Publications & patents

Ottolini, C., Newnham, L., Capalbo, A., Natesan, S. A., Joshi, H.A., Cimadomo, D., Griffin, D.K., Sage, K., Summers, M.C., Thornhill, A.R., Housworth E., Herbert, A.D., Rienzi, L., Ubaldi, F., Handyside, A.H., and Hoffmann, E.R. (2015) “MeioMaps of genome-wide recombination and chromosome segregation in human oocytes and embryos reveal selection for maternal recombination rates”. Nature Genetics (accepted).

Irene Gallina, Camilla Colding, Peter Henriksen, Petra Beli, Kyosuke Nakamura, Judith Offman, David P. Mathiasen, Sonia Silva, Eva Hoffmann, Anja Groth, Chunaram Choudhary, and Michael Lisby (2015). “Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control”. Nature Communications (in press).

Herbert, A.D., Carr, A.M, and Hoffmann, E. (2014). FindFoci: An foci detection algorithm with automated parameter training that closely matches human assignments, reduces human inconsistencies and increases speed of analysis. PLoS One 9:e114749.

Copsey, A., Tang, S., Jordan, P.W., Blitzblau, H.G., Newcombe, S., Chan, A.C., Newnham, L., Li, Z., Gray, S., Herbert, A.D., et al. (2013). Smc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic divisions. PLoS Genet 9: e1004071.

Newcombe, S., Bobin, M., Shrikhande, A., Gallop, C., Pace, Y., Yong, H., Gates, R., Chaudhuri, S., Roe, M., Hoffmann, E., et al. (2013). Gold amides as anticancer drugs: synthesis and activity studies. Org Biomol Chem 11: 3255-3260.

Newnham, L., Jordan, P.W., Carballo, J.A., Newcombe, S., and Hoffmann, E. (2013). Ipl1/Aurora kinase suppresses S-CDK-driven spindle formation during prophase I to ensure chromosome integrity during meiosis. PLoS One 8: e83982.

Sarkar, S., Shenoy, R.T., Dalgaard, J.Z., Newnham, L., Hoffmann, E., Millar, J.B., and Arumugam, P. (2013). Monopolin subunit Csm1 associates with MIND complex to establish monopolar attachment of sister kinetochores at meiosis I. PLoS Genet 9: e1003610.

Gatz, S.A., Ju, L., Gruber, R., Hoffmann, E., Carr, A.M., Wang, Z.Q., Liu, C., and Jeggo, P.A. (2011). Requirement for DNA ligase IV during embryonic neuronal development. J Neurosci 31: 10088-10100.

Hoffmann, E. (2011). Chromosome recombination. Semin Cell Dev Biol 22: 865.

Watts, F.Z., and Hoffmann, E. (2011). SUMO meets meiosis: an encounter at the synaptonemal complex: SUMO chains and sumoylated proteins suggest that heterogeneous and complex interactions lie at the centre of the synaptonemal complex. Bioessays 33: 529-537.

Cotton, V.E., Hoffmann, E.R., and Borts, R.H. (2010). Distinct regulation of Mlh1p heterodimers in meiosis and mitosis in Saccharomyces cerevisiae. Genetics 185: 459-467.

Falk, J.E., Chan, A.C., Hoffmann, E., and Hochwagen, A. (2010). A Mec1- and PP4-dependent checkpoint couples centromere pairing to meiotic recombination. Dev Cell 19: 599-611.

Newnham, L., Jordan, P., Rockmill, B., Roeder, G.S., and Hoffmann, E. (2010). The synaptonemal complex protein, Zip1, promotes the segregation of nonexchange chromosomes at meiosis I. Proc Natl Acad Sci U S A 107: 781-785.

Chan, A.C., Borts, R.H., and Hoffmann, E. (2009). Temperature-dependent modulation of chromosome segregation in msh4 mutants of budding yeast. PLoS One 4: e7284.

Clyne, M., Offman, J., Shanley, S., Virgo, J.D., Radulovic, M., Wang, Y., Ardern-Jones, A., Eeles, R., Hoffmann, E., and Yu, V.P. (2009). The G67E mutation in hMLH1 is associated with an unusual presentation of Lynch syndrome. Br J Cancer 100: 376-380.

Cotton, V.E., Hoffmann, E.R., Abdullah, M.F., and Borts, R.H. (2009). Interaction of genetic and environmental factors in Saccharomyces cerevisiae meiosis: the devil is in the details. Methods Mol Biol 557: 3-20.

Jordan, P., Copsey, A., Newnham, L., Kolar, E., Lichten, M., and Hoffmann, E. (2009). Ipl1/Aurora B kinase coordinates synaptonemal complex disassembly with cell cycle progression and crossover formation in budding yeast meiosis. Genes Dev 23: 2237-2251.

Hoffmann, E.R., Eriksson, E., Herbert, B.J., and Borts, R.H. (2005). MLH1 and MSH2 promote the symmetry of double-strand break repair events at the HIS4 hotspot in Saccharomyces cerevisiae. Genetics 169: 1291-1303.

Hoffmann, E.R., and Borts, R.H. (2005). Trans events associated with crossovers are revealed in the absence of mismatch repair genes in Saccharomyces cerevisiae. Genetics 169: 1305-1310.

Abdullah, M.F., Hoffmann, E.R., Cotton, V.E., and Borts, R.H. (2004). A role for the MutL homologue MLH2 in controlling heteroduplex formation and in regulating between two different crossover pathways in budding yeast. Cytogenet Genome Res 107: 180-190.

Hoffmann, E.R., and Borts, R.H. (2004). Meiotic recombination intermediates and mismatch repair proteins. Cytogenet Genome Res 107: 232-248.

Hoffmann, E.R., Shcherbakova, P.V., Kunkel, T.A., and Borts, R.H. (2003). MLH1 mutations differentially affect meiotic functions in Saccharomyces cerevisiae. Genetics 163: 515-526.

Hjorth-Sorensen, B., Hoffmann, E.R., Lissin, N.M., Sewell, A.K., and Jakobsen, B.K. (2001). Activation of heat shock transcription factor in yeast is not influenced by the levels of expression of heat shock proteins. Mol Microbiol 39: 914-923.