732-15737. doi:10.1073/pnas.0906947106
Article. View on figshare. - Giamas, G., Castellano, L., Feng, Q., Knippschild, U., Jacob, J., Thomas, R. S., . . . Stebbing, J. (2009). CK1d modulates the transcriptional activity of ERa via AIB1 in an estrogen-dependent manner and regulates ERa-AIB1 interactions. Nucleic Acids Research, 37(9), 3110-3123. doi:10.1093/nar/gkp136
Article. View on figshare.
2008
- Mintz, P. J., Habib, N. A., Jones, L. J., Giamas, G., Lewis, J. S., Bowen, R. L., . . . Stebbing, J. (2008). The phosphorylated membrane estrogen receptor and cytoplasmic signaling and apoptosis proteins in human breast cancer. Cancer, 113(6), 1489-1495. doi:10.1002/cncr.23699
Article. View on figshare. - Castellano, L., Waxman, J., Giamas, G., Apostolopous, C., & Stebbing, J. (2008). The identification of new tumour suppressor micromas epigenetically silenced in drug resistant cancer cells. In European Journal of Cancer Supplements Vol. 6 (pp. 95). Lyon, France: Elsevier. doi:10.1016/S1359-6349(08)71541-6
Conference publication. View on figshare. - Apostolopoulos, C., Castellano, L., Stebbing, J., & Giamas, G. (n.d.). Bendamustine as a model for the activity of alkylating agents. Future Oncology, 4(3), 323-332. doi:10.2217/14796694.4.3.323
Article. View on figshare. - Brockschmidt, C., Hirner, H., Huber, N., Eismann, T., Hillenbrand, A., Giamas, G., . . . Knippschild, U. (2008). Anti-apoptotic and growth-stimulatory functions of CK1 delta and epsilon in ductal adenocarcinoma of the pancreas are inhibited by IC261 in vitro and in vivo. Gut, 57(6), 799-806. doi:10.1136/gut.2007.123695
Article. View on figshare. - Giamas, G., Ali, S., Apostolopoulos, C., Castellano, L., Coombes, C., & Stebbing, J. (2008). The identification of new signaling pathways involved in estrogen receptor-alpha (ER alpha) transcriptional activity. In FEBS JOURNAL Vol. 275 (pp. 137). Athens, Greece.
Conference publication. View on figshare. - Castellano, L., Waxman, J., Giamas, G., Apostolopoulous, C., & Stebbing, J. (2008). The identification of new tumour suppressor microRNAs epigenetically silenced in drug resistant cancer cells. In FEBS JOURNAL Vol. 275 (pp. 152). Retrieved from https://www.webofscience.com/
Conference publication.
2007
- von Blume, J., Knippschild, U., Dequiedt, F., Giamas, G., Beck, A., Auer, A., . . . Seufferlein, T. (2007). Phosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2. EMBO Journal, 26(22), 4619-4633. doi:10.1038/sj.emboj.7601891
Article. View on figshare. - Apostolopoulos, C., Giamas, G., & Stebbing, J. (2007). Clinical significance of circulating tumor cells. Biomarkers in Medicine, 1(3), 341-342. doi:10.2217/17520363.1.3.341
Article. View on figshare. - Giamas, G., Hirner, H., Shoshiashvili, L., Grothey, A., Gessert, S., Kühl, M., . . . Knippschild, U. (2007). Phosphorylation of CK1d: identification of Ser370 as the major phosphorylation site targeted by PKA in vitro and in vivo. Biochemical Journal, 406(3), 389-398. doi:10.1042/BJ20070091
Article. View on figshare. - Giamas, G., Stebbing, J., Vorgias, C. E., & Knippschild, U. (2007). Protein kinases as targets for cancer treatment. Pharmacogenomics, 8(8), 1005-1016. doi:10.2217/14622416.8.8.1005
Article. View on figshare.
2006
- Wolff, S., Stöter, M., Giamas, G., Piesche, M., Henne-Bruns, D., Banting, G., & Knippschild, U. (2006). Casein kinase 1 delta (CK1delta) interacts with the SNARE associated protein snapin. FEBS Letters, 580(27), 6477-6484. doi:10.1016/j.febslet.2006.10.068
Article. View on figshare. - Knippschild, U., Shoshiashvili, L., Henne-Bruns, D., & Giamas, G. (2006). Regulation der Casein Kinase 1 delta (CK1δ) Aktivität durch Protein Kinase A (PKA): ein Ansatzpunkt für neue Therapiekonzepte in der Tumorbehandlung?. In Chirurgisches Forum 2006 (pp. 143-144). Springer Berlin Heidelberg. doi:10.1007/3-540-34668-6_47
Chapter. View online. - Brockschmidt, C., Eismann, T., Kalthoff, H., Henne-Bruns, D., Trauzold, A., Bohm, B., . . . Knippschild, U. (2006). Sensibilisierung resistenter Pankreastumorzelllinien gegenüber einer CD95 vermittelten Apoptose durch Casein Kinase 1 (CK1) spezifische Inhibitoren. In Chirurgisches Forum 2006 (pp. 145-146). Springer Berlin Heidelberg. doi:10.1007/3-540-34668-6_48
Chapter. View online.
2005
- Knippschild, U., Wolff, S., Giamas, G., Brockschmidt, C., Wittau, M., Würl, P. U., . . . Stöter, M. (2005). The role of the casein kinase 1 (CK1) family in different signaling pathways linked to cancer development. Onkologie, 28(10), 508-514. doi:10.1159/000087137
Article. View on figshare.
Unpublished works
- Gagliano, T., Ditsiou, A., Grothey, A., & Giamas, G. (n.d.). Human kinome siRNA screening to identify novel targets implicated in fibroblast-mediated triple negative breast cancer cells invasion. Poster session presented at the meeting of EACR conference series goodbye flat biology: models, mechanisms and microenvironment.
Poster. View on figshare. - Knippschild, U., Shoshiashvili, L., Henne-Bruns, D., & Giamas, G. (n.d.). Einfluss zellulärer Kinasen auf die Aktivität von CK1δ in pankreatischen Tumorzelllinien. In Chirurgisches Forum 2007 (pp. 105-106). Springer Berlin Heidelberg. doi:10.1007/978-3-540-71123-0_33
Chapter. View online.