Introduction

The Murray lab focuses on the mechanisms of replication restart, how replication and recombination are coordinated and the consequences of mis-regulation for genome instability and cancer. We use a combination of genome-wide and site-specific approaches, in fission yeast and human cell lines, to study the coordination of replication with recombination. We focus on the roles of recombination regulators such as the Smc5/6 complex in replication fork stability. This is essential complex is required for the regulation of recombination and accurate chromosome segregation.  

Our research work is funded by: