SLORTH

http://slorth.biochem.sussex.ac.uk/

Slorth is a database of synthetic lethal interaction that are either experimentally verified or are high quality predictions using the state of the art algorithm SLant. SLant works by using synthetic lethal data from human, worm, fly and yeast sources to identify the patterns in the protein-protein interaction network associated with being part of a synthetic lethal interaction. By searching the human network for protein pairs that match these patterns, it can effectively predict new synthetic lethal pairs. 

MOKCA

http://strubiol.icr.ac.uk/extra/mokca/

The MOKCa database (Mutations, Oncogenes, Knowledge & Cancer) has been developed to structurally and functionally annotate, and where possible predict, the phenotypic consequences of mutations implicated in cancer.

It is an update of the original MoKCa database that focused on kinases. It has been updated and expanded to include other groups of proteins implicated in carcinogenesis. This includes documented oncogenes (CGC oncogenes) and tumour supressors (CGC Tumour supressor).

MEXDRUGS

MexDrugs is a database of genetic interactions that were found to be mutually exclusive in multi-'omic data from The Cancer Genome Atlas using the algorithm MexD.

MexD uses matched somatic mutation, copy number variance and methylation data from The Cancer Genome Atlas, together with drug information from the Druggable genome databank, to identify cancer-associated genes that are mutually exclusive with genes that are inhibited by existing drugs.In some cases these genetic interactions may arise because the genes are synthetically lethal.

I also used to run the CATH database, when I was a member of the Orengo group.

CATH is a classification of protein structures downloaded from the Protein Data Bank. We group protein domains into superfamilies when there is sufficient evidence they have diverged from a common ancestor.Gene3D uses the information in CATH to predict the locations of structural domains on millions of protein sequences available in public databases. This allows us to include additional annotations to the CATH-Gene3D database such as functional information and active site residues.